Results 121 to 130 of about 23,170 (228)

Antibody Responses to Minor Histocompatibility Antigens After Solid Organ Transplantation. [PDF]

Transplantation, 2022
Zorn E, See SB.
europepmc   +1 more source

Diagnostic utility of inflammatory markers in formalin‐fixed and paraffin‐embedded muscle biopsies for idiopathic inflammatory myopathies

Histopathology, EarlyView.
Formalin‐fixed, paraffin‐embedded (FFPE) muscle tissue supports robust immunohistochemical detection of MHC II, MxA, and p62 with performance comparable to frozen sections. This approach reliably identifies the pathological signatures of inclusion body myositis, dermatomyositis, immune‐mediated necrotizing myopathy, and overlap myositis, enhancing the ...
Chinnawut Suriyonplengsaeng, Jariya Waisayarat   +1 more
wiley   +1 more source

Identification of MHC II-restricted minor histocompatibility antigens after HLA-identical stem-cell transplantation. [PDF]

, 2010
BACKGROUND: After allogeneic hematopoietic stem-cell transplantation (HSCT), donor-derived T cells may elicit graft-versus-host disease (GVHD) and graft-versus-tumor (GVT) responses.
Witter, K., Karim, K., Bachnick, B., Behrends, U., Gerbitz, A., Bornkamm, G.W., Mautner, J., Milosevic, S.   +7 more
core   +1 more source

Inducing Antigen‐Specific and Functional Immune Responses in Mice Toward Bovine Herpesvirus 1 and Bovine Respiratory Syncytial Virus by Chimeric Peptides Delivered by Bovine Herpesvirus 4‐Based Vector

Immunology, EarlyView.
Bovine Alphaherpesvirus 1 (BoHV‐1) and Bovine respiratory syncytial virus (BRSV) are major drivers of respiratory disease in cattle. (A) To target both pathogens, two chimeric antigens—membrane‐linked and secreted—combining BoHV‐1 glycoprotein D and BRSV fusion glycoprotein were designed and expressed using recombinant BoHV‐4‐based vectors.
Antonino Di Lorenzo, Sergio Minesso, Chiara Cossu, Valentina Franceschi, Elisabetta Bolli, Vittorio Madia, Laura Conti, Gaetano Donofrio   +7 more
wiley   +1 more source

Current developments in T-cell receptor therapy for acute myeloid leukemia

Blood Advances
: T-cell receptor (TCR) therapies are a promising modality for the treatment of cancers, with significant efforts being directed toward acute myeloid leukemia (AML), a particularly challenging disease.
Sayali Gore, Emily Blyth, Marie Bleakley, Koon Lee, Kenneth Micklethwaite, Kavitha Gowrishankar   +5 more
doaj   +1 more source

Gamma-delta T cells in glioblastoma immunotherapy

Glioma, 2019
Conventional immunotherapy in the treatment of glioblastoma (GBM) has essentially produced no significant advantage over the use of chemotherapeutic drugs.
Sadhak Sengupta
doaj   +1 more source

Mapping malignant T‐cell states and immune circuits in Sézary syndrome by single‐cell analysis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Peripheral blood single‐cell RNA‐seq from leukaemic CTCL defined three malignant T‐cell programmes: MTC CM, MTC Reg and MTC E/EM, each with distinct features and candidate vulnerabilities. For example, inferred immune circuits highlighted actionable IL‐10/JAK–TYK2–STAT3 signalling, KIR–MHC I inhibitory interactions and myeloid/B‐cell inflammatory and ...
Beth A. Childs, Eslam A. Elghonaimy, Praveen Ramakrishnan Geethakumari, Kiran A. Kumar, Joseph F. Merola, Heather W. Goff, Todd A. Aguilera   +6 more
wiley   +1 more source

Use of monoclonal antibodies to study alloreactivity and T cell development in Xenopus [PDF]

, 1993
This study investigated T-cell surface antigenic changes in the spleen of Xenopus following in vivo and in vitro allergenic challenge, using novel mouse monoclonal antibodies (mAb's) against all T cells (CDS), the putative ɑβ-T cell receptor (TCR), the ...
Paul, Tina
core  

Allorecognition Unveiled: Integrating Recent Breakthroughs Into the Current Paradigm

Transplant International
In transplantation, genetic differences between donor and recipient trigger immune responses that cause graft rejection. Allorecognition, the process by which the immune system discriminates allogeneic grafts, targets major histocompatibility complex ...
Xavier Charmetant, Xavier Charmetant, Xavier Charmetant, Gavin J. Pettigrew, Olivier Thaunat, Olivier Thaunat, Olivier Thaunat   +6 more
doaj   +1 more source

Lagochilascaris minor: Susceptibility and Resistance to Experimental Infection in Mice Is Independent of H-2a Haplotype and Correlates with the Immune Response in Immunized Animals

Journal of Parasitology Research, 2010
Recently, we demonstrated that C57BL/6 mice are more susceptible to experimental lagochilascariosis than BALB/c mice. To investigate the pattern of infection and the role of the genetic background on susceptibility to infection, we studied experimental ...
Mônica Spadafora-Ferreira, Luciana Caetano Fernandes, Irmtraut Araci Hoffman Pfrimer, Cássia Regina Pichiteli, Denise Vilarinho Tambourgi, Ruy de Souza Lino-Junior, Mara Silvia Carvalhaes   +6 more
doaj   +1 more source