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Can MicroRNAs serve as reliable biomarkers and novel therapeutic targets in age-related macular degeneration? A systematic review and meta-analysis. [PDF]

J Transl Med
Chen KY, Chan HC, Chan CM.
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TTF-1-regulated miR-532-5p targets KRAS and MKL2 oncogenes and induces　apoptosis in lung adenocarcinoma cells

TTF-1-regulated miR-532-5p targets KRAS and MKL2 oncogenes and induces　apoptosis in lung adenocarcinoma cells
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Identification of Mir-532-5p As a Reliable miRNA Reference in Acute Lymphoblastic Leukemia

Blood, 2023
In acute lymphoblastic leukemia (ALL) cure rates have reached >90%, however, therapy resistance and relapses occur. Hence, the major interest in leukemia research is the understanding of ALL biology and, based on that, the development of new targeted therapies. As patient-derived xenograft (PDX) mouse models, such as the NOD/SCID/
Teresa Mack, Klaus-Michael Debatin, Lueder Hinrich Meyer, Vera Münch   +3 more
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Neuroprotective effects of miR-532-5p against ischemic stroke

Metabolic Brain Disease, 2020
Stroke can cause death and disability and has a high incidence with many complications. So far, effective treatment options for stroke are still limited. MicroRNA-532-5p (miR-532-5p) is significantly downregulated in stroke. However, the role of miR-532-5p in ischemic stroke is still unclear.
Jingwei Mu, Xi Cheng, Shanshan Zhong, Xiaohong Chen, Chuansheng Zhao   +4 more
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MiR-532-5p Suppresses Migration and Invasion of Lung Cancer Cells Through Inhibiting CCR4

Cancer Biotherapy and Radiopharmaceuticals, 2020
Background: Studies showed that miR-532-5p suppresses proliferation and induces apoptosis of lung cancer (LC) cells; its role in LC is not fully understood. Therefore, this research aimed to reveal the effect and mechanism of miR-532-5p on migration and invasion of LC cells.
Jingjing, Hu, Lu, Wang, Caihong, Guan
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CircCHMP5 Contributes to Ox-LDL-induced Endothelial Cell Injury Through the Regulation of MiR-532-5p/ROCK2 axis

Cardiovascular Drugs and Therapy, 2022
Aberrant expression of circular RNA (circRNA) has been demonstrated to be related to atherosclerosis (AS) formation. However, the mechanism of circCHMP5 (also known as hsa_circ_0003575) in AS formation remains unclear.Oxidized low-density lipoprotein (ox-LDL) was used to treat human umbilical vein endothelial cells (HUVECs) to construct a cell injury ...
Xia Li, Xiaoli Kang, Yali Di, Shuxian Sun, Liming Yang, Bin Wang, Zheng Ji   +6 more
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miR-532-5p Inhibits Non-Small Cell Lung Cancer Progression In Vivo and In Vitro by Targeting Yin Yang 1

Critical Reviews in Eukaryotic Gene Expression, 2022
Lung cancer is a common cancer that is familiar to people and has the highest global incidence; among all lung cancer patients, 85% are non-small cell lung cancer (NSCLC). A number of microRNAs (miRNAs), including miR-532-5p, are implicated in the pathophysiological processes of tumorigenesis.
Song, Li, Chunlin, Zhu, Quandong, Wang, Yongsi, Wen   +3 more
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MiR-532-5p alleviates hypoxia-induced cardiomyocyte apoptosis by targeting PDCD4

Gene, 2018
MicroRNAs (miRNAs) are a class of endogenous non-coding RNAs involved in regulating various biological processes at the post-transcription level. Accumulating evidence suggests that hypoxia caused by acute myocardial infarction induces cardiomyocyte damage including apoptosis.
Jideng, Ma, Jinwei, Zhang, Yujie, Wang, Keren, Long, Xun, Wang, Long, Jin, Qianzi, Tang, Li, Zhu, Guoqing, Tang, Xuewei, Li, Mingzhou, Li   +10 more
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A genetic variant located in the miR-532-5p-binding site of TGFBR1 is associated with the colorectal cancer risk

Journal of Gastroenterology, 2018
Genome-wide association studies have identified genes in the transforming growth factor-β (TGFβ) signaling pathway that are responsible for regulating carcinogenesis.We searched for single-nucleotide polymorphisms (SNPs) located within 3'-untranslated regions (3'-UTRs) that might affect the ability of miRNAs to bind genes in the TGFβ pathway for ...
Dongying, Gu, Shuwei, Li, Mulong, Du, Cuiju, Tang, Haiyan, Chu, Na, Tong, Zhengdong, Zhang, Meilin, Wang, Jinfei, Chen   +8 more
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