Results 1 to 10 of about 3,751 (115)

COVID-Associated Cast-Forming Cholangiopathy: A Commentary on Disease Mechanism, Treatment, and Prognosis

Hepatic Medicine: Evidence and Research, 2023
Yara Sarkis,1 Nasir Saleem,2 Raj Vuppalanchi,2 Mark Gromski2 1Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA; 2Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of ...
Nasir Saleem, Mark Gromski
exaly   +2 more sources

Mixed cholangiopathy with eosinophilic and autoimmune features: a case report [PDF]

Journal of Medical Case Reports
Background Eosinophilic cholangitis and autoimmune cholangiopathy are two rare immune-mediated biliary disorders with distinct demographic, clinical, and histopathological features.
Henry Shen, Isabella Commins, Stuart K. Roberts, Jadon Karp, Ammar Majeed   +4 more
doaj   +2 more sources

COVID-19-Related Cholangiopathy: Histological Findings

Diagnostics
Cholangiopathy has been described in survivors of severe COVID-19, presenting significant clinical parallels to the pre-pandemic condition of secondary sclerosing cholangitis in critically ill patients (SSC-CIP).
, Helma Cotrim, FRANCISCO Guilherme Cancela E Penna   +2 more
exaly   +3 more sources

Challenges in the diagnosis and treatment of genetic cholestasis in adultsKeypoints [PDF]

JHEP Reports
Summary: Disorders of bile formation and bile flow along the intra- and extrahepatic bile ducts are summarised under the term cholestasis. Clinically, conditions resulting in retention of biliary constituents such as bile acids within hepatocytes (termed
Richard J. Thompson, Silvia Vilarinho, Rosa Miquel, Verena Keitel   +3 more
doaj   +2 more sources

The role of miRNAs in the development of cholangiopathies. Part 1

Zdorovʹe Rebenka, 2023
The role of miRNA in the development of cholangiopathies is given in the scientific review. This article discusses the role of miRNA in primary sclerosing cholangitis and primary biliary cho­langitis.
A.E. Abaturov, V.L. Babуch
doaj   +1 more source

A joint transcriptional regulatory network and protein activity inference analysis identifies clinically associated master regulators for biliary atresia

Frontiers in Pediatrics, 2022
Biliary atresia (BA) is a devastating cholangiopathy in neonate. Transcription factors (TFs), a type of master regulators in biological processes and diseases, have been implicated in pathogenesis of BA. However, a global view of TFs and how they link to
Panpan Sun, Panpan Sun, Manhuan Xiao, Manhuan Xiao, Huadong Chen, Zhihai Zhong, Hong Jiang, Xuyang Feng, Xuyang Feng, Zhenhua Luo, Zhenhua Luo   +10 more
doaj   +1 more source

Current Concepts of Biliary Atresia and Matrix Metalloproteinase-7: A Review of Literature

Frontiers in Medicine, 2020
Biliary atresia (BA) is a rare cholangiopathy of infancy in which the bile ducts obliterate, leading to profound cholestasis and liver fibrosis. BA is hypothesized to be caused by a viral insult that leads to over-activation of the immune system ...
Mark Nomden, Leonie Beljaars, Henkjan J. Verkade, Jan B. F. Hulscher, Peter Olinga   +4 more
doaj   +1 more source

The role of miRNAs in the development of cholangiopathies. Part 2

Zdorovʹe Rebenka, 2023
The role of miRNA in the development of cho­langiopathies is considered in the scientific review. This article discusses the role of miRNA in biliary atresia, polycystic liver disease, and cholangiocarcinoma.
A.E. Abaturov, V.L. Babуch
doaj   +2 more sources

Combining ASBT inhibitor and FGF15 treatments enhances therapeutic efficacy against cholangiopathy in female but not male Cyp2c70 KO mice

Journal of Lipid Research, 2023
Therapeutic reduction of hydrophobic bile acids exposure is considered beneficial in cholestasis. The Cyp2c70 KO mice lack hydrophilic muricholic acids and have a human-like hydrophobic bile acid pool resulting in hepatobiliary injury.
Mohammad Nazmul Hasan, Jianglei Chen, David Matye, Huaiwen Wang, Wenyi Luo, Lijie Gu, Yung Dai Clayton, Yanhong Du, Tiangang Li   +8 more
doaj   +1 more source

Reversine attenuates cholestatic ductular reaction in rats

FEBS Open Bio, 2023
Ductular reaction (DR) is usually observed in biliary disorders or various liver disorders, including nonalcoholic fatty liver disease. Few studies have focused on interrupting the DR process in the cholestatic environment.
Di Huang, Lijuan Tang, Tianyang Li, Peilin Li, Zisheng Huang, Jiefeng Weng, Shuai Zhang, Weili Gu, Yu Huang   +8 more
doaj   +1 more source