Results 101 to 110 of about 482,752 (300)

Prognostic value of circulating microRNA-210 levels in patients with moderate to severe aortic stenosis. [PDF]

PLoS ONE, 2014
Circulating micro-RNAs have been proposed as a novel class of cardiovascular (CV) biomarkers, but whether they meet analytical requirements and provide additional information to establish risk indices have not been established.
Helge Røsjø, Mai Britt Dahl, Anja Bye, Johanna Andreassen, Marit Jørgensen, Ulrik Wisløff, Geir Christensen, Thor Edvardsen, Torbjørn Omland   +8 more
doaj   +1 more source

The functional and predictive roles of miR-210 in cryptorchidism

Scientific Reports, 2016
AbstractIdiopathic diseases of the reproductive system are important factors leading to male infertility. Many studies have shown that microRNAs (miRNAs) regulate the expression of multiple genes that play a significant role in spermatogenesis and development. We previously showed that microRNA-210 (miR-210) is one of the markedly upregulated microRNAs
Zhengzheng Duan, Helong Huang, Fei Sun
openaire   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Exosomes derived from cancer stem cells of gemcitabine-resistant pancreatic cancer cells enhance drug resistance by delivering miR-210

Cellular Oncology, 2019
Gemcitabine (GEM)-based chemotherapy is the first-line treatment for locally advanced pancreatic cancer. GEM resistance, however, remains a significant clinical challenge.
Zhiyong Yang, Ning Zhao, Jing Cui, Heshui Wu, J. Xiong, T. Peng   +5 more
semanticscholar   +1 more source

OSCC Exosomes Regulate miR-210-3p Targeting EFNA3 to Promote Oral Cancer Angiogenesis through the PI3K/AKT Pathway

BioMed Research International, 2020
This study is aimed at determining how oral squamous cell carcinoma (OSCC) regulates the angiogenesis of HUVECs through miR-210-3p expression and exploring the relationship among miR-210-3p, its target protein, and the possible mechanism of angiogenesis ...
Hui Wang, Lin Wang, Xiaocheng Zhou, Xinyue Luo, Ke Liu, Erhui Jiang, Yang Chen, Z. Shao, Z. Shang   +8 more
semanticscholar   +1 more source

MiR-210-3p Enhances Cardiomyocyte Apoptosis and Mitochondrial Dysfunction by Targeting the NDUFA4 Gene in Sepsis-Induced Myocardial Dysfunction.

International Heart Journal, 2021
Sepsis-induced myocardial dysfunction (SIMD) is a common complication with high incidence rates in sepsis patients. This study aimed to investigate the roles of miR-210-3p in regulating cardiomyocyte apoptosis and mitochondrial dysfunction associated ...
Dan-Dan Chen, Y. Hou, Xing-Jun Cai
semanticscholar   +1 more source

HBV infection suppresses the expression of inflammatory macrophage miR‑210

Molecular Medicine Reports, 2018
It has been previously reported that hepatitis B e‑antigen (HBeAg) induces microRNA (miR)‑155 expression and promotes liver injury by increasing inflammatory cytokine production in macrophages. Moreover, it was previously demonstrated that miR‑210 alleviates lipopolysaccharide‑stimulated proinflammatory cytokine production in macrophages.
Feifei, Li, Hongjun, Bian, Wenwen, Wang, Liping, Ning, Miao, Xu, Shuohuan, Sun, Wanhua, Ren, Chengyong, Qin, Jianni, Qi   +8 more
openaire   +3 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

miR-210 promotes IPF fibroblast proliferation in response to hypoxia

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2014
Idiopathic pulmonary fibrosis (IPF) is characterized by the relentless spread of fibroblasts from scarred alveoli into adjacent alveolar units, resulting in progressive hypoxia and death by asphyxiation. Although hypoxia is a prominent clinical feature of IPF, the role of hypoxia as a driver of the progressive fibrotic nature of the disease has not ...
Vidya, Bodempudi, Polla, Hergert, Karen, Smith, Hong, Xia, Jeremy, Herrera, Mark, Peterson, Wajahat, Khalil, Judy, Kahm, Peter B, Bitterman, Craig A, Henke   +9 more
openaire   +3 more sources

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source