Results 11 to 20 of about 4,305 (116)

MiR-590-3p regulates proliferation, migration and collagen synthesis of cardiac fibroblast by targeting ZEB1. [PDF]

J Cell Mol Med, 2020
AbstractPrevious studies have implicated the attractive and promising role of miR‐590‐3p to restore the cardiac function following myocardial infarction (MI). However, the molecular mechanisms for how miR‐590‐3p involves in cardiac fibrosis remain largely unexplored. Using human cardiac fibroblasts (HCFs) as the cellular model, luciferase report assay,
Yuan X, Pan J, Wen L, Gong B, Li J, Gao H, Tan W, Liang S, Zhang H, Wang X.   +9 more
europepmc   +4 more sources

Long Noncoding RNA ZFAS1 Promotes Progression of NSCLC via Regulating of miR-590-3p. [PDF]

Cell Transplant, 2020
The incidence and mortality rate of nonsmall cell lung cancer (NSCLC) are continuously increasing. Recently, the important roles of long noncoding ribonucleic acid (lncRNA) zinc finger antisense1 (ZFAS1) in the development of many disease have been proved. However, the roles of ZFAS1 in NSCLC are still not completely understood. Thus, this study aimed
Zhou Y, Si L, Liu Z, Shi Y, Agula B.
europepmc   +5 more sources

miR-590-3p Overexpression Improves the Efficacy of hiPSC-CMs for Myocardial Repair. [PDF]

JACC Basic Transl Sci
Recent evidence demonstrates that low engraftment rates limit the efficacy of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) for cardiac repair after myocardial infarction. In this study, we attempted to overcome this limitation by enhancing the proliferative capacity of transplanted hiPSC-CMs.
Zhang Z, Li X, Zhuang J, Ding Q, Zheng H, Ma T, Meng Q, Gao L.   +7 more
europepmc   +3 more sources

miR-590-3p and Its Downstream Target Genes in HCC Cell Lines. [PDF]

Anal Cell Pathol (Amst), 2019
miRNAs are small non-coding RNA sequences of 18-25 nucleotides. They can regulate different cellular pathways by acting on tumor suppressors, oncogenes, or both. miRNAs are mostly tissue-specific, and their expression varies depending on the cancer or the tissue in which they are found.
Elfar M, Amleh A.
europepmc   +5 more sources

MiR-590-3p promotes proliferation and metastasis of colorectal cancer via Hippo pathway. [PDF]

Oncotarget, 2017
Studies reported that miR-590-3p was involved in human cancer progression. However, its roles of oncogene or anti-oncogene in malignancies still remain elusive. This study was aimed to investigate the effect of miR-590-3p on the cell proliferation and metastasis via Hippo pathway in colorectal cancer (CRC).
Sun ZQ, Shi K, Zhou QB, Zeng XY, Liu J, Yang SX, Wang QS, Li Z, Wang GX, Song JM, Yuan WT, Wang HJ.   +11 more
europepmc   +4 more sources

lncRNA SNHG4 modulates colorectal cancer cell cycle and cell proliferation through regulating miR-590-3p/CDK1 axis. [PDF]

Aging (Albany NY), 2021
Colorectal cancer (CRC) is a prevalent malignancy worldwide. The development of genome sequencing technology has allowed the discovery that epigenetic regulation might play a critical role in CRC tumorigenesis. In the present study, we found that the long noncoding RNA (lncRNA) SNHG4 was dramatically increased in CRC tissue samples and cell lines based
Zhou Z, Tan F, Pei Q, Li C, Zhou Y, Li Y, Pei H.   +6 more
europepmc   +4 more sources

MiR-590-3p suppresses epithelial-mesenchymal transition in intrahepatic cholangiocarcinoma by inhibiting SIP1 expression. [PDF]

Oncotarget, 2017
The functional roles and clinical significances of miR-590-3p in ICC remain unclear. In the current study, we investigated the expression of miR-590-3p in tissues and sera of ICC by real-time quantitative polymerase chain reaction. We found miR-590-3p was significantly down-regulated in the sera and tissues of ICC patients, especially in those patients
Zu C, Liu S, Cao W, Liu Z, Qiang H, Li Y, Cheng C, Ji L, Li J, Li J.   +9 more
europepmc   +5 more sources

Elevated hsa-miR-590-3p expression down-regulates HMGB2 expression and contributes to the severity of IgA nephropathy. [PDF]

J Cell Mol Med, 2019
AbstractPeripheral blood mononuclear cells (PBMCs) play important roles in the pathogenesis of IgA nephropathy (IgAN). Our study aimed to provide a deep understanding of IgAN and focused on the dysregulation of hsa‐miR‐590‐3p and its target gene HMGB2 in PBMCs.
Zhai Y, Qi Y, Long X, Dou Y, Liu D, Cheng G, Xiao J, Liu Z, Zhao Z.   +8 more
europepmc   +4 more sources

UCA1 promotes cell proliferation and invasion of gastric cancer by targeting CREB1 sponging to miR-590-3p. [PDF]

Cancer Med, 2018
AbstractLong noncoding RNAs (lncRNAs) have emerged as regulators in a variety of biological processes, including carcinogenesis in human cancer. UCA1 has been reported to be upregulated in gastric cancer (GC); however, the underlying functional roles of UCA1 in GC have not been established.
Gu L, Lu LS, Zhou DL, Liu ZC.
europepmc   +5 more sources

Loss of PPM1F expression predicts tumour recurrence and is negatively regulated by miR-590-3p in gastric cancer. [PDF]

Cell Prolif, 2018
AbstractObjectivesMicroRNAs (miRNAs) as small non‐coding RNA molecules act by negatively regulating their target genes. Recent studies have shown that protein phosphatase Mg2+/Mn2+‐dependent 1F (PPM1F) plays a critical role in cancer metastasis. But, the regulation mechanisms of PPM1F by miRNAs in gastric cancer (GC) remain undefined.MethodsThe ...
Zhang J, Jin M, Chen X, Zhang R, Huang Y, Liu H, Zhu J.   +6 more
europepmc   +5 more sources