Results 61 to 70 of about 4,305 (116)

miR-543 and miR-590-3p regulate human mesenchymal stem cell aging via direct targeting of AIMP3/p18 [PDF]

AGE, 2014
Previously, AIMP3 (aminoacyl-tRNAsynthetase-interacting multifunctional protein-3) was shown to be involved in the macromolecular tRNA synthetase complex or to act as a tumor suppressor. In this study, we report a novel role of AIMP3/p18 in the cellular aging of human mesenchymal stem cells (hMSCs).
Jin Young Lee, Young Sil Ryu, Young Sun Oh, In Sun Hong, Seung-Hee Lee, Sunghoon Kim, Kwang Won Seo, Kyung-Sun Kang, Hyung Sik Kim, Kyung-Rok Yu   +9 more
openaire   +3 more sources

Computational Investigation of Regulatory Region SNPs of Autophagy Gene BECN1 [PDF]

The autophagy process plays a cytoprotective role and ensures the healthy survival of a cell. The role of autophagy has been implicated in various diseases, making it an essential candidate for therapeutic interventions.
Changotra, Harish, Kaur, Sargeet, Vashistt, Jitendraa   +2 more
core   +2 more sources

Oncogenic roles of GOLPH3 in the physiopathology of cancer [PDF]

, 2020
Golgi phosphoprotein 3 (GOLPH3), un effettore del fosfatidilinositolo 4-fosfato [PI (4) P] al Golgi, è necessaria per il mantenimento della struttura del nastro del Golgi, il traffico di vescicole e la glicosilazione del Golgi. GOLPH3 è stato convalidato
Frappaolo A., Giansanti M. G., Karimpour-Ghahnavieh A., Piergentili R., Sechi S.   +4 more
core   +1 more source

Additional file 1 of Functional role and epithelial to mesenchymal transition of the miR-590-3p/MDM2 axis in hepatocellular carcinoma

, 2023
Additional file 1: Figure S1. miR-590-3p directly targets EMT-TF SLUG, ZEB1, and ZEB2 in HCC, as determined by bioinformatics analysis (A) CSmiRTar database analysis showing SLUG, ZEB1 and ZEB2 as miR-590-3p potential target genes. (B) TargetScan analysis showing the sequence alignment between the seed region of miR-50-3p and its downstream target ...
Youssef, Alaa Ibrahem, Khaled, Gehad Mahmoud, Amleh, Asma   +2 more
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Additional file 2 of Functional role and epithelial to mesenchymal transition of the miR-590-3p/MDM2 axis in hepatocellular carcinoma

, 2023
Additional file 2: Figure S2. Sequence alignment between miR-590-3p and N-cadherin but not Vimentin. TargetScan shows that the mesenchymal marker N-cadherin harbours three different binding sites with miR-590-3p in its 3′UTR, while no binding was shown with the other tested mesenchymal marker, Vimentin, supporting the notion that miR-590-3p suppresses ...
Youssef, Alaa Ibrahem, Khaled, Gehad Mahmoud, Amleh, Asma   +2 more
openaire   +1 more source

Development of the Clinical Application of miRNA with Proregenerative Effect on the Heart [PDF]

, 2018
Rationale: Cardiovascular disorders are the first cause of mortality and morbidity worldwide. This is due, at least in part, to the poor regenerative capacity of the heart and the lack of drugs able to foster cardiac regeneration.
Prosdocimo, Giulia
core   +1 more source

Comprehensive molecular characterization of the hippo signaling pathway in cancer [PDF]

