Results 71 to 80 of about 811,508 (257)

Educational mismatch and the careers of scientists [PDF]

, 2011
Previous research confirms that many employees work in jobs not well matched to their skills and education, resulting in lower pay and job satisfaction.
Keith A. Bender, John S. Heywood, John Heywood, Keith Bender, Bender, Keith A., Heywood, John S., Heywood, John   +6 more
core   +1 more source

Clinical Impact of MGMT Promoter Methylation in IDH‐Mutant Gliomas: Influence of Threshold Selection and Clinical Confounding

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Haihui Jiang, Linxi Cao, Xiaodong Chen, Siqi Tong, Qinghui Zhu, Jun Yang, Song Lin, Yong Cui   +7 more
wiley   +1 more source

Heterogenous mismatch-repair status in colorectal cancer [PDF]

, 2014
Background: Immunohistochemical staining for mismatch repair proteins is efficient and widely used to identify mismatch repair defective tumors. The tumors typically show uniform and widespread loss of MMR protein staining.
Nynke Veurink, Nilbert, Mef, Harbo, Maria, Louise Klarskov, Mef Nilbert, Bojesen, Anders, Holck, Susanne, Joost, Patrick, Rambech, Eva,, Baldetorp, Bo, Rambech, Eva, Joost, Patrick,, Maria Harbo, Bo Baldetorp, Eva Rambech, Patrick Joost, Klarskov, Louise, Lund University., Susanne Holck, Anders Bojesen, Veurink, Nynke, Baldetorp, Bo,, Nilbert, Mef,   +22 more
core   +1 more source

Decreased transcription-coupled nucleotide excision repair capacity is associated with increased p53- and MLH1-independent apoptosis in response to cisplatin

BMC Cancer, 2010
Background One of the most commonly used classes of anti-cancer drugs presently in clinical practice is the platinum-based drugs, including cisplatin.
Smith Jennifer M, Stubbert Lawton J, McKay Bruce C   +2 more
doaj   +1 more source

Individuals With Multijoint Osteoarthritis Demonstrate Larger Longitudinal Declines in Frailty: Data From the Canadian Longitudinal Study on Aging

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to test the hypothesis that multijoint osteoarthritis would modify the relation between time and frailty progression, in which more affected joints would lead to larger declines over six years compared to those without osteoarthritis using data from the Canadian Longitudinal Study on Aging.
Carson Halliwell, Rebecca Moyer, Myles W. O'Brien   +2 more
wiley   +1 more source

The relationship between DNA damage and repair and the occurrence and development of disease

Frontiers in Genetics
DNA damage can lead to the development of diseases such as tumors. To counteract this, organisms have evolved various repair mechanisms targeting different types of damage.
Chongbing Sun, Haimei Li, Fang Xia, Xiaohong Zhang, Xiaoqing Han   +4 more
doaj   +1 more source

Escherichia coli with a Tunable Point Mutation Rate for Evolution Experiments

G3: Genes, Genomes, Genetics, 2020
The mutation rate and mutations’ effects on fitness are crucial to evolution. Mutation rates are under selection due to linkage between mutation rate modifiers and mutations’ effects on fitness.
Nicholas A. Sherer, Thomas E. Kuhlman
doaj   +1 more source

Observer‐Based Adaptive Event‐Triggered Tracking Control for Fuzzy TS Systems With Premise Mismatch

International Journal of Adaptive Control and Signal Processing, EarlyView.
This paper presents an adaptive logistic event‐triggered observer‐based tracking controller for Takagi‐Sugeno fuzzy systems under constrained inputs and network delays. Leveraging a hybrid LMI and Secretary Bird Optimization approach, this strategy significantly minimizes communication overhead and computational burden while ensuring optimal reference ...
Oussama Djadane, Salama Makni, Mourad Kchaou, Ahmed El Hajjaji   +3 more
wiley   +1 more source

Recognition and repair of compound DNA lesions (base damage and mismatch) by human mismatch repair and excision repair systems. [PDF]

, 1997
Nucleotide excision repair and the long-patch mismatch repair systems correct abnormal DNA structures arising from DNA damage and replication errors, respectively.
D R Duckett, Modrich, P, D Mu, M Tursun, A Sancar, Sancar, A, P Modrich, J T Drummond, Duckett, D R, Mu, D, Tursun, M, Drummond, J T   +11 more
core   +1 more source

Revisiting Stability Criteria in Ball‐Milled High‐Entropy Alloys: Do Hume–Rothery and Thermodynamic Rules Equally Apply?

Advanced Engineering Materials, Volume 27, Issue 6, March 2025.
The stability criteria affecting the formation of high‐entropy alloys, particularly focusing in supersaturated solid solutions produced by mechanical alloying, are analyzed. Criteria based on Hume–Rothery rules are distinguished from those derived from thermodynamic relations. The formers are generally applicable to mechanically alloyed samples.
Javier S. Blázquez, Alejandro F. Manchón‐Gordón, Antonio Vidal‐Crespo, Rafael Caballero‐Flores, Jhon J. Ipus, Clara F. Conde   +5 more
wiley   +1 more source