Results 211 to 220 of about 97,339 (261)

Distinct mutational signature and clonal evolution in constitutional mismatch repair deficiency-associated high-grade gliomas. [PDF]

iScience
Li C, Erson-Omay EZ, Koksal Y, Unal E, Kara B, Bilguvar K, Paksoy Y, Durmus NA, Kurtsoy A, Per H, Østergaard JR, Günel M, Çağlayan AO.   +12 more
europepmc   +1 more source

COX-2 regulates IL-17A-producing γδ T cells to drive mismatch repair-deficient colon cancer

Suzuki T, White M, Leach J, Edwards J, Gilroy K, Porter R, Hong Y, Terradas-Terradas M, Hayman H, Mohamed NE, Lannagan T, Mackey J, Ridgway R, Campbell A, Verbandt S, Kirschner K, Tejpar S, Edwards J, Dunne P, Coffelt S, Sansom O.   +20 more
europepmc   +1 more source

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DNA mismatch repair and cancer

Mutation Research - Reviews in Mutation Research, 2001
Five human DNA mismatch repair genes have been identified that, when mutated, cause susceptibility to hereditary nonpolyposis colorectal cancer (HNPCC). Mutational inactivation of both copies of a DNA mismatch repair gene results in a profound repair defect and progressive accumulation of mutations throughout the genome.
Päivi Tuulikki Peltomaki, P Peltomaki
exaly   +3 more sources

Mismatch Repair

Molecular Biology, 2006
Specific repair systems are activated in response to DNA lesions. Mismatch repair protects the genome of prokaryotic and eukaryotic cells from errors arising during replication or induced by mutagenic factors. The mismatch repair system distinguishes between the newly synthesized and pattern DNA strands by the extent of methylation and checks the ...
N. V. Golyasnaya, N. A. Tsvetkova
  +6 more sources

Ageing and the mismatch repair system

Mechanisms of Ageing and Development, 2001
Age-related accumulation of mutations has been extensively documented, and it has been proposed as one of the prominent causes of malignancies in old age. The present review is focused on the particular case of DNA mismatch repair system (MMR), that has drawn increased attention for its possible relevance to malignancy.
A, Ben Yehuda, A, Globerson, S, Krichevsky, H, Bar On, M, Kidron, Y, Friedlander, G, Friedman, D, Ben Yehuda   +7 more
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Mismatch repair in mammalian cells

BioEssays, 1990
AbstractA vital process in maintaining a low genetic error rate is the removal of mismatched bases in DNA. The importance of this process in E. coli is demonstrated by the 100–1000 fold increase in mutation frequency observed in cells deficient in this repair system(1).
L A, Heywood, J F, Burke
openaire   +2 more sources

Cellular Physiology of Mismatch Repair

Current Pharmaceutical Design, 2004
The DNA mismatch repair system maintains genomic stability by correcting DNA sequence errors generated during DNA replication, during genetic exchanges between chromosomes i.e., recombination, and by correcting DNA lesions caused by mutagenic agents such as cis-platinum.
X, Wu, Z, Khalpey, M, Cascalho
openaire   +2 more sources

Mammalian DNA Mismatch Repair

Annual Review of Genetics, 1999
▪ Abstract  DNA mismatch repair (MMR) is one of multiple replication, repair, and recombination processes that are required to maintain genomic stability in prokaryotes and eukaryotes. In the wake of the discoveries that hereditary nonpolyposis colorectal cancer (HNPCC) and other human cancers are associated with mutations in MMR genes, intensive ...
A B, Buermeyer, S M, Deschênes, S M, Baker, R M, Liskay   +3 more
openaire   +2 more sources

DNA mismatch repair and cancer

Gastroenterology, 1995
The genetic basis of cancer involves certain classes of genes, particularly oncogenes, tumor-suppressor genes, and DNA mismatch repair genes. Originally identified in bacteria and yeast, the human homologues of DNA mismatch repair genes have been implicated in the pathogenesis of the hereditary nonpolyposis colorectal cancer syndromes, as well as a ...
D C, Chung, A K, Rustgi
openaire   +2 more sources