Results 91 to 100 of about 210,406 (304)
Escherichia coli with a Tunable Point Mutation Rate for Evolution Experiments
G3: Genes, Genomes, Genetics, 2020 The mutation rate and mutations’ effects on fitness are crucial to evolution. Mutation rates are under selection due to linkage between mutation rate modifiers and mutations’ effects on fitness.
Nicholas A. Sherer, Thomas E. Kuhlman
doaj +1 more source
The properties of Msh2-Msh6 ATP binding mutants suggest a signal amplification mechanism in DNA mismatch repair. [PDF]
, 2018 DNA mismatch repair (MMR) corrects mispaired DNA bases and small insertion/deletion loops generated by DNA replication errors. After binding a mispair, the eukaryotic mispair recognition complex Msh2-Msh6 binds ATP in both of its nucleotide-binding sites,
Graham, William J +2 more
core
Numerical Exploration of Thermal Shock Resistance in MgO–C Refractories
Advanced Engineering Materials, EarlyView.A mesostructure‐resolved numerical framework is developed to evaluate the thermal shock resistance of MgO–C refractories. By modeling interface debonding under rapid temperature changes and introducing a modified thermal shock parameter that accounts for mesocracks, the study shows how graphite content and aggregate size influence thermal shock ...
Jishnu Vinayak Gopi +3 more
wiley +1 more source
ApoE gene therapy: an overview and update [PDF]
, 2005 Atherosclerosis remains the leading cause of death in industrialized societies. Apolipoprotein E (ApoE) is an attractive candidate to treat hypercholesterolemia and coronary heart disease, as it is a circulating protein with pleiotropic ...
Owen, J.S.
core
Tunable axion plasma haloscopes
, 2019 We propose a new strategy to search for dark matter axions using tunable cryogenic plasmas. Unlike current experiments, which repair the mismatch between axion and photon masses by breaking translational invariance (cavity and dielectric haloscopes), a ...
Lawson, Matthew +4 more
core +1 more source
A Lightweight Procedural Layer for Hybrid Experimental–Computational Workflows in Materials Science
Advanced Engineering Materials, EarlyView.We unveil a prototype hybrid‐workflow framework that fuses automatedcomputation with hands‐on experiments. Built atop pyiron, a lightweight, parameterized layer translates procedure descriptions into executable manual steps, syncing instrument settings, human interventions, and data capture in real‐time today.
Steffen Brinckmann +8 more
wiley +1 more source
MISMATCH REPAIR GENES IN COLORECTAL CARCINOMA
Journal of Cancer and Allied Specialties, 2015 -
Asim Qureshi, Imran N Ahmad
doaj +1 more source
Recognition of abasic sites and single base bulges in DNA by a metalloinsertor [PDF]
, 2009 Abasic sites and single base bulges are thermodynamically destabilizing DNA defects that can lead to cancerous transformations if left unrepaired by the cell.
Barton, Jacqueline K. +2 more
core +1 more source
Contribution of MUTYH variants to male breast cancer risk: results from a multicenter study in Italy [PDF]
, 2018 Inherited mutations in BRCA1, and, mainly, BRCA2 genes are associated with increased risk of male breast cancer (MBC). Mutations in PALB2 and CHEK2 genes may also increase MBC risk.
Azzollini, Jacopo +25 more
core +3 more sources
Advanced Engineering Materials, EarlyView.Graphene nanoplatelet (0.1 wt.%) reinforcement significantly enhances the performance of β Ti‐28Nb‐35.4Zr alloy. Grain refinement, reduced water contact angle, and improved surface characteristics promote osteoblast adhesion and complete surface coverage after 7 days.
Khurram Munir +5 more
wiley +1 more source