Results 61 to 70 of about 31,078 (242)

Keratin 76 is required for tight junction function and maintenance of the skin barrier. [PDF]

PLoS Genetics, 2014
Keratins are cytoskeletal intermediate filament proteins that are increasingly being recognised for their diverse cellular functions. Here we report the consequences of germ line inactivation of Keratin 76 (Krt76) in mice.
Tia DiTommaso, Denny L Cottle, Helen B Pearson, Holger Schlüter, Pritinder Kaur, Patrick O Humbert, Ian M Smyth   +6 more
doaj   +1 more source

Mislocalization of peripheral targets during fixation

Vision Research, 2001
To investigate the effect of the visual stimulus configuration on localization when oculomotor performance is excluded, we evaluated the errors made when subjects compare the horizontal location of two sequentially presented peripheral targets while looking at a visual or memorized fixation spot.
Eggert, T, Ditterich, J, Straube, A
openaire   +2 more sources

Ciliary Membrane Lipid Homeostasis in Health and Disease

Advanced Science, EarlyView.
This review systematically delineates the distinct lipid landscapes of ciliary membranes, including the spatial organization of phosphoinositides, cholesterol, and sphingolipids. It elucidates how these lipids orchestrate ciliogenesis, signal transduction, and membrane dynamics in cilia beating, and highlights how their dysregulation drives ...
Zhenzhou Huang, Yuan‐yuan Liu, Hanqi Sun, Peiwei Liu   +3 more
wiley   +1 more source

Mitochondrial mislocalization underlies Abeta42-induced neuronal dysfunction in a Drosophila model of Alzheimer's disease.

PLoS ONE, 2009
The amyloid-beta 42 (Abeta42) is thought to play a central role in the pathogenesis of Alzheimer's disease (AD). However, the molecular mechanisms by which Abeta42 induces neuronal dysfunction and degeneration remain elusive.
Kanae Iijima-Ando, Stephen A Hearn, Christopher Shenton, Anthony Gatt, Lijuan Zhao, Koichi Iijima   +5 more
doaj   +1 more source

Mislocalization and crowding effects.

, 2013
Mean effect sizes (and standard errors) for Experiments 1 and 2. Stimulus insets show the changes to the stimuli. In Experiment 1 participants mislocalized Gabors in the direction of motion by ∼0.34 degrees and experienced crowding for different motion ...
Gerrit W. Maus (351033), David Whitney (25835), Jason Fischer (351034)   +2 more
core   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Tulp1 deficiency causes early-onset retinal degeneration through affecting ciliogenesis and activating ferroptosis in zebrafish

Cell Death and Disease, 2022
Mutations in TUB-like protein 1 (TULP1) are associated with severe early-onset retinal degeneration in humans. However, the pathogenesis remains largely unknown. There are two homologous genes of TULP1 in zebrafish, namely tulp1a and tulp1b.
Danna Jia, Pan Gao, Yuexia Lv, Yuwen Huang, James Reilly, Kui Sun, Yunqiao Han, Hualei Hu, Xiang Chen, Zuxiao Zhang, Pei Li, Jiong Luo, Xinhua Shu, Zhaohui Tang, Fei Liu, Mugen Liu, Xiang Ren   +16 more
doaj   +1 more source

Parkinson's disease:Electrode mislocalization and repositioning

This chapter deals with dilemma's surrounding the management of patients with insufficient benefit ofdeep brain stimulation of the subthalamic nucleus (STN-DBS) presumed to be due to electrode mislocalization.
Koster, B. J.Myriam, Kuijf, Mark L., Esselink, Rianne, de Ronde, Eva M., Vinke, Samen, Praamstra, Peter, Ackermans, Linda   +6 more
core   +1 more source

Mitochondrial Localization of Cx26 Promotes Colorectal Cancer Malignancy and Exposes a Fatal Vulnerability to Drug Targeting

Advanced Science, EarlyView.
Mitochondrial localization of Cx26 emerges as a double‐edged sword in colorectal cancer. PIMT‐mediated methylation of Cx26 promotes its mitochondrial localization and stability. Mitochondrial Cx26 then facilitates ER‐mitochondria communication and Ca2+ signaling, thereby promoting metastatic progression. Bortezomib exploits this malignant adaptation by
Jie Wang, Lu Chen, Jia Qin, Xiaoning Wang, Sunlan Ye, Ning An, Mei Bai, Yan Shen, Xuefeng Wu, Qiang Xu   +9 more
wiley   +1 more source

Neuronal RNA‐binding protein dysfunction in multiple sclerosis cortex

Annals of Clinical and Translational Neurology, 2020
Objective Neurodegeneration is thought to be the primary cause of neurological disability in multiple sclerosis (MS). Dysfunctional RNA‐binding proteins (RBPs) including their mislocalization from nucleus to cytoplasm, stress granule formation, and ...
Hannah E. Salapa, Catherine Hutchinson, Bogdan F. Popescu, Michael C. Levin   +3 more
doaj   +1 more source