Results 81 to 90 of about 31,458 (257)

A potential risk factor of essential hypertension in case-control study: MicroRNAs miR-10a-5p

Clinical and Experimental Hypertension, 2020
Background: Essential hypertension is a multifactorial disease with high morbidity. The researches on the influence of genes on the disease are still in its infancy, and the mechanism of gene regulation is not clear.
Yizhe Luo, Xingjie Bao, Shuying Zheng, Tianlun Gu, Shuqi Mao, Shike Liu, Jihan Sun, Mengyi Huang, Lina Zhang   +8 more
doaj   +1 more source

A review on the role of LINC00511 in cancer [PDF]

, 2023
Long Intergenic Non-Protein Coding RNA 511 (LINC00511) is an RNA gene being mostly associated with lung cancer. Further assessments have shown dysregulation of this lncRNA in a variety of cancers.
Ayatollahi, Seyed Abdulmajid, Ghafouri-Fard, Soudeh, Hussen, Bashdar Mahmud, Safarzadeh, Arash, Taheri, Mohammad   +4 more
core   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Summarizing performance for genome scale measurement of miRNA: reference samples and metrics [PDF]

, 2017
Background: The potential utility of microRNA as biomarkers for early detection of cancer and other diseases is being investigated with genome-scale profiling of differentially expressed microRNA.
Pine, P. Scott, Lund, Steven P., Parsons, Jerod R., Vang, Lindsay K., Mahabal, Ashish A., Cinquini, Luca, Kelly, Sean C., Kincaid, Heather, Crichton, Daniel J., Spira, Avrum, Liu, Gang, Gower, Adam C., Pass, Harvey I., Goparaju, Chandra, Dubinett, Steven M., Krysan, Kostyantyn, Stass, Sanford A., Kukuruga, Debra, Van Keuren-Jensen, Kendall, Courtright-Lim, Amanda, Thompson, Karol L., Rosenzweig, Barry A., Sorbara, Lynn, Srivastava, Sudhir, Salit, Marc L.   +24 more
core  

Circulating microRNA profiles predict the severity of COVID-19 in hospitalized patients [PDF]

, 2021
We aimed to examine the circulating microRNA (miRNA) profile of hospitalized COVID-19 patients and evaluate its potential as a source of biomarkers for the management of the disease.
Benítez, Iván D., Carratalá, Amara, Garcia Gasulla, Dario, Gonzalo Calvo, David de, Moncusí Moix, Anna, Pinilla, Lucía   +5 more
core   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

An Update on Circular RNA in Pediatric Cancers [PDF]

, 2023
Circular RNAs (circRNAs) are a class of single-stranded closed noncoding RNA molecules which are formed as a result of reverse splicing of mRNAs. Despite their relative abundance, only recently there appeared an increased interest in the understanding of
Colletti M., Di Giannatale A., Galardi A., Palma A.   +3 more
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Expression of miR-34a-5p and JAG1 in condyloma acuminatum tissues and their correlation with HPV typing and prognosis

Pifu-xingbing zhenliaoxue zazhi, 2023
Objective To investigate the association of miR-34a-5p and JAG1 with type of human papillomavirus (HPV) and the prognosis. Methods Samples of condyloma acuminatum were collected from 101 patients with condyloma acuminatum (all HPV positive) at our ...
Zhaohui ZHANG, Zhenshou LI, Huifang LI, Xiaofang HU, Chunhui GUO, Runjuan YAO, Junxiao LI   +6 more
doaj   +1 more source

Prediction and analysis of microRNAs involved in COVID-19 inflammatory processes associated with the NF-kB and JAK/STAT signaling pathways [PDF]

, 2021
COVID-19 is the cause of a pandemic associated with substantial morbidity and mortality. As yet, there is no available approved drug to eradicate the virus.
Amini-Farsani, Zeinab, Arab, Samaneh, Asgharzade, Samira, Forouzanfar, Fatemeh, Yadollahi, Mitra, Yadollahi-Farsani, Mahtab   +5 more
core   +1 more source