Results 71 to 80 of about 215,132 (245)

MicroRNAs in cardiac arrhythmia: DNA sequence variation of MiR-1 and MiR-133A in long QT syndrome.

, 2014
Long QT syndrome (LQTS) is a genetic cardiac condition associated with prolonged ventricular repolarization, primarily a result of perturbations in cardiac ion channels, which predisposes individuals to life-threatening arrhythmias.
Corfield, VA, Christiansen, M, Corfield, Valerie A, Christiansen, Kasper M, Carlsen, AL, Christiansen, KM, Carlsen, Anting L, Behr, Elijah R, Kanters, JK, Hedley, Paula L, Kanters, Jørgen K., Christiansen, Michael, Behr, ER, Hedley, PL   +13 more
core   +1 more source

Large Faraday Rotation in Liquid Crystals With Embedded Paramagnetic Ions (Cu2+, VO2+) at Room Temperature

Advanced Optical Materials, EarlyView.
Large Faraday rotation at room temperature is observed in thin films of discotic copper (Cu2+: 3d9) and vanadyl (VO2+: 3d1) enaminoketone complexes. The large Verdet constant originates from a high density of paramagnetic centers, metal‐ligand p−d hybridization and π orbitals involved in optical transitions (identified by DFT calculations), as well as ...
Karolina Łempicka‐Mirek, Adam Krówczyński, Mateusz Król, Nevill Gonzalez Szwacki, Paulina Rybak, Damian Pociecha, Paweł W. Majewski, Barbara Piętka, Jacek Szczytko   +8 more
wiley   +1 more source

Bridging Boltzmann and Non‐Boltzmann Optical Thermometry Enabled by Multimodal Perovskite Nanocrystals

Advanced Optical Materials, EarlyView.
Multimodal perovskite nanocrystals enable optical thermometry across multiple excitation and emission regimes, spanning the UV–Vis–NIR spectral range. By combining upconversion, downshifting, and persistent luminescence, the platform bridges conventional Boltzmann and non‐Boltzmann thermometric approaches.
Adrian Drozdowski, Kevin Soler‐Carracedo, Tomasz Grzyb   +2 more
wiley   +1 more source

miR-543 inhibits tumor malignant progression by regulating TWIST1 in human gastric cancer [PDF]

, 2020
Abstract Background: TWIST1, a highly conserved basic helix-loop-helix (bHLH) transcription factor, is essential to epithelial-mesenchymal transition (EMT) and cancer metastasis in gastric cancer (GC). However, little is known about the post-transcriptional regulation of TWIST1, especially the mechanisms involving microRNAs.
Guoda Lian, Xuanna Li, Shaojie Chen, Jiajia Li, Yaqing Li, Shangxiang Chen, Xiangan Lin, Haoming Lin, Kaihong Huang, Yinting Chen   +9 more
openaire   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Identification of a novel necroptosis-associated miRNA signature for predicting the prognosis in head and neck squamous cell carcinoma

Open Medicine, 2022
Head and neck squamous cell carcinoma (HNSCC) is one of the most aggressive malignancies that have a poor prognosis. Necroptosis has been demonstrated in recent years to be a form of inflammatory cell death occurring in multicellular organism, which ...
Guan Jiezhong, Liu Xinyu, Wang Kang, Jia Yiqun, Yang Bo   +4 more
doaj   +1 more source

mir-am/LightTwinSVM: LightTwinSVM 0.6.0

, 2019
Added <ul> <li>The JOSS paper was added to the repository.</li> <li>The <a href="https://github.com/mir-am/LightTwinSVM#donations">donation section</a> and its button were added to the README file.</li> <li>
A. Mir
core   +1 more source

MEOX1 Coordinates Autocrine‐Paracrine Programs via SPHK1/S1P to Promote Lymph Node Metastasis in Ovarian Cancer

Advanced Science, EarlyView.
In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li, Xiuling Zhi, Qianhan Lin, Yating Sun, Yihua Sun, Zulimire Abudousalamu, Mengyang Xue, Chang Zheng, Xiaotian Li, Liangqing Yao, Mo Chen   +10 more
wiley   +1 more source

Slowing Down Water: Enhanced and Cation‐responsive MRI Contrast

Angewandte Chemie, EarlyView.
The controlled modification of mesoporous silica nanoparticle side walls with kosmotropic motifs supports an ability to reduce water diffusive mobility and dramatically increase MRI contrast to levels unprecedented for highly kinetically stable Gd‐DOTA configurations (both q = 1 and q = 0).
Connor M. Ellis, James P. Smith, Matthew F. Allen, Ferenc E. Mózes, Stephen Faulkner, Jason J. Davis   +5 more
wiley   +2 more sources