MicroRNA-543 in systemic diseases and possible applications in gynecologic tumors
Reproductive and Developmental Medicine, 2021 In recent years, an increasing number of young women have been diagnosed with cancer, including some nulliparous women. Therefore, many young patients with early-stage cancer desire to preserve fertility after cytotoxic oncological treatments.
Yan-Ran Sheng +5 more
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World Journal of Surgical Oncology, 2021 Background The study was done to investigate the effect of LncRNA MEG3 on the immunity and autophagy of non-small cell lung carcinoma through the IDO signaling pathway. Methods A total of 78 cases of early NSCLC patients (research group; RG) and 69 cases
Chuanqiang Wang +2 more
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Zhongliu Fangzhi Yanjiu, 2021 Objective To investigate the role of LncRNAs-MEG3 in the carcinogenesis and progression of nasopharyngeal carcinoma (NPC) and the possible molecular mechanism. Methods qRT-PCR was used to detect the content of MEG3 and miR-543 in NPC cells.
NING Jiayu +4 more
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Frontiers in Neuroinformatics, 2022 ObjectiveIn our research we try to explore whether glioma stem cell containing circRNAs signal pathway could regulate glioma malignant progression and elaborate its possible mechanism.MethodsIn this study, we used biological information analysis to build
Li Guowei, Jin Yanping
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Metabolic stress-induced microRNA and mRNA expression profiles of human fibroblasts [PDF]
, 2014 Metabolic and oxidative stresses induce physiological adaptation processes, disrupting a finely tuned, coordinated network of gene expression. To better understand the interplay between the mRNA and miRNA transcriptomes, we examined how two distinct ...
Akin +38 more
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Integrated analysis of lncRNA-associated ceRNA network identified potential regulatory interactions in osteosarcoma [PDF]
Genetics and Molecular Biology, 2020 This study aimed to identify potential therapeutic targets in osteosarcoma (OS) through the network analysis of competing endogenous RNAs (ceRNAs). The differentially expressed miRNAs (DEMIs) and mRNAs (DEMs) were identified between OS cell lines and ...
Yongwei Wang +3 more
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Design of crRNA to Regulate MicroRNAs Related to Metastasis in Colorectal Cancer Using CRISPR-C2c2 (Cas13a) Technique [PDF]
Cell Journal, 2023 Colorectal cancer (CRC) is the third most prevalent cancer with the second-highest mortality rate worldwide. microRNAs(miRNAs) of cancer-derived exosomes have shown promising diagnosis potential.
Seyed Taleb Houseini +4 more
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A Regulatory Circuitry Between Gria2, miR-409, and miR-495 Is Affected by ALS FUS Mutation in ESC-Derived Motor Neurons [PDF]
, 2018 Mutations in fused in sarcoma (FUS) cause amyotrophic lateral sclerosis (ALS). FUS is a multifunctional protein involved in the biogenesis and activity of several types of RNAs, and its role in the pathogenesis of ALS may involve both direct effects of
Biscarini, Silvia +10 more
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A statistically inferred microRNA network identifies breast cancer target miR-940 as an actin cytoskeleton regulator [PDF]
, 2015 International audienceMiRNAs are key regulators of gene expression. By binding to many genes, they create a complex network of gene co-regulation. Here, using a network-based approach, we identified miRNA hub groups by their close connections and common ...
Bhajun, Ricky +9 more
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Kinetics of the chromosome 14 microRNA cluster ortholog and its potential role during placental development in the pregnant mare [PDF]
, 2018 Background: The human chromosome 14 microRNA cluster (C14MC) is a conserved microRNA (miRNA) cluster across eutherian mammals, reported to play an important role in placental development.
Ball, Barry A +6 more
core +5 more sources