Results 121 to 130 of about 360,344 (284)

Identification of Dysregulated Mechanisms and Potential Biomarkers in Ischemic Stroke Onset

International Journal of General Medicine, 2021
Bing Feng,1,* Xinling Meng,2,* Hui Zhou,1,* Liechun Chen,3 Chun Zou,3 Lucong Liang,3 Youshi Meng,3,4 Ning Xu,3,4 Hao Wang,3,4 Donghua Zou3,4 1Department of Neurology, The People’s Hospital of Guiping, Guigang, Guangxi, 537200, People’s ...
Feng B, Meng X, Zhou H, Chen L, Zou C, Liang L, Meng Y, Xu N, Wang H, Zou D   +9 more
doaj  

PDZK1‐ULK1 Axis Triggers Lipophagy to Inhibit Tumor Progression and Sunitinib Resistance in Clear Cell Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reveals that PDZK1 loss impairs ULK1‐mediated lipophagy, driving lipid droplet accumulation and sunitinib resistance in clear cell renal cell carcinoma. PDZK1 inhibits LEF1 nuclear translocation, enhancing ULK1 transcription. Pharmacological ULK1 activation resensitizes resistant tumors to sunitinib.
Xuan Qi, Yu Guo, Yumeng Yang, Haibo Wang, Xiaomei Yang, Ran Song, Qiong Qin, Yan Zhang, Meihan Hu, Haixing Zhou, Duiping Feng, Junqi He   +11 more
wiley   +1 more source

Research Advances and Application Progress on miRNAs in Exosomes Derived From M2 Macrophage for Tissue Injury Repairing

International Journal of Nanomedicine
Zhikang Zhu,1,* Xinge Zhang,1,* Xuran Lin,1 Yuechen Wang,1 Chunmao Han,2,3 Shoujie Wang1,4 1Department of Plastic Surgery, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, Zhejiang University, Yiwu ...
Zhu Z, Zhang X, Lin X, Wang Y, Han C, Wang S   +5 more
doaj  

Identifying Hub Genes and miRNAs Associated with Mesial Temporal Lobe Epilepsy

Experimed
Objective: Mesial temporal lobe epilepsy (MTLE) is a form of focal epilepsy. Recent studies indicate that microRNAs (miRNAs) are involved in the pathogenesis of MTLE.
Ömer Faruk Düzenli, Emrah Yücesan, Simay Bozkurt   +2 more
doaj   +1 more source

Bioabsorbable Endovascular Adhesive Tape (BEAT) for Improving Vascular Regeneration

Advanced Science, EarlyView.
A bioabsorbable endovascular adhesive tape (BEAT) platform based on a hierarchical polyelectrolyte complex is developed to enhance drug delivery in the DCB system. The coating enables rapid transfer to the vessel, provides short‐term mechanical support, and promotes both immediate transfer and long‐term retention of drugs at the lesion site.
Jiarong Wang, Jing Wang, Xinyi Li, Bo Yu, Yiduo Chen, Yirong Guo, Honglin Qian, Meng Hu, Haoyang Liu, Wenhui Liu, Han Xu, Kefeng Ren, M. Cristina L. Martins, Jian Ji   +13 more
wiley   +1 more source

Investigating the Effect of Secretome Secreted from Adult Rat Kidney-Derived Stem Cells on the Expression of miR375, miR494 and Tissue Changes in Glycerol-Induced Acute Kidney Injury

Advanced Biomedical Research
Background: Acute kidney injury (AKI) causes high mortality. Cell therapy has provided acceptable results, but factors such as immune rejection and teratoma formation have limited their use. The purpose of this research is to study the reparative effects
Armita Valizadeh Gorji, Fereshtesadat Fakhredini, Fatemeh Soltanpour, Esrafil Mansouri   +3 more
doaj   +1 more source

MicroRNA‐375‐3p Targets Fatty Acid Synthase and Relish to Regulate Energy Allocation During Pupal Metamorphosis and Starvation

Advanced Science, EarlyView.
During pupal metamorphosis and starvation, elevated 20‐hydroxyecdysone (20E) and suppressed insulin trigger Forkhead box O (FOXO) nuclear translocation, enhancing miR‐375‐3p expression. This downregulates fatty acid synthase (FASN) and Relish, promoting lipid breakdown for energy while prioritizing antioxidant responses over immune functions to support
Peng Chen, Meiqi Cheng, Jianhui Wang, Jing Tang, Xiaoqiao Huang, Yusi Li, Huiling Zhou, Ling Zhang, Yi Dong, Chengjun Li, Bin Li   +10 more
wiley   +1 more source

Logic‐Gated HSV‐TK/GCV Suicide Gene Circuit for Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
The BRAS comprises two modular genetic components driven by distinct tumor‐specific promoters and a failsafe layer with the NOT gate. This multi‐input logic gate circuit enables precise, specific expression of HSV‐TK in breast cancer cells with hardly expression in normal cell and effectively inhibits tumor growth in a triple‐negative breast cancer ...
Shasha Tang, Yuan Fang, Lingli Jin, Dongyang Liu, Yicheng Liu, Ruijia Zheng, Liyun Yong, Xin Wu, Longliang Qiao, Meiyan Wang, Fengfeng Cai   +10 more
wiley   +1 more source

NPM1 Mediates mRNA Sorting into Extracellular Vesicles via Specific RNA Motif Binding and Phase Separation

Advanced Science, EarlyView.
NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang, Gaoge Sun, Xiangzheng Liu, Shuai Zuo, Pengyuan Wang, Boxiao Zhan, Zhi John Lu, Hang Yin, Ying Zhang   +8 more
wiley   +1 more source

Systematic review and meta-analysis of dysregulated miRNAs in patients with severe pneumonia

Türk Biyokimya Dergisi
A meta-analysis was conducted to systematically assess the diagnostic efficacy of miRNAs in severe pneumonia, aiming to identify valuable diagnostic markers for this critical condition.
Wang Chunxia, Ye Xuhui, Xu Jinmei, Li Qiaoke, Sun Mingze, Yi Jianping   +5 more
doaj   +1 more source