Results 141 to 150 of about 274,131 (166)

MiR‐370‐3p inhibits the development of human endometriosis by downregulating EDN1 expression in endometrial stromal cells

Cell Biology International, 2021
AbstractMiR‐370‐3p has been demonstrated to be downregulated in patients with endometriosis (EM). However, its role and molecular mechanisms in the progression of EM remain unclear. Real‐time polymerase chain reaction was used to measure the expression of miR‐370‐3p and endothelin‐1 (EDN1) in patients with or without EM. After miR‐370‐3p overexpression
Juan Liu
exaly   +3 more sources

CircSPI1_005 ameliorates osteoarthritis by sponging miR-370-3p to regulate the expression of MAP3K9

International Immunopharmacology, 2022
Osteoarthritis (OA), caused by the destruction of joint cartilage, is the most prevalent form of arthritis, causing pain and stiffness in joints among millions of patients worldwide. Increasing evidence suggests that non-coding RNAs, including circular RNAs, play important roles in the pathogenesis of OA, but the precise signaling pathway is still ...
Jian-Lin, Zhou, Shuang, Deng, Hong-Song, Fang, Hao, Peng, Qiong-Jie, Hu   +4 more
openaire   +2 more sources

Mir-370-3p Impairs Glioblastoma Stem-Like Cell Malignancy Regulating a Complex Interplay between HMGA2/HIF1A and the Oncogenic Long Non-Coding RNA (lncRNA) NEAT1 [PDF]

International Journal of Molecular Sciences, 2020
Glioblastoma (GBM) is the most aggressive and prevalent form of a human brain tumor in adults. Several data have demonstrated the implication of microRNAs (miRNAs) in tumorigenicity of GBM stem-like cells (GSCs).
Valentina Lulli, Mariachiara Buccarelli, Ramona Ilari   +2 more
exaly   +3 more sources

Increased plasma miR-370-3p expression in poor-outcome patients with pancreatic ductal adenocarcinoma

Pancreatology, 2023
To determine whether circulating microRNAs (miRNAs) can be used as prognostic biomarkers for pancreatic ductal adenocarcinoma (PDAC).Patients with PDAC (N = 120) who underwent surgical resection at Hiroshima University Hospital between November 2006 and January 2020 were enrolled in this study and grouped based on their overall survival (OS) into two ...
Takumi Harada, Kenichiro Uemura, Tatsuaki Sumiyoshi, Ryuta Shintakuya, Kenjiro Okada, Tetsuhiro Hara, Shinya Takahashi, Eiso Hiyama   +7 more
openaire   +2 more sources

MicroRNA hsa-miR-370-3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation [PDF]

Biochemical Pharmacology, 2017
Cytochrome P450 2D6 (CYP2D6) participates in the metabolism of approximately 20-25% of prescribed drugs. Genetic polymorphisms influence the expression and/or activity of CYP2D6, and inter-individual differences in drug activation and elimination caused by CYP2D6 genetic variants were reported. However, little is known about the potential modulation of
Linjuan Zeng, Yinting Chen, Li-Rong Yu   +2 more
exaly   +3 more sources

CIRC_0114428 INFLUENCES THE PROGRESSION OF SEPTIC ACUTE KIDNEY INJURY VIA REGULATING MIR-370-3P/TIMP2 AXIS

Shock, 2023
ABSTRACT Background: Septic acute kidney injury (AKI) is a serious complication of sepsis, which greatly threatened the life safety of critically ill patients. Recently, circular RNA is considered to be implicated in sepsis-induced renal cell damage. However, the role of circ_0114428 in sepsis AKI is still unclear.
Bihong, Zhang, Ting, You, Yu, Liu, Pei, Li   +3 more
openaire   +2 more sources

The oncogenic role of the circ_0003997/miR-370-3p/HMGA2 axis in papillary thyroid cancer

Endocrine
Papillary thyroid cancer (PTC) is the most common endocrine malignancy, demonstrating the most rapid incidence growth among solid tumors in the past decades. Notably, aggressive variants frequently manifest metastatic potential and therapeutic resistance, substantially compromising poor prognosis.
Jing, Ma, Juxiang, Liu, Changhong, Dong, Jun, Wang, Limin, Tian, Jinxing, Quan   +5 more
openaire   +2 more sources

Emerging roles of circUBAP2 targeting miR-370-3p in proliferation, apoptosis, and invasion of papillary thyroid cancer cells

Human Cell, 2021
Circular RNAs (circRNAs) have been documented to be aberrantly expressed in many types of malignancies and involved in cancer progression. However, their role in thyroid cancer (TC) remains largely unknown. Our study aimed to explore the role and mechanism of circUBAP2 in TC.
Hui, Xiong, Jinsong, Yu, Guangwei, Jia, Yang, Su, Jianliang, Zhang, Qiu, Xu, Xiaoxiong, Sun   +6 more
openaire   +2 more sources

CXCL12-regulated miR-370–3p functions as a tumor suppressor gene by targeting HMGA2 in nonfunctional pituitary adenomas

Molecular and Cellular Endocrinology, 2019
Silencing of noncoding genes within the imprinted DLK1-MEG3 locus is exclusive to human nonfunctional pituitary adenomas (NFPAs), but the exact mechanism is still unclear. This study was designed to demonstrate the impact of CXCL12 on the expression of miRNAs within this locus and phenotypic alterations of NFPAs.
Feng Cai, Xiaohai Liu, Renzhi Wang
exaly   +3 more sources

Circ-NMNAT1 Drives Tumor Progression in Bladder Cancer by Modulating the miR-370-3p/ATXN2L Axis

Applied Biochemistry and Biotechnology
The relationship between circular RNAs (circRNAs) and tumor growth and metastasis is increasingly well-established. In this study, we sought to shed light on circ-NMNAT1's potential molecular mechanisms in bladder cancer (BCa). circ-NMNAT1, miR-370-3p, and ATXN2L expression profiles were explored using RT-qPCR and/or Western blot techniques.
ChenHui Zhu, LiJuan Lin, ChangQing Huang, ZhaoGuan Li   +3 more
openaire   +2 more sources