Results 121 to 130 of about 1,463,889 (197)
Advanced Science, EarlyView.Tellurium substitution for phosphorus in violet phosphorus significantly reduces contact resistance, enhancing FET performance under ambient conditions. ABSTRACT Two‐dimensional materials have attracted much attention in various research fields. The phosphorene structures with various allotropes, another type of elemental 2D materials after graphene ...
Zhuorui Wen +12 more
wiley +1 more source
Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target
Advanced Science, EarlyView.Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen +12 more
wiley +1 more source
Advanced Science, EarlyView.Pathological tissue rigidity mechanoprimes microglia by enhancing actin cytoskeleton–nucleus coupling and chromatin opening at rigidity‐responsive cis‐regulatory elements (mechanoCREs). Subsequent NF‐κB/p65 signaling converges on this permissive regulatory state to amplify inflammatory gene expression and microglial activation.
Yu Xuan Meng +15 more
wiley +1 more source
, 2017 (A, B) Cell morphology of OC cells transfected with either miR-532/miR-3064 mimics (A) or miR-532/miR-3064 inhibitors (B); (C, D) Representative images of invaded ES-2 (C) and SKOV-3 (D) cells transfected as indicated; (E, F) Cell counting kit-8 assay (E)
Ai-Hua Wang (3836656) +4 more
core +1 more source
Advanced Science, EarlyView.Permanent oxidative dipole (POD) engineering overcomes the electronic uniformity of quinoline‐linked COFs. By enhancing the dipole moment to 2.08 D and lowering exciton binding energy to 20.3 meV, it constructs a robust built‐in electric field and spatially decoupled redox centers. This bypasses inherent kinetic bottlenecks, achieving a 4569 µmol g−1 h−
Yong‐Quan Wu +2 more
wiley +1 more source
Qu\u27apporte Mir@bel aux revues scientifiques françaises et leurs éditeurs ? [PDF]
Toutes les revues signalées dans Mir@bel bénéficient : d’un référencement complet qui valorise leur présence numérique en proposant de multiples liens extérieurs d’un réseau de veille collaborative qui assure la qualité des données propagées d’une ...
Mir@bel
core
, 2016 (a) Alignment between XLOC005698 and oar-miR-3955-5p as well as between XLOC000629 and oar-miR-544-5p. (b) The oar-miR-3955-5p miRNA binding sites on XLOC005698. (c)The oar-miR-544-5p miRNA binding sites on XLOC000629.
Tingting Guo (101831) +8 more
core +1 more source
Advanced Science, EarlyView.High‐throughput Differential Dynamic Microscopy measures frequency‐resolved mechanical fingerprints from 3 to 10 μL$\umu{\rm L}$ mucus samples using only a few minutes of operator attention per sample. This automated analysis enables scalable mucus phenotyping for translational research by distinguishing mechanical heterogeneity among donors, disease ...
Feng Ling +18 more
wiley +1 more source
Advanced Science, EarlyView.A HER3‐targeted sonogenetic lipid nanoparticle platform is developed for triple‐negative breast cancer therapy. An AI‐designed miniprotein inhibits HER3 signaling, while TRPV4 and NFAT‐responsive IL‐15 plasmids enable ultrasound‐controlled calcium signaling and cytokine expression. The system induces Ca2+ overload, ROS generation, mitochondrial damage,
Junya Song +6 more
wiley +1 more source
Advanced Science, EarlyView.The Janus nanomotors leverage an “asymmetric structure‐driven functional synergy” strategy to orchestrate spatiotemporally coordinated catalytic functions, in situ self‐amplifying NO generation, and deep tumor penetration, thereby enabling controllable, sustained, and uniform NO generation within the tumor microenvironment.
Chengcheng Li +6 more
wiley +1 more source