Results 111 to 120 of about 287,756 (317)

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

MiRNAs in aortic aneurysm and dissection: a narrative review [PDF]

ExRNA
Background and Objective: Aortic aneurysm and dissection are serious life-threatening cardiovascular emergencies, and their pathogenesis includes vascular inflammation, extracellular matrix remodeling and matrix metalloproteinases, phenotype switch of ...
Huahua Zhang, Xiaoqin Cao, Shuo Ke, Jinhong Xu, Ruixue Shi, Xiaohong Jiang   +5 more
doaj   +1 more source

Introns of plant pri‐miRNAs enhance miRNA biogenesis

The EMBO Reports, 2013
Abstract Plant MIR genes are independent transcription units that encode long primary miRNA precursors, which usually contain introns. For two miRNA genes, MIR163 and MIR161 , we show that ...
Bielewicz, Dawid, Kalak, Malgorzata, Kalyna, Maria, Windels, David, Barta, Andrea, Vazquez, Franck, Szweykowska-Kulinska, Zofia, Jarmolowski, Artur   +7 more
openaire   +4 more sources

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Protein Disulfide Isomerase Disassembles TDP‐43/G3BP1 Condensates and Antagonizes TDP‐43 Pathological Aggregates

Advanced Science, EarlyView.
Cytoplasmic aggregation of TDP‐43 is a common pathological feature in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer's disease with TDP‐43 pathology. This study reports that wild‐type PDI slows down phase separation of TDP‐43 through direct interaction with TDP‐43.
Jia‐Qi Liu, Hao Liu, Yu‐Xuan Sun, Yuying Li, Xiangyi Liu, Li‐Qiang Wang, Zhaofei Yang, Qi Fu, Xiaojiao Xu, Jie Chen, Yingshuang Zhang, Jun Zhou, Weidong Le, Mengchao Cui, Yi Liang   +14 more
wiley   +1 more source

A comparison of the silencing mechanism distribution in old miRNAs (highly conserved miRNAs) and young miRNAs (lowly conserved miRNAs). [PDF]

, 2012
A comparison of the silencing mechanism distribution in old miRNAs (highly conserved miRNAs) and young miRNAs (lowly conserved miRNAs).
Juan Wang (115708), Wei Gao (2085), Bing Shi (126231)   +2 more
core   +1 more source

IL‐7R‐Enriched Extracellular Vesicles From the Thymus Drive Colitis via Promoting Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
Inflammatory bowel disease (IBD) pathogenesis remains unclear. This study reveals that thymus‐originated IL‐7R‐enriched extracellular vesicles exacerbate colitis by promoting neutrophil extracellular traps via a thymus‐gut axis, uncovering an inter‐organ communication mechanism in inflammatory bowel disease pathogenesis.
Yao Liao, Yuheng Liu, Ruibing Yang, Zifeng Zhu, Junwei Wu, Dinghao Li, Jin Su, Yingxin He, Shiqi Luo, Feiyang Cao, Haiyi Deng, Lanmengxi Yang, Ling Zhong, Peiying Peng, Xinyi Wu, Chunmei Cai, Zhen Li, Yujin Wu, Shuofeng Zhu, Jie Wei, Yi Yang, Lifu Wang   +21 more
wiley   +1 more source

Ecological Adaptation Mechanisms Underlying Successful Plant Reproduction

Advanced Science, EarlyView.
During floral induction, various environmental and endogenous signals converge to regulate the florigen protein, which is transported from leaves to the SAM to initiate flowering. Within the SAM, a complex network of receptor kinases and small peptides orchestrates floral development with high spatiotemporal precision.
Hang Zhao, Shenghui Huo, Yue Xing, Shuxin Zhang, Guilin Li, Yihui Liu, Chongyang Jin, Fuguang Li, Xiaoyang Ge   +8 more
wiley   +1 more source

Differential expression of exosomal microRNAs in prefrontal cortices of schizophrenia and bipolar disorder patients [PDF]

, 2013
Exosomes are cellular secretory vesicles containing microRNAs (miRNAs). Once secreted, exosomes are able to attach to recipient cells and release miRNAs potentially modulating the function of the recipient cell.
Andrea Schmitt, Howard Cabral, Vanderburg, Charles, Delalle, Ivana, Ashley R. Winslow (277744), Cagsal-Getkin, Ozge, Vanderburg, Charles R., Joan Costa (277746), Costa Joan, Medina, Juan, Anja Schneider, Cagsal-Getkin Ozge, James A Kozubek, Charles R. Vanderburg (239921), Winslow Ashley R., Kozubek, James A., Winslow, Ashley R., Howard Cabral (277749), Kao, Patricia F., Ozge Cagsal-Getkin, Juan Medina (277745), Meredith G. Banigan (239919), Schmitt Andrea, Juan Medina, Ivana Delalle, Banigan Meredith G., Meredith G Banigan, Schneider Anja, Schneider, Anja, Ashley R Winslow, James A. Kozubek (277743), Vanderburg Charles R., Patricia F. Kao (239917), Anja Schneider (277748), Winslow, Ashley R, Joan Costa, Kozubek James A., Banigan, Meredith G., Costa, Joan, Cabral Howard, Delalle Ivana, Ozge Cagsal-Getkin (277750), Charles R Vanderburg, Andrea Schmitt (277747), Cabral, Howard, Kao Patricia F., Medina Juan, Ivana Delalle (239923), Patricia F Kao, Schmitt, Andrea   +49 more
core   +1 more source

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source