Results 171 to 180 of about 5,056 (201)

CircCHMP5 Contributes to Ox-LDL-induced Endothelial Cell Injury Through the Regulation of MiR-532-5p/ROCK2 axis

Cardiovascular Drugs and Therapy, 2022
Aberrant expression of circular RNA (circRNA) has been demonstrated to be related to atherosclerosis (AS) formation. However, the mechanism of circCHMP5 (also known as hsa_circ_0003575) in AS formation remains unclear.Oxidized low-density lipoprotein (ox-LDL) was used to treat human umbilical vein endothelial cells (HUVECs) to construct a cell injury ...
Xia Li, Xiaoli Kang, Yali Di, Shuxian Sun, Liming Yang, Bin Wang, Zheng Ji   +6 more
openaire   +2 more sources

MiR-532-5p Suppresses Migration and Invasion of Lung Cancer Cells Through Inhibiting CCR4

Cancer Biotherapy and Radiopharmaceuticals, 2020
Background: Studies showed that miR-532-5p suppresses proliferation and induces apoptosis of lung cancer (LC) cells; its role in LC is not fully understood. Therefore, this research aimed to reveal the effect and mechanism of miR-532-5p on migration and invasion of LC cells.
Jingjing, Hu, Lu, Wang, Caihong, Guan
openaire   +2 more sources

miR-532-5p Inhibits Non-Small Cell Lung Cancer Progression In Vivo and In Vitro by Targeting Yin Yang 1

Critical Reviews in Eukaryotic Gene Expression, 2022
Lung cancer is a common cancer that is familiar to people and has the highest global incidence; among all lung cancer patients, 85% are non-small cell lung cancer (NSCLC). A number of microRNAs (miRNAs), including miR-532-5p, are implicated in the pathophysiological processes of tumorigenesis.
Song, Li, Chunlin, Zhu, Quandong, Wang, Yongsi, Wen   +3 more
exaly   +3 more sources

MiR-532-5p alleviates hypoxia-induced cardiomyocyte apoptosis by targeting PDCD4

Gene, 2018
MicroRNAs (miRNAs) are a class of endogenous non-coding RNAs involved in regulating various biological processes at the post-transcription level. Accumulating evidence suggests that hypoxia caused by acute myocardial infarction induces cardiomyocyte damage including apoptosis.
Jideng, Ma, Jinwei, Zhang, Yujie, Wang, Keren, Long, Xun, Wang, Long, Jin, Qianzi, Tang, Li, Zhu, Guoqing, Tang, Xuewei, Li, Mingzhou, Li   +10 more
openaire   +2 more sources

A genetic variant located in the miR-532-5p-binding site of TGFBR1 is associated with the colorectal cancer risk

Journal of Gastroenterology, 2018
Genome-wide association studies have identified genes in the transforming growth factor-β (TGFβ) signaling pathway that are responsible for regulating carcinogenesis.We searched for single-nucleotide polymorphisms (SNPs) located within 3'-untranslated regions (3'-UTRs) that might affect the ability of miRNAs to bind genes in the TGFβ pathway for ...
Dongying, Gu, Shuwei, Li, Mulong, Du, Cuiju, Tang, Haiyan, Chu, Na, Tong, Zhengdong, Zhang, Meilin, Wang, Jinfei, Chen   +8 more
openaire   +2 more sources

Circ_0007841 knockdown confers cisplatin sensitivity to ovarian cancer cells by down-regulation of NFIB expression in a miR-532-5p-dependent manner

Journal of Chemotherapy, 2022
Cisplatin (DDP) is first-line management for ovarian cancer (OC). Previous data have suggested that circular RNA_0007841 (circ_0007841) regulates OC progression; however, there is no data on its role in the sensitivity of OC cells to DDP. RNA expression of circ_0007841, microRNA-532-5p (miR-532-5p) and nuclear factor I B (NFIB) was detected by ...
Yuan, Gao, Yan, Huang
openaire   +2 more sources

Bone marrow mesenchymal stem cells‐derived exosomes mediate nuclear receptor coactivator‐3 expression in osteoblasts by delivering miR‐532‐5p to influence osteonecrosis of the femoral head development

Cell Biology International, 2022
AbstractExosomes (Exo) originated from bone marrow mesenchymal stem cells (BMSCs) have therapeutic impacts on osteonecrosis of the femoral head (ONFH), and microRNA (miR)‐532‐5p has been confirmed to participate in ONFH progression. In the research, it was figured out whether BMSCs‐Exo could relieve ONFH by delivering miR‐532‐5p.
XiaoYong Lan, HaiPing Ma, YiPin Xiong, LingFeng Zou, Zhen Yuan, YuHong Xiao   +5 more
openaire   +2 more sources

Downregulation of miR-27a* and miR-532-5p and Upregulation of miR-146a and miR-155 in LPS-induced RAW264.7 Macrophage Cells

Inflammation, 2012
MicroRNAs (miRNAs) are short non-coding RNAs that are involved in the epigenetic regulation of cellular processes. To identify more miRNAs which are involved in the macrophage inflammatory response to lipopolysaccharide (LPS) stimulation and dissect the mechanisms more clearly, microRNA profiling of LPS-treated RAW264.7 macrophage cells was performed ...
Ying, Cheng, Wenhua, Kuang, Yongchang, Hao, Donglin, Zhang, Ming, Lei, Li, Du, Hanwei, Jiao, Xiaoru, Zhang, Fengyang, Wang   +8 more
openaire   +2 more sources

circSKIL promotes osteoblastic differentiation of periodontal ligament cells by sponging miR‐532‐5p to activate Notch signaling

Journal of Periodontal Research, 2022
AbstractBackground and objectivePeriodontal ligament cells (PDLCs) possess the capacity to differentiate into a variety of cell types to benefit periodontal regeneration. In this study, we examined the circSKIL/miR‐532‐5p/Notch1 axis in controlling the osteoblastic differentiation of PDLCs.MethodsPrimary human PDLCs (hPDLCs) were isolated and induced ...
Xiaohuan, Zhong, Huixin, Wang
openaire   +2 more sources

LncRNA JHDM1D‐AS1 promotes osteogenic differentiation of periodontal ligament cells by targeting miR‐532‐5p to activate IGF1R signaling

Journal of Periodontal Research, 2023
AbstractObjectiveThe aim of this study was to explore the mechanism underlying periodontal ligament cells (PDLCs) osteogenic differentiation.BackgroundPeriodontitis causes damage to tooth‐supporting apparatus and eventually leads to tooth loss. PDLCs hold great promise in periodontal regeneration due to their osteogenic features.MethodsThe expression ...
Xiaohuan, Zhong, Huixin, Wang
openaire   +2 more sources