Results 51 to 60 of about 447,640 (362)
Principles of miRNA/miRNA* function in plant MIRNA processing
Nucleic Acids ResearchAbstract MicroRNAs (miRNAs) are essential regulators of gene expression, defined by their unique biogenesis, which requires the precise excision of the small RNA from an imperfect fold-back precursor. Unlike their animal counterparts, plant miRNA precursors exhibit variations in sizes and shapes.
Santiago Rosatti +6 more
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Brain Organoid and Systems Neuroscience JournalNeural diseases, including neurological and neuropsychiatric disorders, represent a significant and growing public health burden. While the understanding of the genetic origins of these diseases has advanced considerably in recent years, the underlying ...
Silvia Beatini +3 more
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The American Journal of Pathology, 2009 Cancer is the result of a complex multistep process that involves the accumulation of sequential alterations of several genes, including those encoding microRNAs (miRNAs). miRNAs are a class of 17- to 27-nucleotide single-stranded RNA molecules that regulate gene expression posttranscriptionally.
Rosa, Visone, Carlo M, Croce
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Psychological and family factors that influence the occurrence of juvenile delinquency [PDF]
Sinteze, 2019 In this paper, the aggressiveness and delinquent behaviour of adolescents is placed in the context of developmental turbulence that can be temporary. In the case of a young person who violates legal norms, there may be potential for a healthy personality
Slavković Ana R., Slavković Vukan R.
doaj
Post-transcriptional control of miRNA biogenesis
RNA: A publication of the RNA Society, 2018 MicroRNAs (miRNAs) are important regulators of gene expression that bind complementary target mRNAs and repress their expression. Precursor miRNA molecules undergo nuclear and cytoplasmic processing events, carried out by the endoribonucleases DROSHA and
G. Michlewski, J. Cáceres
semanticscholar +1 more source
Journal of Cardiovascular Electrophysiology, 2016 miRNAs Regulate hERGBackgroundThe human ether‐a‐go‐go‐related gene (hERG) is the major molecular component of the rapidly activating delayed rectifier K+ current (Ikr). Impairment of hERG function is believed to be a mechanism causing long‐QT syndromes (LQTS). Growing evidences have shown that microRNAs (miRNAs) are involved in functional modulation of
Jiangfang, Lian +8 more
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The Recent Research Progress of CircRNA in Bladder Cancer
Annals of Urologic Oncology, 2023 Bladder cancer is a major public health problem in the world, and is one of the most common malignant tumors in the genito-urinary system. Due to its high incidence and mortality, it remains a serious threat to human health.
Shuo Liu, Xin-liang Xu
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Effect of exosomal miRNA on cancer biology and clinical applications
Molecular Cancer, 2018 Exosomes, extracellular vesicles with diameters ranging from 30 to 150 nm, are widely present in various body fluids. Recently, microRNAs (miRNAs) have been identified in exosomes, the biogenesis, release, and uptake of which may involve the endosomal ...
Zhenqiang Sun +9 more
semanticscholar +1 more source
Introns of plant pri‐miRNAs enhance miRNA biogenesis
EMBO reports, 2013 Plant MIR genes are independent transcription units that encode long primary miRNA precursors, which usually contain introns. For two miRNA genes, MIR163 and MIR161, we show that introns are crucial for the accumulation of proper levels of mature miRNA. Removal of the intron in both cases led to a drop‐off in the level of mature miRNAs.
Bielewicz, Dawid +7 more
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β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source