Results 11 to 20 of about 25,182 (194)

Tuning curves vs. population responses, and perceptual consequences of receptive-field remapping

Frontiers in Computational Neuroscience, 2023
Sensory processing is often studied by examining how a given neuron responds to a parameterized set of stimuli (tuning curve) or how a given stimulus evokes responses from a parameterized set of neurons (population response).
Ning Qian, Ning Qian, Michael E. Goldberg, Michael E. Goldberg, Mingsha Zhang   +4 more
doaj   +1 more source

P23H rhodopsin accumulation causes transient disruptions to synaptic protein levels in rod photoreceptors in a model of retinitis pigmentosa

Disease Models & Mechanisms
Samantha L. Thompson, Sophie M. Crowder, Maryam Hekmatara, Emily R. Sechrest, Wen-Tao Deng, Michael A. Robichaux   +5 more
doaj   +2 more sources

Mislocalization of Nucleocytoplasmic Transport Proteins in Human Huntington’s Disease PSC-Derived Striatal Neurons

Frontiers in Cellular Neuroscience, 2021
Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin gene (HTT). Disease progression is characterized by the loss of vulnerable neuronal populations within the striatum.
Jenny Lange, Alison Wood-Kaczmar, Aneesa Ali, Sahar Farag, Rhia Ghosh, Jennifer Parker, Caroline Casey, Yumiko Uno, Akiyoshi Kunugi, Patrizia Ferretti, Ralph Andre, Sarah J. Tabrizi, Sarah J. Tabrizi   +12 more
doaj   +1 more source

Mislocalization after inhibition of saccadic adaptation

Journal of Vision, 2022
Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster).
Heins, Frauke, Lappe, Markus
openaire   +3 more sources

Dbf4-Dependent Kinase (DDK)-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A in Saccharomyces cerevisiae

G3: Genes, Genomes, Genetics, 2020
The evolutionarily conserved centromeric histone H3 variant (Cse4 in budding yeast, CENP-A in humans) is essential for faithful chromosome segregation. Mislocalization of CENP-A to non-centromeric chromatin contributes to chromosomal instability (CIN) in
Jessica R. Eisenstatt, Lars Boeckmann, Wei-Chun Au, Valerie Garcia, Levi Bursch, Josefina Ocampo, Michael Costanzo, Michael Weinreich, Robert A. Sclafani, Anastasia Baryshnikova, Chad L. Myers, Charles Boone, David J. Clark, Richard Baker, Munira A. Basrai   +14 more
doaj   +1 more source

HJURP antagonizes CENP-A mislocalization driven by the H3.3 chaperones HIRA and DAXX. [PDF]

PLoS ONE, 2018
The centromere specific histone H3 variant CENP-A/CENH3 specifies where the kinetochore is formed in most eukaryotes. Despite tight regulation of CENP-A levels in normal cells, overexpression of CENP-A is a feature shared by various types of solid tumors
Jonathan Nye, David Sturgill, Rajbir Athwal, Yamini Dalal   +3 more
doaj   +1 more source

Pro-Inflammatory Cytokines and Antibodies Induce hnRNP A1 Dysfunction in Mouse Primary Cortical Neurons

Brain Sciences, 2021
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system with a significant neurodegenerative component. Dysfunctional RNA-binding proteins (RBPs) are causally linked to neuronal damage and are a feature of MS, including the ...
Muxue Li, Rachel Hamilton, Hannah E. Salapa, Michael C. Levin   +3 more
doaj   +1 more source

Visual mislocalization during saccade sequences [PDF]

Experimental Brain Research, 2014
Visual objects briefly presented around the time of saccadic eye movements are perceived compressed towards the saccade target. Here, we investigated perisaccadic mislocalization with a double-step saccade paradigm, measuring localization of small probe dots briefly flashed at various times around the sequence of the two saccades. At onset of the first
Eckart Zimmermann, Maria Concetta Morrone, BURR, DAVID CHARLES   +2 more
openaire   +3 more sources

Skp, Cullin, F-box (SCF)-Met30 and SCF-Cdc4-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A for Chromosomal Stability in Budding Yeast.

PLoS Genetics, 2020
Restricting the localization of the histone H3 variant CENP-A (Cse4 in yeast, CID in flies) to centromeres is essential for faithful chromosome segregation.
Wei-Chun Au, Tianyi Zhang, Prashant K Mishra, Jessica R Eisenstatt, Robert L Walker, Josefina Ocampo, Anthony Dawson, Jack Warren, Michael Costanzo, Anastasia Baryshnikova, Karin Flick, David J Clark, Paul S Meltzer, Richard E Baker, Chad Myers, Charles Boone, Peter Kaiser, Munira A Basrai   +17 more
doaj   +1 more source

Ciliary Defects in Inherited Retinal Diseases. [PDF]

Adv Genet (Hoboken)
The photoreceptor cilium is a specialized sensory organelle essential for vision. This review systematically summarizes the structural and functional defects of the cilium that lead to inherited retinal diseases (IRDs). It highlights key pathogenic genes, elucidates molecular mechanisms of degeneration, and evaluates emerging therapeutic strategies ...
Guo G, Li L, Zhou J, Ran J.
europepmc   +2 more sources