Results 1 to 10 of about 25,130 (143)

Visual mislocalization during double-step saccades [PDF]

Frontiers in Systems Neuroscience, 2015
Visual objects presented briefly at the time of saccade onset appear compressed toward the saccade target. Compression strength depends on the presentation of a visual saccade target signal and is strongly reduced during the second saccade of a double ...
Eckart eZimmermann
doaj   +3 more sources

Rapid and inducible mislocalization of endogenous TDP43 in a novel human model of amyotrophic lateral sclerosis [PDF]

eLife
Transactive response DNA binding protein 43 kDa (TDP43) proteinopathy, characterized by the mislocalization and aggregation of TDP43, is a hallmark of several neurodegenerative diseases, including Amyotrophic Lateral Sclerosis (ALS).
Johanna Ganssauge, Sophie Hawkins, Seema Chandramohan Namboori, Szi Kay Leung, Jonathan Mill, Akshay Bhinge   +5 more
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Inflammation Induces TDP-43 Mislocalization and Aggregation. [PDF]

PLoS ONE, 2015
TAR DNA-binding protein 43 (TDP-43) is a major component in aggregates of ubiquitinated proteins in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD).
Ana Sofia Correia, Priyanka Patel, Kallol Dutta, Jean-Pierre Julien   +3 more
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Samp1 Mislocalization in Emery-Dreifuss Muscular Dystrophy [PDF]

Cells, 2018
LMNA linked-Emery-Dreifuss muscular dystrophy (EDMD2) is a rare disease characterized by muscle weakness, muscle wasting, and cardiomyopathy with conduction defects.
Elisabetta Mattioli, Marta Columbaro, Mohammed Hakim Jafferali, Elisa Schena, Einar Hallberg, Giovanna Lattanzi   +5 more
doaj   +4 more sources

Nemo-like kinase disrupts nuclear import and drives TDP43 mislocalization in ALS [PDF]

The Journal of Clinical Investigation
Cytoplasmic transactive response DNA-binding protein 43 (TDP43) mislocalization and aggregation are pathological hallmarks of amyotrophic lateral sclerosis (ALS). However, the initial cellular insults that lead to TDP43 mislocalization remain unclear. In
Michael E. Bekier II, Emile Pinarbasi, Gopinath Krishnan, Jack J. Mesojedec, Madelaine Hurley, Harisankar Harikumar Sheela, Catherine A. Collins, Layla Ghaffari, Martina de Majo, Erik M. Ullian, Mark Koontz, Sarah Coleman, Xingli Li, Elizabeth M.H. Tank, Jacob Waksmacki, Fen-Biao Gao, Sami J. Barmada   +16 more
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The Role of Temporal Information in Perisaccadic Mislocalization. [PDF]

PLoS ONE, 2015
In dynamic environments, it is crucial to accurately consider the timing of information. For instance, during saccades the eyes rotate so fast that even small temporal errors in relating retinal stimulation by flashed stimuli to extra-retinal information
Maria Matziridi, Eli Brenner, Jeroen B J Smeets   +2 more
doaj   +4 more sources

c-Abl Regulates the Pathological Deposition of TDP-43 via Tyrosine 43 Phosphorylation

Cells, 2022
Non-receptor tyrosine kinase, c-Abl plays a role in the pathogenesis of several neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease.
Saebom Lee, Hye Guk Ryu, Sin Ho Kweon, Hyerynn Kim, Hyeonwoo Park, Kyung-Ha Lee, Sang-Min Jang, Chan Hyun Na, Sangjune Kim, Han Seok Ko   +9 more
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Blocking K-Ras Interaction With the Plasma Membrane Is a Tractable Therapeutic Approach to Inhibit Oncogenic K-Ras Activity

Frontiers in Molecular Biosciences, 2021
Ras proteins are membrane-bound small GTPases that promote cell proliferation, differentiation, and apoptosis. Consistent with this key regulatory role, activating mutations of Ras are present in ∼19% of new cancer cases in the United States per year.
Karen M. Henkels, Kristen M. Rehl, Kwang-jin Cho   +2 more
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Potential Therapeutic Role of HDAC Inhibitors in FUS-ALS

Frontiers in Molecular Neuroscience, 2021
Mutations in the FUS gene cause amyotrophic lateral sclerosis (ALS-FUS). However, the exact pathogenic mechanism of mutant fused in sarcoma (FUS) protein is not completely understood.
Clara Tejido, Donya Pakravan, Donya Pakravan, Ludo Van Den Bosch, Ludo Van Den Bosch   +4 more
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The effect of aquaporin-4 mis-localization on Aβ deposition in mice

Neurobiology of Disease, 2023
The reduced clearance of amyloid-β (Aβ) is thought to contribute to the development of the pathology associated with Alzheimer's disease (AD), which is characterized by the deposition of Aβ plaques.
Taylor J. Pedersen, Samantha A. Keil, Warren Han, Marie X. Wang, Jeffrey J. Iliff   +4 more
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