Results 21 to 30 of about 6,635 (208)

Extremely Complex Repeat Shuffling during Germline Mutation at Human Minisatellite B6.7 [PDF]

Human Molecular Genetics, 1999
Human minisatellite B6.7 is a highly variable locus showing extensive heterozygosity with alleles ranging from six to >500 repeat units. Paternal and maternal mutation rates to new length alleles were estimated from pedigrees at 7.0 and 3.9% per gamete, respectively, indicating that B6.7 is one of the most unstable minisatellites isolated to date ...
Keiji Tamaki, Celia A. May, Yuri E. Dubrova, A. J. Jeffreys   +3 more
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Comparative Sequence Analysis of Human Minisatellites Showing Meiotic Repeat Instability [PDF]

Genome Research, 1999
The highly variable human minisatellites MS32 (D1S8), MS31A (D7S21), and CEB1 (D2S90) all show recombination-based repeat instability restricted to the germline. Mutation usually results in polar interallelic conversion or occasionally in crossovers, which, at MS32 at least, extend into DNA flanking the repeat array, defining a localized recombination ...
John M. Murray, Jérôme Buard, David L. Neil, Edouard Yeramian, Keiji Tamaki, Caroline R. H. Hollies, Alec J. Jeffreys   +6 more
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Slipped-Strand Mispairing at Noncontiguous Repeats in Poecilia reticulata: A Model for Minisatellite Birth [PDF]

Genetics, 2000
Abstract The standard slipped-strand mispairing (SSM) model for the formation of variable number tandem repeats (VNTRs) proposes that a few tandem repeats, produced by chance mutations, provide the “raw material” for VNTR expansion. However, this model is unlikely to explain the formation of VNTRs with long motifs (e.g., minisatellites),
John S. Taylor, Felix Breden
openalex   +3 more sources

M13 repeat probe detects DNA minisatellite-like sequences in gymnosperms and angiosperms. [PDF]

Proceedings of the National Academy of Sciences, 1988
Several kinds of minisatellite DNA, all of which are composed of low to moderately repetitive DNA, have been identified in tetrapod genomes. While the repeating oligonucleotide elements (subrepeats) of a given minisatellite are virtually identical, subrepeat nucleotide composition differs between different minisatellites.
Steven H. Rogstad, John C. Patton, Barbara A. Schaal   +2 more
openalex   +4 more sources

Minisatellite variant repeat (MVR) mapping: analysis of ‘null’ repeat units at D1S8 [PDF]

Human Molecular Genetics, 1992
Minisatellite variant repeat mapping by PCR (MVR-PCR) is a new approach to studying variation in human DNA which analyses interspersion patterns of variant repeats within minisatellite arrays. MVR-PCR has been applied to the hypervariable human minisatellite D1S8 which contains two major classes of variant 29bp repeat units designated a-type and t-type.
K, Tamaki, D G, Monckton, A, MacLeod, D L, Neil, M, Allen, A J, Jeffreys   +5 more
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Erratum to Evidence for Multiple Origins of Human Infectivity in Trypanosoma brucei Revealed by Minisatellite Variant Repeat Mapping [PDF]

Journal of Molecular Evolution, 2002
In recent years a wide variety of biochemical and molecular typing systems has been employed in the study of parasite diversity aimed at investigating the level of genetic diversity and delineating the relationship between different species and subspecies.
Annette MacLeod, Susan C. Welburn, Ian Maudlin, C. Michael R. Turner, Andy Tait   +4 more
openalex   +3 more sources

MNS16A tandem repeats minisatellite of human telomerase gene: a risk factor for colorectal cancer [PDF]

Carcinogenesis, 2011
Telomerase reactivation and expression of human telomerase gene [human telomerase reverse transcriptase (hTERT)] are hallmarks of unlimited proliferation potential of cancer cells. A polymorphic tandem repeats minisatellite of hTERT gene, termed MNS16A was reported to influence hTERT expression.
Philipp Hofer, Andreas Baierl, Elisabeth Feik, Gerhard Führlinger, Gernot Leeb, Karl Mach, Klaus Holzmann, M. Micksche, Andrea Gsur   +8 more
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Simple sequence repeats and their expansions: role in plant development, environmental response and adaptation. [PDF]

New Phytol
Summary Repetitive DNA is a feature of all organisms, ranging from archaea and plants to humans. DNA repeats can be seen both in coding and in noncoding regions of the genome. Due to the recurring nature of the sequences, simple DNA repeats tend to be more prone to errors during replication and repair, resulting in variability in their unit length ...
Sureshkumar S, Chhabra A, Guo YL, Balasubramanian S.   +3 more
europepmc   +2 more sources

Structural characterization of supercoiled DNA containing a minisatellite repeat that has polypurine/polypyrimidine stretch [PDF]

Nucleic Acids Symposium Series, 2007
The pUC19 derivative pAL79 contains six tandem repeats of a 30-bp unit sequence. Supercoiled pAL79 molecules show aberrant electrophoretic mobility under acidic conditions, and microscopic analysis suggests pAL79 molecules conform to tight plectonemes when deposited on a substrate under acidic conditions.
Mikio Kato, Takeshi Haku, Takahiro Yamauchi, Shigeru Sugiyama, Kuniaki Nagayama, Nobutaka Shimizu   +5 more
openalex   +3 more sources

A novel minisatellite repeat expansion identified at FRA16B in a Japanese carrier.

Genes & Genetic Systems, 2000
Previously, the allelic expansion of a 33-bp AT-rich minisatellite repeat has been reported to cause FRA16B, a distamycin A-inducible fragile site. Here, we identified a novel 35-bp minisatellite repeat at FRA16B in a Japanese carrier. The nucleotide sequence of the 35-bp minisatellite was highly AT-rich and nearly identical to the 33-bp one but with ...
Masatake Yamauchi, Satsuki Tsuji, Kazuei Mita, Toshiyuki Saito, Mitsuoki Morimyo   +4 more
openalex   +4 more sources