miR-543 inhibits tumor malignant progression by regulating TWIST1 in human gastric cancer [PDF]
, 2020 Abstract Background: TWIST1, a highly conserved basic helix-loop-helix (bHLH) transcription factor, is essential to epithelial-mesenchymal transition (EMT) and cancer metastasis in gastric cancer (GC). However, little is known about the post-transcriptional regulation of TWIST1, especially the mechanisms involving microRNAs.
Guoda Lian +9 more
openaire +1 more source
Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria [PDF]
, 2016 Malaria remains one of the greatest public health challenges worldwide, particularly in sub-Saharan Africa. The clinical outcome of individuals infected with Plasmodium falciparum parasites depends on many factors including host systemic inflammatory ...
A Bhoumik +64 more
core +1 more source
Cells, 2023 The inhibition of mammalian target of rapamycin (mTOR) with rapamycin (RAPA) provides protection against myocardial ischemia/reperfusion (I/R) injury in diabetes.
Arun Samidurai +6 more
doaj +1 more source
Identification of particular groups of microRNAs that positively or negatively impact on beta cell function in obese models of type 2 diabetes. [PDF]
, 2013 AIMS/HYPOTHESIS: MicroRNAs are key regulators of gene expression involved in health and disease. The goal of our study was to investigate the global changes in beta cell microRNA expression occurring in two models of obesity-associated type 2 diabetes ...
Guay, C. +7 more
core +2 more sources
MicroRNA Profiling in the Medial and Lateral Habenula of Rats Exposed to the Learned Helplessness Paradigm: Candidate Biomarkers for Susceptibility and Resilience to Inescapable Shock. [PDF]
PLoS ONE, 2016 Depression is a highly heterogeneous disorder presumably caused by a combination of several factors ultimately causing the pathological condition. The genetic liability model of depression is likely to be of polygenic heterogeneity.
Katrine Svenningsen +8 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2023 Accurate spinal tuberculosis (TB) diagnosis is of utmost importance for adequately treating and managing the disease. Given the need for additional diagnostic tools, this study aimed to investigate the utility of host serum miRNA biomarkers for ...
Qiang Liang +10 more
doaj +1 more source
Signature of microRNA expression during osteogenic differentiation of bone marrow MSCs reveals a putative role of miR-335-5p in osteoarthritis [PDF]
, 2015 Background: The aim of this study was to evaluate, the existence of a signature of differentially expressed microRNAs (miRNAs) during osteogenic differentiation of bone marrow MSCs from OA and healthy donors and to describe their possible implication ...
Benjamín Fernández-Gutiérrez +10 more
core +6 more sources
Genetic networks in Parkinson's and Alzheimer's disease [PDF]
, 2020 Parkinson\u27s disease (PD) and Alzheimer\u27s disease (AD) are the most common neurodegenerative diseases and there is increasing evidence that they share common physiological and pathological links.
Carroll, Camilla +4 more
core +3 more sources
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
Characteristics of binding sites of intergenic, intronic and exonic miRNAs with mRNAs of oncogenes coding intronic miRNAs [PDF]
, 2013 International audienceThe interaction of 784 intergenic (ig-miRNA), 686 intronic (in-miRNA) and 49 exonic miRNAs (ex-miRNA) with mRNAs of 51 oncogenes coding in-miRNAs was investigated.
Berillo, Olga +3 more
core +2 more sources