Results 171 to 180 of about 4,830 (194)
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Melatonin‐mediated miR‐526b‐3p and miR‐590‐5p upregulation promotes chondrogenic differentiation of human mesenchymal stem cells

Journal of Pineal Research, 2018
AbstractBone marrow‐derived mesenchymal stem cells (BMSCs), with inherent chondrogenic differentiation potential appear to be ideally suited for therapeutic use in cartilage regeneration. Accumulating evidence has demonstrated that melatonin can promote chondrogenic differentiation in human BMSCs. However, little is known about the mechanism. MicroRNAs
Zizhao Wu, Bo Gao, Chengjie Lian
exaly   +3 more sources

Long noncoding RNA DUXAP8 regulates proliferation and apoptosis of ovarian cancer cells via targeting miR-590-5p

Human Cell, 2020
The aim of this study is to investigate the effect of lncRNA DUXAP8 on proliferation and apoptosis of ovarian cancer cells, and to explore its potential mechanism. DUXAP8 interfering and overexpressing cell lines were constructed and the cell proliferation and apoptosis were tested.
Qingyou Meng   +3 more
openaire   +2 more sources

CircDUS2L (circ_0039908) promotes lung adenocarcinoma progression by upregulating PGAM1 by acting as a miR‐590‐5p molecular sponge

Journal of Biochemical and Molecular Toxicology, 2023
AbstractLung adenocarcinoma (LUAD) is usually found at the metastatic stage. Circular RNA dihydrouridine synthase 2‐like (DUS2L) (circDUS2L) has been discovered to be upregulated in LUAD. Nevertheless, the function of circDUS2L in LUAD has not been verified.
Qing Tian   +6 more
openaire   +2 more sources

lncRNA TUG1 promotes endometrial fibrosis and inflammation by sponging miR-590-5p to regulate Fasl in intrauterine adhesions

International Immunopharmacology, 2020
Intrauterine adhesion (IUA) is one of the most common reproductive system diseases in women worldwide. The role of lncRNAs in multiple diseases has been confirmed, but the role and mechanism of lncRNA taurine upregulated gene 1 (TUG1) in the progression of IUA need to be elucidated further.
Ying, Ai   +5 more
openaire   +2 more sources

Circ_0069718 promotes the progression of breast cancer by up-regulating NFIB through sequestering miR-590-5p.

Mammalian genome : official journal of the International Mammalian Genome Society, 2022
Researches indicate that circular RNAs are dysregulated in breast cancer (BC) and play a critical role in regulating the malignant phenotype of cancer cells. Herein, the goal of this work was to investigate the role and mechanism of circ_0069718 in BC development.
Yongsheng, Zhao   +2 more
openaire   +1 more source

Inhibitory Effect of Hsa‐miR‐590‐5p on Cardiosphere‐derived Stem Cells Differentiation Through Downregulation of TGFB Signaling

Journal of Cellular Biochemistry, 2014
ABSTRACTThe cardiac cells generation via stem cells differentiation is a promising approach to restore the myocardial infarction. Promoted by our primary bioinformatics analysis as well as some previously published data on potential role of hsa‐miR‐590‐3p in cardiogenesis, we have tried to decipher the role of miR‐590‐5p during the course of ...
Samaneh, Ekhteraei-Tousi   +5 more
openaire   +2 more sources

[Roles of miR-590-5p and miR-590-3p in the development of hepatocellular carcinoma].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2014
To study the effect of the two arms of miR-590, miR-590-5p and miR-590-3p, on hepatoma cell proliferation and their roles in tumor development.We analyzed and verified the expression pattern of miR-590 in liver cancer specimens and cell lines by miRNA microarrays and QPCR.
Hongfei, Yang   +4 more
openaire   +1 more source

[Effects of miR-590-5p on ox-LDL-induced endothelial cells apoptosis and LOX-1 expression].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2014
To investigate the effect of miR-590-5p on the expression of lectin-like oxidized low density lipoprotein receptor 1 (LOX-1) in apoptotic human umbilical vein endothelial cells (HUVECs) induced by ox-LDL, and to explore the role of miR-590-5p in modulating HUVECs apoptosis.HUVECs were exposed to ox-LDL (50 μg/mL) for 0 to 48 h.
Bing, Qin   +3 more
openaire   +1 more source

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