Results 191 to 200 of about 23,181 (258)

Immunosenescence and Vaccine Efficacy in Aging: Dynamic Interplay of Gut Microbiota and mTOR Signaling Pathways

Aging Cell, Volume 25, Issue 6, June 2026.
Aging impairs vaccine efficacy through gut microbiota dysbiosis and mTOR hyperactivation, which together drive inflammaging and weaken immune memory. This review highlights the bidirectional microbiota–mTOR axis and proposes that combining mTOR inhibitors with microbiota modulation offers a promising strategy to enhance vaccine responses in older ...
Jiaxuan Li, Yuhong Zhang, Daijun Yu, Jianhua Li, Keda Chen, Lisheng Chu   +5 more
wiley   +1 more source

Major Histocompatibility Complex Class I Matching is Necessary but not Sufficient for Tolerance Induction to Vascularized Composite Allografts After Donor Hematopoietic Cell Transplantation. [PDF]

Transplant Direct
Manell E, Gunes ME, Merl S, Patwardhan S, Chauhan I, Hong J, Chen B, Jordache P, Almesalmy A, Ekanayake-Alper D, Hajosi D, Husain S, Wuu CS, Wright M, Bogue J, Rohde C, Shanmugarajah K, Cetrulo CL, Sachs DH, Weiner J.   +19 more
europepmc   +1 more source

Allergic Sensitization to Inhalant Allergens in the Upper Respiratory Tract—the B Cell Side

Allergy, Volume 81, Issue 6, Page 1985-2000, June 2026.
ABSTRACT Allergic diseases are on the rise worldwide, driven by respiratory epithelial barrier dysfunction that promotes sensitization to inhalant allergens such as pollen, dust mites, pet dander, and fungal spores. These antigens trigger IgE‐mediated immune responses that lead to diseases such as allergic rhinitis (AR) and asthma.
Ola Grimsholm, Mohammed Zghaebi, Bita Hambrecht, Tanja Kalic, Christopher C. Udoye, Rudolf Manz, Barbara Bohle, Katarzyna M. Sitnik, Julia Eckl‐Dorna, Heimo Breiteneder   +9 more
wiley   +1 more source

Integrative Genomics Identifies Candidate Genes Underlying Trypanotolerance in Hybrid African Cattle

Evolutionary Applications, Volume 19, Issue 6, June 2026.
ABSTRACT Integrative genomics combines data from different omics sources to link genotypes and phenotypes with the aim of unravelling biological networks and pathways that undergird complex traits, particularly with respect to disease. In this respect, integrative genomics, leveraging population and functional genomic data, can be employed to ...
Gillian P. McHugo, James A. Ward, Said Ismael Ng'ang'a, Laurent A. F. Frantz, John A. Browne, Michael Salter‐Townshend, Grace M. O'Gorman, Kieran G. Meade, Emmeline W. Hill, Thomas J. Hall, David E. MacHugh   +10 more
wiley   +1 more source

Tuberculosis Susceptibility and Inbreeding Depression Hinder Ex Situ Conservation in a Critically Endangered Rainforest Bird

Evolutionary Applications, Volume 19, Issue 6, June 2026.
ABSTRACT Captive breeding can be a key component of species conservation strategies, but also exposes these rare species to novel environments including the pathogen landscape. The critically endangered white‐winged wood duck (WWWD) Asarcornis scutulata has experienced substantial population declines, local extirpations and fragmentation of its former ...
Peri E. Bolton, Dustin J. Foote, Nancy E. Drilling, Susan B. McRae, Michael D. Sorenson, Christopher N. Balakrishnan   +5 more
wiley   +1 more source

Occurrence and Impact of Minor Histocompatibility Antigens' Disparities on Outcomes of Hematopoietic Stem Cell Transplantation from HLA-Matched Sibling Donors. [PDF]

Bone Marrow Res, 2012
Dzierzak-Mietla M, Markiewicz M, Siekiera U, Mizia S, Koclega A, Zielinska P, Sobczyk-Kruszelnicka M, Kyrcz-Krzemien S.   +7 more
europepmc   +1 more source

Don't Cut the Cord: Why Umbilical Cord Blood Still Deserves a Place in Transplantation

International Journal of Immunogenetics, Volume 53, Issue 3, Page 229-239, June 2026.
ABSTRACT The use of umbilical cord blood (UCB) as a stem cell source in haematopoietic stem cell transplant (HSCT) has greatly declined in recent years. It has largely been replaced by mismatched unrelated and family donors, facilitated by advances in transplant technologies, including post‐transplant cyclophosphamide to prevent graft‐versus‐host ...
Jenna Nunn, Kay Poulton, Robert Wynn
wiley   +1 more source

Induction of Clinical Operational Tolerance Through Immunosuppression Minimization: Less Is More?

Liver International, Volume 46, Issue 6, June 2026.
ABSTRACT The goal of achieving clinical operational tolerance in liver transplantation has sparked significant interest, driven by the desire to mitigate the long‐term adverse effects of immunosuppression. Advances in understanding the immunological mechanisms underpinning operational tolerance in liver transplantation have highlighted the central role
Emilia Knioła, Bartosz Foroncewicz, Jan Lerut, Leszek Pączek, Krzysztof Mucha   +4 more
wiley   +1 more source

Association of disparities in known minor histocompatibility antigens with relapse-free survival and graft-versus-host disease after allogeneic stem cell transplantation. [PDF]

Biol Blood Marrow Transplant, 2013
Hobo W, Broen K, van der Velden WJ, Greupink-Draaisma A, Adisty N, Wouters Y, Kester M, Fredrix H, Jansen JH, van der Reijden B, Falkenburg JH, de Witte T, Preijers F, Schattenberg T, Feuth T, Blijlevens NM, Schaap N, Dolstra H.   +17 more
europepmc   +1 more source

Addressing racial disparities in representation across blood, stem cell and organ and tissue donor pools

Vox Sanguinis, Volume 121, Issue 6, Page 710-721, June 2026.
Abstract Background and Objectives Adequate representation of donors from diverse ancestral populations in blood, stem cell and organ transplantation is critical to ensuring equitable access to these lifesaving therapies. Because of population‐level differences in genetic markers, patients from racialized groups may have unique transfusion and ...
Bonnie Lu, Sylvia Okonofua, Farnaz Farahbakhsh, Rupal Hatkar, Lauren Sano, Margarita Conway, Marie‐Claire Kapesa, Manuel Escoto, Murdoch Leeies, Warren B. Fingrut   +9 more
wiley   +1 more source