Results 61 to 70 of about 13,606 (275)

DORĘCZENIA PISM PROCESOWYCH (UWAGI NA MARGINESIE CTH. 2,4,1 [A. 318/319] = C. 5,4,20)

open access: yesZeszyty Prawnicze, 2016
THE NATURAL SCIENCES IN THE SERVICE OF PLEADINGS IN CASES INVOLVING MINORS: REMARKS ON CTH 2.4.1 [A. 318/319] = C. 5.4.20) Summary The subject of this article is the status of juvenile persons in Roman law, as exemplified by one of the constitutions ...
Jacek Wiewiorowski
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

open access: yesMolecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

The island of Gozo in classical texts [PDF]

open access: yes, 1995
Way back in 1971, J. Busuttil (1971) had already referred to Gozo as Gaulos or Gaudos among the Greeks, Gaulos or Gaulus among the Romans, and Gaul among the Carthaginians.
Vella, Horatio Caesar Roger
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

"Bonshommes”, (the “new people”) and the pre-communal “conspiracy”. XI-XII Centuries

open access: yesMontesquieu.it, 2018
In the crisis of the ancient political and ecclesiastical orders, which represented a true crisis in the legitimacy of the traditional authorities (Regnum e Sacerdotium fighting for universal supremacy), a profound and dramatic crisis for the medieval ...
Rita Bellelli
doaj   +1 more source

"Terrae motus factus est”: earthquakes in Switzerland before A.D. 1000. A critical approach [PDF]

open access: yes, 2018
We focus on Swiss earthquakes in antiquity and the early medieval period before A.D. 1000. We have information on less than half a dozen earthquakes within this era, since written records for the first half of the first millennium A.D.
Fäh, Donat   +2 more
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

« Ne pas parler à la place des premiers concernés ». Étude d’une pratique politique d’éthique langagière chez des militants politiques pour les droits des étrangers en France

open access: yesNouvelle Revue Synergies Canada, 2022
Les mobilisations pour les droits des étrangers sont parfois le cadre de pratiques langagières reposant sur une idéologie langagière caractérisant la parole politique comme une voie d’émancipation possible. On s’intéressera en particulier à une pratique,
Marie Veniard
doaj  

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