, 2018
Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehensive molecular characterization of 19 Hippo core genes in 9,125 tumor samples across 33 cancer types using multidimensional “omic” data from The Cancer ...
Abdel-Rahman, MH, Abeshouse, A, Adebamowo, C, Adebamowo, SN, Agnew, K, Ahn, K, Ajani, JA, Akbani, R, Akeredolu, T, Al-Ahmadie, H, Albert, M, Alexopoulou, I, Ally, A, Alvaro, D, Anderson, ML, Andry, C, Antenucci, A, Anur, P, Appelbaum, EL, Aredes, ND, Armenia, J, Arnaout, A, Asa, SL, Auman, JT, Aymerich, M, Aziz, D, Bailey, M, Balasundaram, M, Balu, S, Barnett, G, Barnholtz-Sloan, JS, Barrett, W, Bartlett, J, Bathe, O, Baudin, E, Baylin, S, Becker, K-F, Beer, D, Behera, M, Behrens, C, Bell, D, Bell, S, Bellair, M, Bennett, J, Benz, C, Berchuck, A, Berger, AC, Bergeron, A, Berkowitz, R, Bernard, B, Beroukhim, R, Beuschlein, F, Bhavana, VH, Bifulco, C, Bigner, D, Birrer, M, Birsoy, K, Bocklage, T, Bodenheimer, T, Bondaruk, J, Bootwalla, MS, Borad, M, Borgia, JA, Bossler, A, Botnariuc, N, Boussioutas, A, Bowen, J, Bowlby, R, Bowman, R, Bradford, C, Bragazzi, MC, Brat, DJ, Breggia, A, Brewer, C, Brimo, F, Broaddus, R, Brooks, D, Broom, BM, Broudy, T, Bryce, AH, Bubley, G, Bueno, R, Burnette, A, Caesar-Johnson, SJ, Calatozzolo, C, Camargo, F, Campo, E, Campos, B, Caraman, I, Cardinale, V, Carey, F, Carey, T, Carlotti, CG, Carlsen, R, Carney, M, Carpino, G, Carroll, PR, Carter, C, Carvalho, AL, Castle, E, Castro, PD, Catto, J, Cebulla, CM, Cernat, M, Chabot, J, Chakravarty, D, Chambwe, N, Chan, JM, Chan, TA, Chandan, V, Chang, K, Chatila, WK, Chemencedji, I, Chen, A, Chen, C, Chen, H, Chen, Z, Cheng, F, Cherniack, AD, Chesla, D, Chevalier, S, Cheville, J, Cho, J, Chuah, E, Chudamani, S, Chung, K, Cibulskis, C, Clipca, A, Colman, H, Cope, L, Copland, JA, Corcoran, N, Cordes, MG, Costello, T, Cottingham, S, Couce, M, Covington, K, Crain, D, Cramer, D, Creaney, J, Creighton, CJ, Creighton, CJ, Cuppini, L, Curley, E, Cuzzubbo, S, Czerniak, B, Danilova, L, Davis, A, de Bruijn, I, de Carvalho, AC, de Krijger, R, De Rienzo, A, De Rose, A, DeFreitas, T, Delman, K, Demchok, JA, Desjardins, L, Devine, K, Deyarmin, B, Dhalla, N, Dhanasekaran, R, Dhankani, V, Dhir, R, Dill, MT, DiMeco, F, Ding, L, Dinh, H, Dinkin, M, DiPersio, J, Disaia, P, Doddapaneni, H, Donehower, LA, Doruc, S, Dos Santos, JS, Dottino, PR, Drake, B, Drummond, J, Drwiega, P, Du, D, Dubina, M, Duell, R, Duffy, ER, Eckman, J, Edenfield, WJ, Eijckenboom, W, Elder, JB, Engel, J, Eschbacher, J, Esmaeli, B, Evason, K, Facciolo, F, Fan, C, Fan, H, Fantacone-Campbell, JL, Farnell, M, Farver, C, Fassnacht, M, Fehrenbach, A, Felau, I, Feldman, M, Feltmate, C, Ferguson, ML, Finocchiaro, G, Flotte, T, Fong, KM, Force, S, Forgie, I, Frazer, S, Fregnani, JH, Fronick, CC, Fujimoto, J, Fulop, J, Fulton, LA, Fulton, RS, Gabra, H, Gabriel, SB, Galbraith, J, Gao, GF, Gao, J, Gardner, J, Gastier-Foster, JM, Gaudio, E, Ge, Z, Gehlenborg, N, Gerken, M, Gershenwald, J, Getz, G, Ghossein, R, Giama, N, Gibbs, RA, Gilbert, S, Gillis, A, Gimenez-Roqueplo, A-P, Giné, E, Giordano, T, Girard, N, Giuliante, F, Glenn, P, Glenn, R, Godwin, AK, Godwin, EM, Gonzalez, AMA, Goodman, M, Gopalan, A, Goparaju, C, Gorincioi, G, Govindan, R, Graefen, M, Grazi, G, Grizzle, WE, Gross, BE, Guillermo, AL, Guo, C, Ha, G, Haddad, A, Hagedorn, CH, Hale, W, Han, L, Han, Y, Hanh, PT, Hansen, P, Harr, J, Hartmann, A, Haydu, L, Hayes, DN, Hayward, N, Heath, S, Hegde, AM, Heiman, DI, Heins, ZJ, Henderson, J, Hermes, B, Hernandez, B, Herold-Mende, C, Hersey, P, Hess, J, Hibshoosh, H, Hilty, J, Hinoue, T, Ho, T, Hoadley, KA, Holt, R, Hooke, JA, Hoon, D, Horowitz, N, Houck, J, Hovens, C, Hoyle, AP, Hu, H, Hu, J, Huland, H, Hung, NP, Huntsman, D, Hutter, CM, Iacocca, M, Ittmann, M, Jacobus, L, Jakrot, V, Janssen, K-P, Jefferys, SR, Jeong, KJ, Jimeno, A, Jones, CD, Jones, SJM, Ju, Z, Juhl, H, Jungk, C, Junker, K, Kakavand, H, Kalkanis, S, Kanchi, RS, Kandoth, C, Kang, KJ, Karlan, BY, Kasaian, K, Kasapi, M, Kastl, A, Kebebew, E, Kefford, R, Kelley, RK, Kemp, R, Kendall, S, Kendler, A, Kendrick, M, Khuri, F, Kibel, A, Kim, J, Knijnenburg, T, Knudson, M, Knutson, T, Kocher, J-P, Kohl, B, Kopp, K, Korchina, V, Korkut, A, Korpershoek, E, Korst, R, Kovatich, AJ, Kramer, R, Kucherlapati, MH, Kucherlapati, RS, Kumar, B, Kundra, R, Kvecher, L, Kycler, W, La, K, Lacombe, L, Ladanyi, M, Lai, PH, Laird, PW, Landen, CN, Landrum, L, Lang, J, Larson, C, Latour, M, Lau, K, Lawrence, MS, Lazar, AJ, Le, X, Lechan, R, Lee, D, Lee, JI, Lee, K, Lee, S, Lehman, NL, Leinonen, K, Leraas, KM, Levine, DA, Lewis, L, Ley, T, Li, J, Li, J, Li, W, Liang, H, Liang, H, Lichtenberg, TM, Lin, P, Linehan, WM, Ling, S, Lipp, E, Liptay, MJ, Liu, J, Liu, W, Liu, X, Liu, Y, Logothetis, C, Lohavanichbutr, P, Lolla, L, Long, G, Longatto-Filho, A, Looijenga, L, Lu, Y, Luketich, J, Luna, A, Lyadov, V, Ma, D, Ma, Y, Madan, R, Maglic, D, Maglinte, DT, Magliocca, K, Maithel, S, Mallery, D, Malykh, A, Mandt, R, Manikhas, G, Mann, G, Mannel, R, Mannelli, M, Mardis, ER, Mariamidze, A, Mariani, O, Marino, M, Marks, J, Marra, MA, Martignetti, JA, Martin, J, Mattei, L, Mayo, M, McCall, S, McGraw, M, McKercher, G, McLellan, MD, McLendon, R, McPherson, C, Meier, S, Melamed, J, Meng, S, Meric-Bernstam, F, Merola, R, Mes-Masson, A-M, Metwalli, AR, Meyerson, M, Mieczkowski, PA, Mikkelsen, T, Milhem, M, Miller, CA, Miller, J, Miller, M, Mills, GB, Mills, GB, Mirsaidi, C, Moiseenko, F, Mojumdar, K, Moncrieff, M, Moore, K, Moore, RA, Moran, C, Moreno, D, Morgan, M, Morris, S, Morrison, C, Morton, D, Mose, LE, Moser, C, Moxley, K, Moyer, J, Mungall, AJ, Mungall, K, Mura, S, Mural, RJ, Murawa, D, Muto, M, Muzny, D, Myers, J, Nagorney, D, Nair, P, Naresh, R, Naska, T, Nelson, M, Ng, K-S, Ng, PK-S, Nguyen, P, Nissan, MG, Noble, MS, Noss, A, Noushmehr, H, Ochoa, A, Olabode, O, Olson, JJ, Omberg, L, Oosterhuis, W, Ostrom, QT, Owonikoko, T, O’Brien, D, O’Neill, BP, Pacak, K, Paklina, O, Parfitt, J, Park, J-W, Parker, JS, Pass, H, Patel, T, Paulauskis, J, Peng, X, Pennell, NA, Penny, R, Perin, A, Perou, AH, Perou, CM, Petersen, G, Peterson, L, Peto, M, Phillips, J, Phillips, SM, Phu, BD, Piché, A, Pickens, A, Pihl, T, Pilarski, R, Pinero, EMM, Pinto, PA, Pirtac, M, Pollo, B, Pool, M, Porten, S, Postier, R, Potapova, O, Powers, J, Prados, M, Prince, M, Que, F, Quinn, M, Quintero-Aguilo, M, Rabeno, B, Rai, K, Ramalingam, S, Ramirez, NC, Ramondetta, L, Rao, A, Rassl, DM, Rathmell, WK, Raut, CP, Raymond, D, Reis, RM, Reuter, V, Reynolds, S, Reznik, E, Rice, D, Richards, WG, Rintoul, RC, Rivera, M, Roach, J, Roberts, L, Robertson, AG, Robinson, B, Roggin, K, Roman-Roman, S, Rosenthal, HG, Rozek, L, Rubin, MA, Ryan, M, Saad, F, Sadeghi, S, Saksena, G, Sanchez-Vega, F, Sander, C, Sankarankuty, A, Santibanez, J, Sastre, X, Sauter, G, Saw, R, Scapulatempo-Neto, C, Scarpace, L, Schadendorf, D, Schein, JE, Schiffman, M, Schilero, C, Schlomm, T, Schmidt, HK, Schmidt, LS, Schoenfield, L, Schultz, N, Schumacher, SE, Scolyer, R, Secord, A, Seder, CW, Sekhon, H, Senecal, K, Sepulveda, A, Setdikova, G, Sexton, KC, Shabunin, A, Shannon, K, Sharp, A, Shelley, CS, Shelton, C, Shelton, T, Shen, H, Sheridan, R, Sherman, M, Sheth, M, Shi, Y, Shih, J, Shimmel, K, Shin, DM, Shinbrot, E, Shipman, C, Shmulevich, I, Shriver, CD, Sica, G, Sifri, S, Sigmund, R, Signoretti, S, Silveira, HCS, Simko, J, Simon, R, Simons, JV, Singer, S, Singh, B, Singh, R, Sipahimalani, P, Skelly, T, Sloan, AE, Slotta-Huspenina, J, Smallridge, R, Smith, J, Smith-McCune, K, Smolenski, K, Smyrk, T, Sofia, HJ, Soloway, MG, Somiari, S, Sood, A, Spellman, P, Spillane, A, Stancul, I, Stanton, M, Staugaitis, SM, Steele, R, Stepa, S, Stern, M-H, Stoehr, C, Stoehr, R, Stoop, H, Stretch, J, Stuart, JM, Su, T, Sumer, SO, Sun, Q, Sun, Y, Swanson, P, Swisher, E, Synott, M, Tam, A, Tamakawa, R, Tamboli, P, Tan, D, Tang, Y, Tarnuzzer, R, Taubert, H, Tavobilov, M, Taylor, BS, Tcaciuc, D, Tennstedt, P, Thiessen, N, Thomas, G, Thompson, E, Thompson, J, Thompson, RH, Thompson, T, Thorp, R, Thorsson, V, Tien, NV, Timmers, H, Tirapelli, D, Tischler, A, Torbenson, M, Troncoso, P, Tsang, YH, Tsao, A, Tse, K, Tucker, K, Têtu, B, Unterberg, A, Urba, W, Valdivieso, F, Van Bang, N, Van Den Berg, DJ, van Kessel, KE, Van Meir, EG, Van Tine, B, VandenBerg, S, Veluvolu, U, Vicha, A, Vidal, DO, Vocke, CD, Voet, D, von Deimling, A, Voronina, O, Wach, S, Wakely, P, Waldmann, J, Walker, J, Wan, Y, Wang, J, Wang, J, Wang, L, Wang, M, Wang, T, Wang, Y, Wang, Z, Warnick, R, Weinstein, JN, Weisenberger, DJ, Wentzensen, N, Westervelt, P, Wheeler, DA, Wilkerson, MD, Williams, F, Wilmott, J, Wilson, RK, Wise, L, Wistuba, I, Wiznerowicz, M, Wolf, G, Wolinsky, Y, Wong, CK, Wong, T, Worrell, R, Wu, Y, Wullich, B, Xi, L, Xu, X, Yang, H, Yang, I, Yang, JD, Yang, L, Yau, C, Yena, P, Zach, LA, Zaren, H, Zelinka, T, Zenklusen, JC, Zhang, H, Zhang, H, Zhang, H, Zhang, H, Zhang, J, Zhang, JJ, Zhang, L, Zhang, W, Zhao, F, Zhou, W, Zmuda, E, Zuna, R, Zwarthoff, EC   +746 more
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Analysis of the dynamic co-expression network of heart regeneration in the zebrafish. [PDF]

