Results 131 to 140 of about 1,588,382 (270)

Breast cancer-secreted miR-122 reprograms glucose metabolism in pre-metastatic niche to promote metastasis

Nature Cell Biology, 2015
Reprogrammed glucose metabolism as a result of increased glycolysis and glucose uptake is a hallmark of cancer. Here we show that cancer cells can suppress glucose uptake by non-tumour cells in the premetastatic niche, by secreting vesicles that carry ...
M. Fong, Weiying Zhou, Liang Liu, A. Alontaga, M. Chandra, Jonathan Ashby, A. Chow, S. O’Connor, Shasha Li, Andrew R. Chin, G. Somlo, M. Palomares, Zhuo Li, Jacob R Tremblay, Akihiro Tsuyada, Guoqiang Sun, M. A. Reid, Xiwei Wu, P. Swiderski, X. Ren, Yanhong Shi, Mei Kong, Wenwan Zhong, Yuan Chen, S. E. Wang   +24 more
semanticscholar   +1 more source

Hippocampal glucocorticoid receptor and microRNA gene expression and serum cortisol concentration in foxes selected for behavior toward humans

Вавиловский журнал генетики и селекции, 2018
In many cases, stress reactivity is one of the important bases of aggressive behavior. It appears as if reduced stress reactivity underlies an abrupt decrease in aggression towards man in domesticated animals.
V. Yu. Ovchinnikov, E. V. Antonov, G. V. Vasilyev, S. G. Shihevich, D. V. Shepeleva, Yu. E. Herbeck   +5 more
doaj   +1 more source

MicroRNA-23a promotes myelination in the central nervous system. [PDF]

, 2013
Demyelinating disorders including leukodystrophies are devastating conditions that are still in need of better understanding, and both oligodendrocyte differentiation and myelin synthesis pathways are potential avenues for developing treatment ...
Fu, Ying-Hui, Heng, Mary Y, Huang, Yong, Lin, Shu-Ting, Ptácek, Louis J, Zhang, Luoying   +5 more
core   +2 more sources

Dietary alterations modulate the microRNA 29/30 and IGF-1/AKT signaling axis in breast Cancer liver metastasis. [PDF]

, 2020
Background: Metastatic cancer is incurable and understanding the molecular underpinnings is crucial to improving survival for our patients. The IGF-1/Akt signaling pathway is often impaired in cancer leading to its progression and metastases.
Camphausen, Kevin, DeAngelis, Tiziana, Saleh, Anthony, Savage, Jason E., Shastri, Anuradha A., Simone, Nicole L.   +5 more
core   +1 more source

miR-638 is a new biomarker for outcome prediction of non-small cell lung cancer patients receiving chemotherapy. [PDF]

, 2015
MicroRNAs (miRNAs), a class of small non-coding RNAs, mediate gene expression by either cleaving target mRNAs or inhibiting their translation. They have key roles in the tumorigenesis of several cancers, including non-small cell lung cancer (NSCLC).
Cao, Yan, Huang, Pu-wen, Lou, Jian-fang, Pan, Shi-yang, Rao, Jian-yu, Shi, Xin-hui, Sun, Rui-hong, Wang, Fang, Wang, Hong, Wang, Peng, Xie, Er-fu, Xu, Jian, Xu, Ting   +12 more
core   +1 more source

MicroRNA-383 located in frequently deleted chromosomal locus 8p22 regulates CD44 in prostate cancer. [PDF]

, 2016
A major genomic alteration in prostate cancer (PCa) is frequent loss of chromosome (chr) 8p with a common region of loss of heterozygosity (LOH) at chr8p22 locus.
Bucay, N, Calin, GA, Calin, GA, Dahiya, R, Deng, G, Hsieh, C, Majid, S, Mitsui, Y, Saini, S, Sekhon, K, Shahryari, V, Tabatabai, ZL, Tanaka, Y, Yamamura, S, Yang, T   +14 more
core   +1 more source

miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis

Nature Cell Biology, 2010
MicroRNAs (miRNAs) are increasingly implicated in regulating the malignant progression of cancer. Here we show that miR-9, which is upregulated in breast cancer cells, directly targets CDH1, the E-cadherin-encoding messenger RNA, leading to increased ...
Li Ma, Jennifer J Young, Harsha K. Prabhala, Elizabeth Pan, P. Mestdagh, D. Muth, J. Teruya-Feldstein, Ferenc Reinhardt, T. Onder, Scott Valastyan, F. Westermann, F. Speleman, J. Vandesompele, R. Weinberg   +13 more
semanticscholar   +1 more source

Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

Nature Communications, 2016
Emerging evidence indicates that osteoclasts direct osteoblastic bone formation. MicroRNAs (miRNAs) have a crucial role in regulating osteoclast and osteoblast function.
Defang Li, Jin Liu, B. Guo, C. Liang, L. Dang, Cheng Lu, Xiaojuan He, H. Y. Cheung, Liang Xu, Changwei Lu, Bing He, Biao Liu, A. Shaikh, Fangfei Li, Luyao Wang, Zhijun Yang, D. Au, S. Peng, Zongkang Zhang, Bao-Ting Zhang, Xiao-hua Pan, A. Qian, P. Shang, Lianbo Xiao, B. Jiang, C. Wong, Jiake Xu, Zhaoxiang Bian, Zicai Liang, D. Guo, Hailong Zhu, W. Tan, Aiping Lu, Ge Zhang   +33 more
semanticscholar   +1 more source

miR-146 and miR-155: Two Key Modulators of Immune Response and Tumor Development

Non-Coding RNA, 2017
MicroRNAs (miRNAs or miRs) are a class of evolutionarily-conserved small, regulatory non-coding RNAs, 19–3 nucleotides in length, that negatively regulate protein coding gene transcripts’ expression.
U. Testa, E. Pelosi, G. Castelli, C. Labbaye   +3 more
semanticscholar   +1 more source

Evitando contenciones. Estrategias farmacológicas en el Hospital de Valme.

Psicosomática y Psiquiatría, 2021
Agustín Sánchez Gayango, Emilio José López Sánchez, Antonio Guzmán del Castillo   +2 more
doaj   +1 more source