Results 211 to 220 of about 861,631 (245)
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Tolerance to minor histocompatibility antigens
Immunology Letters, 1988A neonatal tolerance model employing fully allogeneic lymphoid cells as tolerogen was used in an investigation of tolerance to self and donor minor histocompatibility antigens (miHA). Tolerance was assessed by skin grafting and subsequently by the generation of cytotoxic T lymphocytes. Two strain combinations were investigated. In the first, BALB/c-B10,
L S, Rayfield, L, Brent, K, Samuel
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Minor histocompatibility antigens
Immunology Letters, 1991Immune responses against foreign tissue or organs can be directed against alloantigenic differences between donor and host encoded by genes of the major histocompatibility complex (MHC; HLA in man and H-2 in mouse). However, when MHC antigens are matched, as in HLA-identical siblings, or between different mouse strains sharing the same H-2 haplotype ...
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Major vs minor histocompatibility antigens
Blood, 2017In this issue of Blood, Martin et al found that the number of minor histocompatibility antigen mismatches doubles in unrelated vs sibling HLA-matched transplants, but has less impact on graft-versus-host disease (GVHD) than mismatching at HLA-DP ...
Denis Claude Roy, Claude Perreault
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Minor Histocompatibility Antigens and Marrow Transplantation
New England Journal of Medicine, 1996Acute graft-versus-host disease (GVHD) and graft rejection are the principal obstacles to successful allogeneic bone marrow transplantation.
N A, Kernan, B, Dupont
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Minor histocompatibility antigens – big in tumour therapy
Trends in Immunology, 2004Technical advances combined with the deciphering of the human genome have facilitated the identification of the molecular nature of human minor histocompatibility (H) antigens. To date, it is believed that minor H antigens result from just any polymorphic protein, regardless of their functional properties.
Spierings, E. +2 more
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Immunodominant minor histocompatibility antigens: the major ones
Trends in Immunology, 1998Abstract Minor histocompatibility antigens (MiHAs) are extremely numerous—possibly up to 720 in mice—and have been regarded as an `immunogenetic nightmare' in transplantation. Here, Claude Perreault, Denis Roy and Claudette Fortin summarize evidence showing that most anti-MiHA T-cell responses are oligoclonal, being restricted to several dominant ...
Claude Perreault +2 more
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Molecular Typing Methods for Minor Histocompatibility Antigens
Methods in Molecular Medicine, 2007Minor histocompatibility (H) antigens crucially affect the outcome of human leukocyte antigen-matched allogeneic stem cell transplantation. The number of molecularly identified minor H antigens is rapidly increasing. In parallel, clinical implementation of minor H antigens for immunotherapy has gained significant interest.
Eric Spierings, Els Goulmy
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Minor histocompatibility antigens: past, present, and future
Tissue Antigens, 2014AbstractMinor histocompatibility (H) antigens are key molecules driving allo‐immune responses in both graft‐versus‐host‐disease (GvHD) and in graft‐versus‐leukemia (GvL) reactivity in human leukocyte antigen (HLA)‐matched hematopoietic stem‐cell transplantation (HSCT).
Eric Spierings
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Presentation and recognition of major and minor histocompatibility antigens
Transplant Immunology, 1994The structural basis of allorecognition is heterogeneous. For minor histocompatibility antigen-specific T cells and for a minority of anti-MHC T cells (indirect allorecognition), the allogeneic molecule acts as any other protein, and is processed and presented as a peptide in the context of self MHC.
A N, Warrens, G, Lombardi, R I, Lechler
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Much ado about minor histocompatibility antigens
Immunology Today, 1998Abstract Current knowledge of histocompatibility (H) loci located outside of the major histocompatibility complex - i.e. those encoding the so-called minor H antigens - was surveyed at a recent meeting ∗ ∗The 1st International Symposium on Minor Histocompatibility Antigens was held at Bar Harbor, ME, USA, on 14–17 September 1997..
Simpson, E, Roopenian, D, Goulmy, E
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