Results 91 to 100 of about 4,640 (185)

The Role of miR-590-3p in Regulating Human Epithelial Ovarian Cancer Development [PDF]

, 2019
Epithelial ovarian cancer (EOC) has the highest mortality rate among all gynecological malignancies. Early detection and intervention remain key to patient prognosis fueling the search for reliable biomarkers. MicroRNAs (miRNAs) are small non-coding RNAs
Salem, Mohamed
core  

Exosomal CCT6A Secreted by Cancer‐Associated Fibroblasts Interacts with β‐Catenin to Enhance Chemoresistance and Tumorigenesis in Gastric Cancer

Advanced Science, EarlyView.
Here, it is revealed that CAF‐secreted exosomal CCT6A enhances stemness, chemoresistance, and glycolysis in GC via the β‐catenin/c‐Myc/DDIT4‐TXNIP axis. Furthermore, CCT6P1, a pseudogene of CCT6A, is identified as upregulating CCT6A by competitively binding miR‐922, while c‐Myc transcriptionally activates both CCT6P1 and CCT6A.
Hui Sun, Tianqi Zhang, Xiaoyan Zhang, Yingxue Liu, Xu Wang, Xin Wang, Cong Tan, Shujuan Ni, Weiwei Weng, Meng Zhang, Lei Wang, Dan Huang, Xiaoyu Wang, Wenfeng Wang, Weiqi Sheng, Mi‐die Xu   +15 more
wiley   +1 more source

Synergy between Defects and Lattice Distortion Drives Self‐Powered Elastico‐Near‐Infrared Mechanoluminescence in Cr3+‐Doped Spinel Oxides

Advanced Science, EarlyView.
This work demonstrates crystal lattice tailoring and defect modulation to engineer a Cr3+‐activated cubic spinel oxide, where strategic introduction of Cr3+ into octahedral Al3+/Li+ sites drives efficient NIR‐ML through a non‐trap‐based mechanism. Abstract Elastico‐mechanoluminescence (ML) enables unique force‐to‐light transduction for applications in ...
Yao Xiao, Kang Chen, Mingzi Sun, Puxian Xiong, Bolong Huang, Yongsheng Sun, Dongdan Chen, Jiulin Gan, Zhongmin Yang   +8 more
wiley   +1 more source

Serum and thyroid tissue level of let-7b and their correlation with TRAb in Graves’ disease

Journal of Translational Medicine, 2018
Background Abnormal microRNAs (miRNAs) were reported to be involved in the mechanism of Graves’ disease (GD). Dysregulated miRNAs may be overlapping in different cells and can be secreted to circulation.
Xinxin Chen, Fengjiao Huang, Yicheng Qi, Mengxi Zhou, Qinglei Yin, Ying Peng, Yulin Zhou, Guang Ning, Shu Wang   +8 more
doaj   +1 more source

MIR205HG/LEADR Long Noncoding RNA Binds to Primed Proximal Regulatory Regions in Prostate Basal Cells Through a Triplex- and Alu-Mediated Mechanism [PDF]

, 2022
Aside serving as host gene for miR-205, MIR205HG transcribes for a chromatin-associated long noncoding RNA (lncRNA) able to restrain the differentiation of prostate basal cells, thus being reannotated as LEADR (Long Epithelial Alu-interacting ...
Bezzecchi, Eugenia, Dolfini, Diletta, Forte, Barbara, Gandellini, Paolo, Pagani, Giulia, Percio, Stefano, Zaffaroni, Nadia   +6 more
core   +1 more source

Phosphazene Base Mediated (sp3)C–H Functionalization with CO2 and CS2

European Journal of Inorganic Chemistry, Accepted Article.
The activation of weakly acidic (sp³)C–H bonds in substrates such as fluoroform (HCF3), perfluoroethane (HC2F5), and acetonitrile (H3CCN) remains a fundamental challenge in synthetic chemistry. We report that the phosphazene base {(Et2N)3P=N}3P=NtBu (EtP4) enables the selective deprotonation of these molecules when combined with electrophilic small ...
Katharina Wels, Beate Neumann, Jan-Hendrik Lamm, Hans-Georg Stammler, Berthold Hoge   +4 more
wiley   +1 more source

Construction of a Nine-MicroRNA-Based Signature to Predict the Overall Survival of Esophageal Cancer Patients

Frontiers in Genetics, 2021
BackgroundEsophageal cancer (EC) is a common malignant tumor. MicroRNAs (miRNAs) play a key role in the occurrence and metastasis and are closely related to the prognosis of EC.
Xiaobin Zhang, Xiaobin Zhang, Yi He, Haiyong Gu, Zhichao Liu, Bin Li, Yang Yang, Jie Hao, Rong Hua   +8 more
doaj   +1 more source

Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria [PDF]

, 2016
Malaria remains one of the greatest public health challenges worldwide, particularly in sub-Saharan Africa. The clinical outcome of individuals infected with Plasmodium falciparum parasites depends on many factors including host systemic inflammatory ...
A Bhoumik, A Bhoumik, A Montecalvo, A Subtil, AK Bei, AT Argaw, C Barres, C Lamaze, C Lawrie, CJ Hemmer, CJ Murray, D Cifuentes, D Nantakomol, DM Patrick, DM Pegtel, DP Bartel, E Lau, E Macia, E Pongponratn, F Tabet, G Lv, G Meister, G Meister, GD Turner, GL Genrich, H Brown, H Valadi, J Baum, J Lu, J Skog, JD Arroyo, KC Vickers, KE Jackson, KM Schweitzer, KN Couper, L Song, LC Dore, LH Miller, M Bastiani, M Dreux, M Klemba, M Raab, M Trajkovski, M Zhan, MI Lin, MP Alves, MP Perron, N Regev-Rudzki, P Landry, P Pino, P Yin, PM Bauer, PY Mantel, R Jambou, R Martinelli, RM O'Connell, S Cheloufi, S Laurance, SY Chen, T Lopotova, UA Orom, V Boonpucknavig, V Combes, Y Lee, Y Zhang   +64 more
core   +1 more source

Plasma Preparation Strategies for Extracellular Vesicle‐Based Biomarkers in Metastatic Castration‐Resistant Prostate Cancer

Journal of Extracellular Biology, Volume 4, Issue 8, August 2025.
This study investigates the influence of pre‐analytical variables on the detection of EV‐based cancer biomarkers. Pre‐identified EV‐associated biomarkers in metastatic prostate cancer (miR‐375, AR‐v7, and PSMA proteins) were detected and quantified in different plasma fractions collected with different anticoagulants from the same cancer patient ...
Prima Dewi Sinawang, Priyanka Multani, Mehmet O. Ozen, Jodie Wong, Demir Akin, Claire Hanson, Matt Larsen, Enos Ampaw, Matthew T. Rondina, Neal D. Tolley, Liang Wang, Brian T. Cunningham, Manish Kohli, Utkan Demirci   +13 more
wiley   +1 more source

RNA Epigenetics in Cancer: Current Knowledge and Therapeutic Implications

MedComm, Volume 6, Issue 8, August 2025.
RNA epigenetics regulates cancer through RNA modifications, splicing, transport, and translation. Key components include m⁶A writers, splicing factors, RBPs, and nuclear export machinery. Aberrant RNA metabolism drives tumor progression and immune evasion.
Shanhe Huang, Zonglin Li, Weilong Lin, Ruihui Xie, Hai Huang   +4 more
wiley   +1 more source