Results 101 to 110 of about 44,254 (226)

Computational modeling and confirmation of leukemia-associated minor histocompatibility antigens. [PDF]

Blood Adv, 2018
Lansford JL, Dharmasiri U, Chai S, Hunsucker SA, Bortone DS, Keating JE, Schlup IM, Glish GL, Collins EJ, Alatrash G, Molldrem JJ, Armistead PM, Vincent BG.   +12 more
europepmc   +1 more source

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

Advanced Science, Volume 13, Issue 17, 23 March 2026.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao, Xiaoli Cui, Huizhu Du, Zhuoqun Wang, Chang Liu, Linxin Zhang, Jianing Qi, Di Yang, Hui Yu, Shuang Yan, Wei Liu, Haiming Sun, Mengyang Wang   +12 more
wiley   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

CD4 Donor Lymphocyte Infusion Can Cause Conversion of Chimerism Without GVHD by Inducing Immune Responses Targeting Minor Histocompatibility Antigens in HLA Class II. [PDF]

Front Immunol, 2018
van Balen P, van Bergen CAM, van Luxemburg-Heijs SAP, de Klerk W, van Egmond EHM, Veld SAJ, Halkes CJM, Zwaginga JJ, Griffioen M, Jedema I, Falkenburg JHF.   +10 more
europepmc   +1 more source

LILRB1 Is a Prognostic‐Related Biomarker Correlated With Immune Infiltration in Head–Neck Squamous Cell Carcinoma

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background Conventional treatment strategies and immunotherapy yield low response rates in head and neck squamous cell carcinoma (HNSCC). This study aimed to explore the potential of immunosuppressive receptor leukocyte immunoglobulin‐like receptor subfamily B member 1 (LILRB1) for developing effective immunotherapies for HNSCC.
Shuai Chen, Qiuwan Wu, Shuo Gu, Yi Zhou, Mingquan Cai, Junhua Wu, Jing He, Jingjing He, Juli Lin, Zhicong Hong, Binghuang Zhang, Xianyang Luo   +11 more
wiley   +1 more source

Autosomal Minor Histocompatibility Antigens: How Genetic Variants Create Diversity in Immune Targets. [PDF]

Front Immunol, 2016
Griffioen M, van Bergen CA, Falkenburg JH.   +2 more
europepmc   +1 more source

Non‐cognate CD8 Binding to MHC I Promotes Positive Selection of an MHC‐E Restricted CD8 T Cell Population

European Journal of Immunology, Volume 56, Issue 3, March 2026.
Mouse Qa1b‐restricted T cells show promiscuous requirements for positive selection. Using in vivo tetramer enrichment, in vitro APC engineering, and in vitro thymocyte stimulation, we demonstrate that a Qa1b‐restricted T cell population can be selected by both Qa1b and H2‐T11, and depends on non‐cognate CD8‐MHC I binding.
Xiaokun Yang, Melissa A. Colden, Rachel Coombs, Kathya Arana, Dan Tran, Michael Manoharan Valerio, Ellen A. Robey, Laurent Coscoy   +7 more
wiley   +1 more source

High-throughput cloning reveals diverse properties of T-cell receptors targeting minor histocompatibility antigens. [PDF]

Blood Adv
Ito S, Martin E, Panousis C, Rowe AM, Stras S, Roy J, Cofano EB, Ventura K, Parr K, Neupane B, Bellesis A, Toki A, Jing R, Jang J, Neves AT, Shlomchik MJ, Shlomchik WD.   +16 more
europepmc   +1 more source

Identification of minor histocompatibility antigens based on the 1000 Genomes Project. [PDF]

Haematologica, 2014
Oostvogels R, Lokhorst HM, Minnema MC, van Elk M, van den Oudenalder K, Spierings E, Mutis T, Spaapen RM.   +7 more
europepmc   +1 more source

Investigating the Impact of Host Genetics on the Risk of Disease Progression in Individuals With Influenza

Immunity, Inflammation and Disease, Volume 14, Issue 3, March 2026.
We utilized a novel targeted and genome‐wide association study (GWAS) approach, whereby SNPs with prior evidence in other viral upper respiratory tract infections were assessed in a targeted approach and all other SNPs in a GWAS approach. The probability of making a Type 1 error (i.e., the “alpha”) was split between the targeted analysis and the GWAS ...
Sara Bohnstedt Mørup, Maja Milojevic, Seyed Mahmood Taghavi Shahri, Brad T. Sherman, Weizhong Chang, Ruth Lynfield, Marie Helleberg, Melissa Skeans, Lars Østergaard, Line Borgwardt, Norman Gerry, Marcelo Losso, Kenneth Baillie, Richard Davey, Dominic E. Dwyer, Chansavath Phetsouphanh, Vasileios Papastamopoulos, Richard M. Novak, Daniel D. Murray, Joanne Reekie, Jens D. Lundgren, H. Clifford Lane, Cavan Reilly, For the INSIGHT FLU 002 Plus and FLU 003 Plus Study Groups   +23 more
wiley   +1 more source