, 2016
The zebrafish has the capacity to regenerate its heart after severe injury. While the function of a few genes during this process has been studied, we are far from fully understanding how genes interact to coordinate heart regeneration.
Androsova, G., Azuaje, F., Bernardin, F., Crespo, I., de Klein, N., González-Rosa, J.M., Götz, L., Ibberson, M., Jeanty, C., Liechti, R., Mercader, N., Merz, S., Muller, A., Nazarov, P.V., Niclou, S.P., Rodius, S., Vallar, L., Xenarios, I.   +17 more
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FATTORI DI RISCHIO GENETICI NELLA MALATTIA DI ALZHEIMER E NELLA DEMENZA FRONTOTEMPORALE: STUDIO DI ASSOCIAZIONE DI GENI CANDIDATI POSIZIONALI E FUNZIONALI [PDF]

, 2011
Alzheimer\u2019s disease (AD) and Frontotemporal Lobar Degeneration (FTLD) are two neurodegenerative and multifactorial diseases with complex etiology in which several genes involved in inflammation, oxidative damage and neuronal survival have been ...
M.A. DE RIZ
core   +1 more source

Additional file 3 of Functional role and epithelial to mesenchymal transition of the miR-590-3p/MDM2 axis in hepatocellular carcinoma

, 2023
Additional file 3: Figure (S3). MDM2 siRNA effectively silences MDM2 expression at the protein levels. Western blot uncropped full-length blot for A) first biological replicate and B) second biological replicate.
Youssef, Alaa Ibrahem, Khaled, Gehad Mahmoud, Amleh, Asma   +2 more
openaire   +1 more source