Results 111 to 120 of about 482,752 (300)

MicroRNA‐210 Promotes Accumulation of Neural Precursor Cells Around Ischemic Foci After Cerebral Ischemia by Regulating the SOCS1–STAT3–VEGF‐C Pathway

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundNeural precursor cell (NPC) migration toward lesions is key for neurological functional recovery. The neovasculature plays an important role in guiding NPC migration.
Zhao‐You Meng, Hua‐Li Kang, Wei Duan, Jian Zheng, Qian‐Ning Li, Zhu‐Juan Zhou   +5 more
doaj   +1 more source

Down-regulation of TIMP2 by HIF-1α/miR-210/HIF-3α regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma [PDF]

, 2016
Cancer metastasis is a multistep process that involves a series of tumor-stromal interaction, including extracellular matrix (ECM) remodeling, which requires a concerted action of multiple proteolytic enzymes and their endogenous inhibitors.
Chan, LK, Kai, AKL, Lee, MF, Lo, CLR, Ng, IOL, Wong, CCL, Wong, CM   +6 more
core   +1 more source

miR-210 in Exosomes Derived from Macrophages under High Glucose Promotes Mouse Diabetic Obesity Pathogenesis by Suppressing NDUFA4 Expression

Journal of Diabetes Research, 2020
Objective Type 2 diabetes mellitus (T2DM) is featured by insulin resistance and lipid metabolism dysregulation. A large number of miRNAs were identified in exosomes derived from adipose tissue macrophages associated with T2DM pathogenesis, but its ...
Fengshun Tian, Ping Tang, Zhilian Sun, Ruihui Zhang, Danhua Zhu, Junying He, Jixing Liao, Qinghua Wan, Jie Shen   +8 more
semanticscholar   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Simultaneous miRNA and mRNA transcriptome profiling of human myoblasts reveals a novel set of myogenic differentiation-associated miRNAs and their target genes [PDF]

, 2013
Background: miRNA profiling performed in myogenic cells and biopsies from skeletal muscles has previously identified miRNAs involved in myogenesis. Results: Here, we have performed miRNA transcriptome profiling in human affinity-purified CD56+ myoblasts ...
Barat, A, Carnac, G, Dessen, P, Dmitriev, P, Laoudj-Chenivesse, D, Lazar, V, Lipinski, M, O'Connell, MJ, Polesskaya, A, Robert, T, Turki, A, Vassetzky, YS, Walsh, TA   +12 more
core   +5 more sources

miR‐210 is induced by hypoxia and regulates neural cell adhesion molecule in prostate cells [PDF]

, 2020
Hypoxia in prostate tumours has been associated with disease progression andmetastasis. MicroRNAs are short noncoding RNA molecules that are important inseveral cell processes, but their role in hypoxic signalling is still poorly understood.miR‐210 has ...
Angel, Charlotte Zoe, Lynch, Seodhna M, McKenna, Declan J, McKenna, Michael M., Nesbitt, Heather, Walsh, CP   +5 more
core   +2 more sources

Anti-inflammatory effects of paeoniflorin caused by regulation of the hif1a/miR-210/caspase1/GSDMD signaling pathway in astrocytes: a novel strategy for hypoxia-induced brain injury in rats

Immunopharmacology and immunotoxicology, 2021
Context: Hypoxia-induced injury is a classic symptom of obstructive sleep apnea hypopnea syndrome (OSAHS), which is a risk factor of various diseases, such as hypertension, heart failure and stroke.
Zhenxiu Jiang, Jun Chen, Jiangjun Chen, Ze-lin Lei, Hailin Chen, Jiqiang Wu, Xue Bai, Pingping Wanyan, Qin Yu   +8 more
semanticscholar   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

MicroRNA-210 Protects PC-12 Cells Against Hypoxia-Induced Injury by Targeting BNIP3

Frontiers in Cellular Neuroscience, 2017
MicroRNA (miR)-210 is the most consistently and predominantly up-regulated miR in response to hypoxia in multiple cancer cells. The roles of miR-210 in rat adrenal gland pheochromocytoma (PC-12) cells remain unknown.
Yonggang Luan, Xiaoli Zhang, Yongli Zhang, Yubin Dong   +3 more
doaj   +1 more source

Various levels of circulating exosomal total-miRNA and miR-210 hypoxamiR in different forms of pregnancy hypertension [PDF]

, 2017
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Alasztics, Bálint, Biró, Orsolya, Joó, József Gábor, Molvarec, Attila, Nagy, Bálint, Rigó, János   +5 more
core   +1 more source