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Human minor histocompatibility antigens

Current Opinion in Immunology, 1996
Disparities in minor histocompatibility antigens between HLA-matched organ and bone marrow donors and recipients create a potential risk for graft failure and graft-versus-host disease. These conditions necessitate lifelong pharmacological immunosuppression of organ and bone marrow transplant recipients.
Els Goulmy
exaly   +6 more sources

Minors come of age: minor histocompatibility antigens and graft-versus-host disease

Biology of Blood and Marrow Transplantation, 2004
Minor histocompatibility antigens (miHA) are responsible for the occurrence of graft-versus-host disease in the setting of a major histocompatibility complex matched sibling allogeneic stem cell transplantation.
Nelson J Chao, Chao, Nelson J
exaly   +2 more sources

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Tolerance to minor histocompatibility antigens

Immunology Letters, 1988
A neonatal tolerance model employing fully allogeneic lymphoid cells as tolerogen was used in an investigation of tolerance to self and donor minor histocompatibility antigens (miHA). Tolerance was assessed by skin grafting and subsequently by the generation of cytotoxic T lymphocytes. Two strain combinations were investigated. In the first, BALB/c-B10,
L S, Rayfield, L, Brent, K, Samuel
openaire   +2 more sources

Minor histocompatibility antigens

Immunology Letters, 1991
Immune responses against foreign tissue or organs can be directed against alloantigenic differences between donor and host encoded by genes of the major histocompatibility complex (MHC; HLA in man and H-2 in mouse). However, when MHC antigens are matched, as in HLA-identical siblings, or between different mouse strains sharing the same H-2 haplotype ...
openaire   +4 more sources

Minor Histocompatibility Antigens and Marrow Transplantation

New England Journal of Medicine, 1996
Acute graft-versus-host disease (GVHD) and graft rejection are the principal obstacles to successful allogeneic bone marrow transplantation.
N A, Kernan, B, Dupont
openaire   +2 more sources

Major vs minor histocompatibility antigens

Blood, 2017
In this issue of Blood, Martin et al found that the number of minor histocompatibility antigen mismatches doubles in unrelated vs sibling HLA-matched transplants, but has less impact on graft-versus-host disease (GVHD) than mismatching at HLA-DP ...
Denis Claude Roy, Claude Perreault
openaire   +2 more sources

Immunodominant minor histocompatibility antigens: the major ones

Trends in Immunology, 1998
Abstract Minor histocompatibility antigens (MiHAs) are extremely numerous—possibly up to 720 in mice—and have been regarded as an `immunogenetic nightmare' in transplantation. Here, Claude Perreault, Denis Roy and Claudette Fortin summarize evidence showing that most anti-MiHA T-cell responses are oligoclonal, being restricted to several dominant ...
Claude Perreault, Denis C Roy, Claudette Fortin   +2 more
exaly   +3 more sources

Minor histocompatibility antigens – big in tumour therapy

Trends in Immunology, 2004
Technical advances combined with the deciphering of the human genome have facilitated the identification of the molecular nature of human minor histocompatibility (H) antigens. To date, it is believed that minor H antigens result from just any polymorphic protein, regardless of their functional properties.
Spierings, E., Wieles, B., Goulmy, E.A.J.M.   +2 more
openaire   +3 more sources

Molecular Typing Methods for Minor Histocompatibility Antigens

Methods in Molecular Medicine, 2007
Minor histocompatibility (H) antigens crucially affect the outcome of human leukocyte antigen-matched allogeneic stem cell transplantation. The number of molecularly identified minor H antigens is rapidly increasing. In parallel, clinical implementation of minor H antigens for immunotherapy has gained significant interest.
Eric Spierings, Els Goulmy, Spierings Eric   +2 more
exaly   +3 more sources

Presentation and recognition of major and minor histocompatibility antigens

Transplant Immunology, 1994
The structural basis of allorecognition is heterogeneous. For minor histocompatibility antigen-specific T cells and for a minority of anti-MHC T cells (indirect allorecognition), the allogeneic molecule acts as any other protein, and is processed and presented as a peptide in the context of self MHC.
A N, Warrens, G, Lombardi, R I, Lechler
openaire   +2 more sources