Results 71 to 80 of about 31,458 (257)

A specific microRNA profile as predictive biomarker for systemic treatment in patients with metastatic colorectal cancer

Cancer Medicine, 2020
Background Palliative systemic therapy is currently standard of care for patients with extensive metastatic colorectal cancer (mCRC). A biomarker predicting chemotherapy benefit which prevents toxicity from ineffective treatment is urgently needed ...
Dennis Poel, Elske C. Gootjes, Lotte Bakkerus, Wim Trypsteen, Henk Dekker, Hans J. van derVliet, Nicole C. T. vanGrieken, Cornelis Verhoef, Tineke E. Buffart, Henk M. W. Verheul   +9 more
doaj   +1 more source

RETRACTED: miR-98-5p inhibits gastric cancer cell stemness and chemoresistance by targeting branched-chain aminotransferases 1

Life Sciences, 2021
Gastric cancer stem cells (GCSCs) have been used as a therapeutic target. This study aims to estimate the role of miR-98-5p (termed miR-98) in the development of GCSCs.The expression of miR-98 in CD44+ GCSCs was verified by RT-PCR. The miR-98 was overexpressed in CD44+ GCSCs by Lentivirus.
Panpan, Zhan, Xiong, Shu, Meng, Chen, Lixin, Sun, Long, Yu, Jun, Liu, Lichao, Sun, Zhihua, Yang, Yuliang, Ran   +8 more
openaire   +2 more sources

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

MiR-98-5p regulates proliferation and metastasis of MCF-7 breast cancer cells by targeting Gab2.

European review for medical and pharmacological sciences, 2019
The article "MiR-98-5p regulates proliferation and metastasis of MCF-7 breast cancer cells by targeting Gab2, by X.-Y. Shi, H. Wang, W. Wang, Y.-H. Gu, published in Eur Rev Med Pharmacol Sci 2019; 23 (7): 2847-2855-DOI: 10.26355/eurrev_201904_17562-PMID: 31002135" has been withdrawn from the authors.
Shi, X.-Y., Wang, H., Wang, W., Gu, Y.-H.   +3 more
openaire   +3 more sources

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

miRNAs-Based Molecular Signature for KRAS Mutated and Wild Type Colorectal Cancer: An Explorative Study

Journal of Immunology Research, 2020
microRNAs (miRNAs) have been proposed as promising molecular biomarkers for diagnosis, prognosis, and responsive therapeutic targets in different types of cancer, including colorectal cancer (CRC).
Elena Milanesi, Maria Dobre, Alina Ioana Bucuroiu, Vlad Herlea, Teodora Ecaterina Manuc, Alessandro Salvi, Giuseppina De Petro, Mircea Manuc, Gabriel Becheanu   +8 more
doaj   +1 more source

Systematic Assessment of Blood-Borne MicroRNAs Highlights Molecular Profiles of Endurance Sport and Carbohydrate Uptake [PDF]

, 2019
Multiple studies endorsed the positive effect of regular exercise on mental and physical health. However, the molecular mechanisms underlying training-induced fitness in combination with personal life-style remain largely unexplored.
Backes, Christina, Fehlmann, Tobias, Hecksteden, Anne, Keller, Andreas, Kern, Fabian, Ludwig, Nicole, Maldener, Esther, Meese, Eckart, Meyer, Tim, Suleymanov, Artur   +9 more
core   +1 more source

MiR-98-5p expression inhibits polarization of macrophages to an M2 phenotype by targeting Trib1 in inflammatory bowel disease

Acta Biochimica Polonica, 2020
Herein, we unfolded miR-98-5p mechanism in inflammatory bowel disease (IBD). IBD mouse model was established. The severity of colitis was assessed daily using the disease activity index (DAI). Murine peritoneal macrophages were stimulated by lipopolysaccharide (LPS).
Yunhua Peng, Qingyuan Wang, Wei Yang, Qiqi Yang, Ynani Pei, Wei Zhang   +5 more
openaire   +3 more sources

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source

Opportunities of Semiconducting Oxide Nanostructures as Advanced Luminescent Materials in Photonics

Advanced Materials, EarlyView.
The review discusses the challenges of wide and ultrawide bandgap semiconducting oxides as a suitable material platform for photonics. They offer great versatility in terms of tuning microstructure, native defects, doping, anisotropy, and micro‐ and nano‐structuring. The review focuses on their light emission, light‐confinement in optical cavities, and
Ana Cremades, Pedro Hidalgo, David Maestre, Ruth Martínez‐Casado, Emilio Nogales, Beatriz Rodríguez, G. Cristian Vásquez, Bianchi Méndez   +7 more
wiley   +1 more source