Results 121 to 130 of about 287,756 (317)

Small Extracellular Vesicles‐Derived Circ6718 Unlocks Stromal Remodeling and Serves as a Biomarker in Gastric Cancer

Advanced Science, EarlyView.
sEVs‐circ6718 serves as a promising serum biomarker for gastric cancer early diagnosis and prognosis, promoting malignant transformation in gastric cancer cells and GC‑MSC differentiation into CAFs. sEVs‑circ6718 holds potential as a biomarker for the early diagnosis and prognostic assessment of gastric cancer.
Fan Zhang, Xueyan Zang, Dongli Wang, Rong Li, Hui Qian, Wenrong Xu, Jiajia Jiang, Yongmin Yan   +7 more
wiley   +1 more source

Circulating miR-1246 in the Progression of Chronic Obstructive Pulmonary Disease (COPD) in Patients from the BODE Cohort

International Journal of COPD, 2020
Sara Cazorla-Rivero,1,2 Glorian Mura-Escorche,1,2 Francisca Gonzalvo-Hernández,3 Delia Mayato,1 Elizabeth Córdoba-Lanús,1,2,4,* Ciro Casanova1– 3,* 1Research Unit, Hospital Universitario Nuestra Señora de Candelaria ...
Cazorla-Rivero S, Mura-Escorche G, Gonzalvo-Hernández F, Mayato D, Córdoba-Lanús E, Casanova C   +5 more
doaj  

Comprehensive Prediction of FBN1 Targeting miRNAs: A Systems Biology Approach for Marfan Syndrome [PDF]

Objective: Marfan syndrome (MFS) is a genetic connective tissue disorder primarily caused by mutations in the FBN1 gene. Emerging evidence highlights the regulatory role of microRNAs (miRNAs) in modulating gene expression in MFS, but a systematic ...
Müşerref Duygu Saçar Demirci, Yılmaz Mehmet Demirci, Mehmet Emin Orhan   +2 more
core   +1 more source

Novel miRNAs matched to known miRNAs. [PDF]

, 2012
Novel miRNAs matched to known miRNAs.
Honglin Liu (108352), Ning Wang (108353), Kui Li (48173), Zhonglin Tang (48165), Xinhua Hou (108350), Huiming Ju (108356)   +5 more
core   +1 more source

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

Kaposi's sarcoma herpesvirus microRNAs target caspase 3 and regulate apoptosis [PDF]

, 2011
Kaposi's sarcoma herpesvirus (KSHV) encodes a cluster of twelve micro (mi)RNAs, which are abundantly expressed during both latent and lytic infection.
Contrant, M, Johanna Viiliäinen, Vladimir Benes, Päivi M. Ojala, Voinnet Olivier, Gros, Frédéric, Voinnet, Olivier, Viiliainen, J, Mihaela Zavolan, Benes, Vladimir, Haas Juergen G., Suffert, G, Georg Malterer, Guillaume Suffert, Malterer, G, Frédéric Gros, Gros Frédéric, Ojala, Päivi M, Viiliäinen, Johanna, Suffert, Guillaume, Olivier Voinnet, Hausser Jean, Fender, A, Malterer Georg, Benes, V, Zavolan Mihaela, Ojala Päivi M., Haas, JG, Päivi M Ojala, Hausser, J, Viiliäinen Johanna, Zavolan, Mihaela, Hausser, Jean, Voinnet, O, Suffert Guillaume, Maud Contrant, Pfeffer Sébastien, Haas, Jürgen G., Zavolan, M, Jean Hausser, Tomi Ivacevic, Contrant Maud, Malterer, Georg, Benes Vladimir, Sébastien Pfeffer, Fender Aurélie, Haas, Juergen G, Ivacevic, T, Ojala, PM, Juergen G Haas, Ivacevic, Tomi, Aurélie Fender, Fender, Aurélie, Ojala, Päivi M., Pfeffer, Sébastien, Gros, F, Pfeffer, S, Contrant, Maud, Juergen G. Haas, Ivacevic Tomi, Haas, Juergen G.   +60 more
core   +1 more source

Epithelial TRIM27 Inhibits Intestinal Inflammation in Ulcerative Colitis by the USP7/TRIM27‐IKK Double Negative‐Feedback

Advanced Science, EarlyView.
ABSTRACT The E3 ubiquitin ligase tripartite motif 27 (TRIM27) is a negative regulator of NF‐κB activation and the innate immune response, and TRIM27 deficiency significantly impairs dextran sulfate sodium (DSS)‐induced colitis. The function of TRIM27 in intestinal epithelial cells (IECs), the mechanism by which TRIM27 inhibits the NF‐κB pathway and its
Weimin Xu, Zhebin Hua, Zhujiang Dai, Shasha Zhang, Yihan Jiang, Wensong Ge, YingWei Chen, Zhongchuan Wang, Bing Zhang, Chen‐Ying Liu, Peng Du   +10 more
wiley   +1 more source

MiRNA Bioinformatik als Werkzeug medizinischer Forschung – Etablierung eines Datenbank- und Zielvorhersagesystems zur Bearbeitung von miRNA-bezogenen Fragestellungen [PDF]

, 2011
Mit Beginn der Ära der Hochdurchsatz-Sequenzierung und Transkriptions-messungen ist das Angebot an genetischer Information in den letzten Jahren exponentiell gestiegen.
Hinske, Ludwig Christian Giuseppe
core  

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

Replication Stress and Consequential Instability of the Genome and Epigenome

Molecules, 2019
Cells must faithfully duplicate their DNA in the genome to pass their genetic information to the daughter cells. To maintain genomic stability and integrity, double-strand DNA has to be replicated in a strictly regulated manner, ensuring the accuracy of ...
Pawlos S. Tsegay, Yanhao Lai, Yuan Liu
doaj   +1 more source