Results 121 to 130 of about 365,273 (304)

Research Advances and Application Progress on miRNAs in Exosomes Derived From M2 Macrophage for Tissue Injury Repairing

International Journal of Nanomedicine
Zhikang Zhu,1,* Xinge Zhang,1,* Xuran Lin,1 Yuechen Wang,1 Chunmao Han,2,3 Shoujie Wang1,4 1Department of Plastic Surgery, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, Zhejiang University, Yiwu ...
Zhu Z, Zhang X, Lin X, Wang Y, Han C, Wang S   +5 more
doaj  

Identifying Hub Genes and miRNAs Associated with Mesial Temporal Lobe Epilepsy

Experimed
Objective: Mesial temporal lobe epilepsy (MTLE) is a form of focal epilepsy. Recent studies indicate that microRNAs (miRNAs) are involved in the pathogenesis of MTLE.
Ömer Faruk Düzenli, Emrah Yücesan, Simay Bozkurt   +2 more
doaj   +1 more source

Identification of Dysregulated Mechanisms and Potential Biomarkers in Ischemic Stroke Onset

International Journal of General Medicine, 2021
Bing Feng,1,* Xinling Meng,2,* Hui Zhou,1,* Liechun Chen,3 Chun Zou,3 Lucong Liang,3 Youshi Meng,3,4 Ning Xu,3,4 Hao Wang,3,4 Donghua Zou3,4 1Department of Neurology, The People’s Hospital of Guiping, Guigang, Guangxi, 537200, People’s ...
Feng B, Meng X, Zhou H, Chen L, Zou C, Liang L, Meng Y, Xu N, Wang H, Zou D   +9 more
doaj  

Ecological Adaptation Mechanisms Underlying Successful Plant Reproduction

Advanced Science, EarlyView.
During floral induction, various environmental and endogenous signals converge to regulate the florigen protein, which is transported from leaves to the SAM to initiate flowering. Within the SAM, a complex network of receptor kinases and small peptides orchestrates floral development with high spatiotemporal precision.
Hang Zhao, Shenghui Huo, Yue Xing, Shuxin Zhang, Guilin Li, Yihui Liu, Chongyang Jin, Fuguang Li, Xiaoyang Ge   +8 more
wiley   +1 more source

Exploring the potential relevance of microRNAs targeting the ARVC-related gene interaction network to cancer: an in silico testing hypothesis

Journal of Biological Research - Thessaloniki
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is a genetic disorder of the myocardium. Mutations in the PKP2, DSP, DSG2, DSC2, JUP, TMEM43, PLN and DES genes which encode proteins of the cardiac desmosome have been linked to the disease yet, the
Athanasios Balaskas, Argyris Dallis, Sotirios G Zarogiannis, Chrissi Hatzoglou, Konstantinos I Gourgoulianis, Erasmia Rouka   +5 more
doaj   +1 more source

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Investigating the Effect of Secretome Secreted from Adult Rat Kidney-Derived Stem Cells on the Expression of miR375, miR494 and Tissue Changes in Glycerol-Induced Acute Kidney Injury

Advanced Biomedical Research
Background: Acute kidney injury (AKI) causes high mortality. Cell therapy has provided acceptable results, but factors such as immune rejection and teratoma formation have limited their use. The purpose of this research is to study the reparative effects
Armita Valizadeh Gorji, Fereshtesadat Fakhredini, Fatemeh Soltanpour, Esrafil Mansouri   +3 more
doaj   +1 more source

Small Extracellular Vesicles‐Derived Circ6718 Unlocks Stromal Remodeling and Serves as a Biomarker in Gastric Cancer

Advanced Science, EarlyView.
sEVs‐circ6718 serves as a promising serum biomarker for gastric cancer early diagnosis and prognosis, promoting malignant transformation in gastric cancer cells and GC‑MSC differentiation into CAFs. sEVs‑circ6718 holds potential as a biomarker for the early diagnosis and prognostic assessment of gastric cancer.
Fan Zhang, Xueyan Zang, Dongli Wang, Rong Li, Hui Qian, Wenrong Xu, Jiajia Jiang, Yongmin Yan   +7 more
wiley   +1 more source

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

Systematic review and meta-analysis of dysregulated miRNAs in patients with severe pneumonia

Türk Biyokimya Dergisi
A meta-analysis was conducted to systematically assess the diagnostic efficacy of miRNAs in severe pneumonia, aiming to identify valuable diagnostic markers for this critical condition.
Wang Chunxia, Ye Xuhui, Xu Jinmei, Li Qiaoke, Sun Mingze, Yi Jianping   +5 more
doaj   +1 more source