Results 81 to 90 of about 4,084 (142)

MiR‐590‐3p Restores Autophagy in Cultured Human Glomerular Endothelial Cells Exposed to High Glucose

The FASEB Journal, 2019
BackgroundAutophagy is an important mechanism for homeostasis. Previous data mining indicated that miR‐590‐3p was involved in diabetes‐induced endothelial dysfunction. The present study was designed to investigate the role of microRNA‐590‐3p (miR‐590‐3p) in the regulation of autophagy in cultured endothelial cells incubated with high glucose ...
Wenjie Liu, Yi Shi
openaire   +2 more sources

Figure S2 from miR-590-3p Promotes Ovarian Cancer Growth and Metastasis via a Novel FOXA2–Versican Pathway [PDF]

, 2023
Mohamed E. Salem, Jacob A. O’Brien, Stefanie Bernaudo, Heba Shawer, Gang Ye, Jelena Brkić, Asma Amleh, Barbara C. Vanderhyden, Basel Refky, Burton B. Yang, Sergey N. Krylov, Chun Peng   +11 more
openalex   +2 more sources

Role of lncRNA TPRG1-AS1 in the development of cervical squamous cell carcinoma and its prognostic value

Discover Oncology
Objective Cervical squamous cell carcinoma (CSCC) has a poor prognosis due to persistent HPV infection. LncRNA TPRG1-AS1 is linked to regulating the development of many cancers, so the regulatory mechanism and prognostic value of TPRG1-AS1 in CSCC were ...
Yang Fan, Lan Ye, Shuyu Wang, Junwei Wang, Ke Wang, Ying Li   +5 more
doaj   +1 more source

Insights on the functional impact of microRNAs present in autism-associated copy number variants. [PDF]

PLoS ONE, 2013
Autism spectrum disorder is a complex neurodevelopmental disorder that appears during the first three years of infancy and lasts throughout a person's life. Recently a large category of genomic structural variants, denoted as copy number variants (CNVs),
Varadarajan Vaishnavi, Mayakannan Manikandan, Basant K Tiwary, Arasambattu Kannan Munirajan   +3 more
doaj   +1 more source

Prenatal Exposure to Lipopolysaccharide or Valproate Leads to Abnormal Accumulation of the NMDA Receptor Agonist D‐Aspartate in the Adolescent Rat Brain

Journal of Neurochemistry, Volume 169, Issue 6, June 2025.
Autism spectrum disorder (ASD) is a neurodevelopmental condition linked to glutamatergic neurotransmission abnormalities. We analyzed by HPLC the cerebral and peripheral profiles of D‐aspartate, D‐serine, and other L‐amino acids involved in NMDA receptor signaling in environmental ASD rat models prenatally exposed to lipopolysaccharide or valproate ...
Anna Di Maio, Isar Yahyavi, Valeria Buzzelli, Zoraide Motta, Fabrizio Ascone, Lorenza Putignani, Alessandro Usiello, Loredano Pollegioni, Viviana Trezza, Francesco Errico   +9 more
wiley   +1 more source

Single‐Nucleus RNA Sequencing and Spatial Transcriptomics for Squamous Cell Carcinoma Arising From Ovarian Mature Teratoma

Cancer Science, Volume 116, Issue 5, Page 1339-1351, May 2025.
Single‐nucleus RNA‐seq identified KLF5 as an upregulated gene in SCC‐MT cells. Spatial transcriptomics showed inhibited EMT in SCC‐MT cells. KLF5 downregulation reduced SCC‐MT cell proliferation and increased apoptosis. ABSTRACT Squamous cell carcinoma arising from mature teratoma (SCC‐MT) is a rare ovarian malignancy.
Kosuke Yoshida, Akira Yokoi, Hironori Suzuki, Satoshi Tamauchi, Masami Kitagawa, Eri Inami, Jun Nakayama, Yutaro Mori, Koji Okamoto, Yutaka Suzuki, Hiroshi Yoshida, Tomoyasu Kato, Hiroaki Kajiyama, Yusuke Yamamoto   +13 more
wiley   +1 more source

Mesenchymal Stem Cell‐Derived Exosomes: A Promising Therapeutic Strategy for Age‐Related Diseases

Cell Proliferation, Volume 58, Issue 5, May 2025.
Mechanisms of MSC‐Exos in the treatment of age‐related diseases. A Immunomodulatory and anti‐inflammatory, MSC‐Exos mediate immunomodulatory and anti‐inflammatory effects by regulating the polarisation of T cells and macrophages, promoting an anti‐inflammatory state while inhibiting pro‐inflammatory responses; B Suppression of oxidative stress, MSC ...
Bohua Wei, Mengting Wei, Haonan Huang, Ting Fan, Zhichang Zhang, Xiaoyu Song   +5 more
wiley   +1 more source

Additional file 2 of Functional role and epithelial to mesenchymal transition of the miR-590-3p/MDM2 axis in hepatocellular carcinoma

, 2023
Additional file 2: Figure S2. Sequence alignment between miR-590-3p and N-cadherin but not Vimentin. TargetScan shows that the mesenchymal marker N-cadherin harbours three different binding sites with miR-590-3p in its 3′UTR, while no binding was shown with the other tested mesenchymal marker, Vimentin, supporting the notion that miR-590-3p suppresses ...
Youssef, Alaa Ibrahem, Khaled, Gehad Mahmoud, Amleh, Asma   +2 more
openaire   +1 more source

Aluminum Photosensitizers on Trial: Synthesis, Crystal Structures, Photophysical and Photobiological Properties of Tris(Dipyrrinato)Aluminum(III) Complexes with Long‐Lived Triplet States

Chemistry – A European Journal, Volume 31, Issue 19, April 1, 2025.
Homoleptic tris(dipyrrinato)aluminum(III) [AL(DIPY)3] complexes are easily prepared, stable, and form long‐lived triplet excited states. Synthetic, structural, theoretical, photophysical, and photobiological studies highlight the potential of aluminum dipyrrin complexes as a broadly applicable class of photosensitizers.
Zoi Melissari, Brendan Twamley, Lígia C. Gomes‐da‐Silva, John E. O'Brien, Fábio A. Schaberle, Christopher J. Kingsbury, René M. Williams, Mathias O. Senge   +7 more
wiley   +1 more source

Additional file 1 of Functional role and epithelial to mesenchymal transition of the miR-590-3p/MDM2 axis in hepatocellular carcinoma

, 2023
Additional file 1: Figure S1. miR-590-3p directly targets EMT-TF SLUG, ZEB1, and ZEB2 in HCC, as determined by bioinformatics analysis (A) CSmiRTar database analysis showing SLUG, ZEB1 and ZEB2 as miR-590-3p potential target genes. (B) TargetScan analysis showing the sequence alignment between the seed region of miR-50-3p and its downstream target ...
Youssef, Alaa Ibrahem, Khaled, Gehad Mahmoud, Amleh, Asma   +2 more
openaire   +1 more source