Results 11 to 20 of about 24,831 (136)

The cooperative regulation of miR-221 by APE1 and AUF1 impacts p27^Kip1 defining a miR signature relevant for cervical cancer. [PDF]

FEBS Open Bio
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Malfatti MC, Gualandi N, Tell G, Antoniali G.   +3 more
europepmc   +2 more sources

Potential therapeutic approaches of microRNAs for COVID-19: Challenges and opportunities

Journal of Oral Biology and Craniofacial Research, 2021
The coronavirus disease 2019 (COVID-19) emerges as current outbreak cause by Novel Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2). This infection affects respiratory system and provides uncontrolled systemic inflammatory response as ...
Alieh Farshbaf, Nooshin Mohtasham, Reza Zare, Farnaz Mohajertehran, Seyed Abdolrahim Rezaee   +4 more
doaj   +1 more source

Differential expression of miR-1297, miR-3191-5p, miR-4435, and miR-4465 in malignant and benign breast tumors [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): MicroRNAs (miRs) are a class of small non-coding RNAs which are associated with tumor growth and progression. In the present study, we assessed the expression of selected miRs in malignant, benign, and adjacent normal breast tissues ...
Abbas Mosapour, Fatemeh Soghra Karami Tehrani, Morteza Atri   +2 more
doaj   +1 more source

Analysis of Harmonic Distortion Reduction through Modular Multi-Level Inverter using Nearest Level Modulation (NLM) Control Strategy

Sukkur IBA Journal of Emerging Technologies, 2021
The research paper presents the control strategy to reduce THD (Total Harmonic Distortions) losses by the implementation of the Nearest Level Modulation control technique in a Modular Multilevel Converter. Modular Multilevel Converter is found one of the
engr Baqir Ali Shah, Mazhar Hussain Baloch, Dr. Amir Mehmood Soomro, Engr Shafqat Hussain Memon, Dr. Dur Muhammad Soomro   +4 more
doaj   +1 more source

Retro-miRs: novel and functional miRNAs originating from mRNA retrotransposition

Mobile DNA, 2023
Background Reverse-transcribed gene copies (retrocopies) have emerged as major sources of evolutionary novelty. MicroRNAs (miRNAs) are small and highly conserved RNA molecules that serve as key post-transcriptional regulators of gene expression.
Rafael L. V. Mercuri, Helena B. Conceição, Gabriela D. A. Guardia, Gabriel Goldstein, Maria D. Vibranovski, Ludwig C. Hinske, Pedro A. F. Galante   +6 more
doaj   +1 more source

Green-Mediated Synthesis of NiCo₂O₄ Nanostructures Using Radish White Peel Extract for the Sensitive and Selective Enzyme-Free Detection of Uric Acid

Biosensors, 2023
The ability to measure uric acid (UA) non-enzymatically in human blood has been demonstrated through the use of a simple and efficient electrochemical method.
Abdul Ghaffar Solangi, Aneela Tahira, Baradi Waryani, Abdul Sattar Chang, Tajnees Pirzada, Ayman Nafady, Elmuez A. Dawi, Lama M. A. Saleem, Mohsen Padervand, Abd Al Karim Haj Ismail, Kangle Lv, Brigitte Vigolo, Zafar Hussain Ibupoto   +12 more
doaj   +1 more source

Vitamin D limits inflammation-linked microRNA expression in adipocytes in vitro and in vivo: A new mechanism for the regulation of inflammation by vitamin D

Epigenetics, 2018
Inflammation of adipose tissue is believed to be a contributing factor to many chronic diseases associated with obesity. Vitamin D (VD) is now known to limit this metabolic inflammation by decreasing inflammatory marker expression and leukocyte ...
Esma Karkeni, Lauriane Bonnet, Julie Marcotorchino, Franck Tourniaire, Julien Astier, Jianping Ye, Jean-François Landrier   +6 more
doaj   +1 more source

Sensory input-dependent gain modulation of the optokinetic nystagmus by mid-infrared stimulation in pigeons

eLife, 2023
Neuromodulation serves as a cornerstone for brain sciences and clinical applications. Recent reports suggest that mid-infrared stimulation (MIRS) causes non-thermal modulation of brain functions. Current understanding of its mechanism hampers the routine
Tong Xiao, Kaijie Wu, Peiliang Wang, Yali Ding, Xiao Yang, Chao Chang, Yan Yang   +6 more
doaj   +1 more source

A systematic screen for micro-RNAs regulating the canonical Wnt pathway. [PDF]

PLoS ONE, 2011
MicroRNAs (miRs) and the canonical Wnt pathway are known to be dysregulated in human cancers and play key roles during cancer initiation and progression.
Roman Anton, Sujash S Chatterjee, Julia Simundza, Pamela Cowin, Ramanuj Dasgupta   +4 more
doaj   +1 more source

Major Role for Cellular MicroRNAs, Long Noncoding RNAs (lncRNAs), and the Epstein-Barr Virus-Encoded BART lncRNA during Tumor Growth In Vivo

mBio, 2022
This study assessed the effects of Epstein-Barr virus (EBV) and one form of virally encoded BART long noncoding RNAs (lncRNAs) on cellular expression in epithelial cells grown in vitro and as tumors in vivo determined by high-throughput RNA sequencing of
Rachel Hood Edwards, Nancy Raab-Traub
doaj   +1 more source