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CircCERS6 Suppresses the Development of Epithelial Ovarian Cancer Through Mediating miR-630/RASSF8
Biochemical Genetics, 2022Accumulating evidence have demonstrated that circular RNAs (circRNAs) exert important roles in tumor initiation and progression. Nevertheless, the role and mechanism of circRNA ceramide synthase 6 (circCERS6) in epithelial ovarian cancer (EOC) remain to be clarified.
Xiaoqin, Li +7 more
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Journal of Cellular Physiology, 2021
AbstractAtherosclerosis (AS) is a common disease that seriously threatens human health. So far, the pathogenesis of AS has not been fully understood. This project investigates the effects of circARHGAP12 on AS and its regulatory mechanism. ApoE−/− knockout mice (ApoE) were adopted and reared with a high‐fat diet to construct an AS model. Lentivirus was
Renying Miao +12 more
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AbstractAtherosclerosis (AS) is a common disease that seriously threatens human health. So far, the pathogenesis of AS has not been fully understood. This project investigates the effects of circARHGAP12 on AS and its regulatory mechanism. ApoE−/− knockout mice (ApoE) were adopted and reared with a high‐fat diet to construct an AS model. Lentivirus was
Renying Miao +12 more
openaire +2 more sources
Current Eye Research, 2021
Background: Circular RNAs (circRNAs) have been considered as vital regulators in the progression of human ocular diseases, including diabetic cataract (DC). This report was designed to research the biological role of circRNA phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (circPAG1) in high glucose (HG)-induced lens epithelial ...
Youyi, Yang +3 more
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Background: Circular RNAs (circRNAs) have been considered as vital regulators in the progression of human ocular diseases, including diabetic cataract (DC). This report was designed to research the biological role of circRNA phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (circPAG1) in high glucose (HG)-induced lens epithelial ...
Youyi, Yang +3 more
openaire +2 more sources
E2F1-regulated DROSHA promotes miR-630 biosynthesis in cisplatin-exposed cancer cells
Biochemical and Biophysical Research Communications, 2014DNA damage may regulate microRNA (miRNA) biosynthesis at the levels of miRNA transcription, processing and maturation. Although involvement of E2F1 in the regulation of miRNA gene activation in response to DNA damage has been documented, little is known about the role of E2F1 in miRNA processing.
Ji-Xiang, Cao +5 more
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Current Eye Research, 2023
Dysregulated circular RNAs (circRNAs) is involved in the pathogenesis of age-related cataract (ARC). Here, this study aimed to explore the function and mechanism of circMAP3K4 in ARC.Human lens epithelial cells were exposed to hydrogen peroxide (H2O2) for functional experiments.
Fenghua, Cui +3 more
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Dysregulated circular RNAs (circRNAs) is involved in the pathogenesis of age-related cataract (ARC). Here, this study aimed to explore the function and mechanism of circMAP3K4 in ARC.Human lens epithelial cells were exposed to hydrogen peroxide (H2O2) for functional experiments.
Fenghua, Cui +3 more
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Strahlentherapie und Onkologie, 2022
Circular RNAs (circRNAs) have been reported to be crucial modulatory molecules in the etiology of non-small cell lung cancer (NSCLC). This study aimed to probe the precise role and mechanism of circRNA discs large MAGUK scaffold protein 1 (circDLG1) in the malignant progression of NSCLC.The abundances of circDLG1, miR-630, and centromere protein F ...
Yingying, Chen, Ying, Zhang
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Circular RNAs (circRNAs) have been reported to be crucial modulatory molecules in the etiology of non-small cell lung cancer (NSCLC). This study aimed to probe the precise role and mechanism of circRNA discs large MAGUK scaffold protein 1 (circDLG1) in the malignant progression of NSCLC.The abundances of circDLG1, miR-630, and centromere protein F ...
Yingying, Chen, Ying, Zhang
openaire +2 more sources
Cancer Biomarkers, 2018
BACKGROUND: Increasing studies have identified a series of circulating mircoRNAs (miRNAs) as biomarkers for disease detection due to their stability in the blood. The aim of the present study was to identify specific plasma miRNAs as potential biomarkers for nasopharyngeal carcinoma (NPC) detection.
Xianlu, Zhuo +6 more
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BACKGROUND: Increasing studies have identified a series of circulating mircoRNAs (miRNAs) as biomarkers for disease detection due to their stability in the blood. The aim of the present study was to identify specific plasma miRNAs as potential biomarkers for nasopharyngeal carcinoma (NPC) detection.
Xianlu, Zhuo +6 more
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Journal of Cellular Biochemistry, 2019
AbstractLong noncoding RNA (lncRNA) is a new class of noncoding RNA playing an indispensable role in different diseases by regulating miRNA. Our previous studies have suggested that miR‐630 was decreased in patients with cervical cancer. Recently, studies have shown that lncRNA NOC2L‐4.1 was abnormally expressed in patients with cervical cancer and can
Qingwei Wang +4 more
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AbstractLong noncoding RNA (lncRNA) is a new class of noncoding RNA playing an indispensable role in different diseases by regulating miRNA. Our previous studies have suggested that miR‐630 was decreased in patients with cervical cancer. Recently, studies have shown that lncRNA NOC2L‐4.1 was abnormally expressed in patients with cervical cancer and can
Qingwei Wang +4 more
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Current Eye Research, 2019
Purpose: To investigate the role of miRNAs in regulating oxidative damage during cataract formation.Methods: Microarray analysis and gene expression profiling assay were used to separately evaluate the miRNAs and mRNAs profiles in normal human lens epithelium cell line HLE-B3 treated by H2O2.
Lin, Mei +7 more
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Purpose: To investigate the role of miRNAs in regulating oxidative damage during cataract formation.Methods: Microarray analysis and gene expression profiling assay were used to separately evaluate the miRNAs and mRNAs profiles in normal human lens epithelium cell line HLE-B3 treated by H2O2.
Lin, Mei +7 more
openaire +2 more sources