Results 211 to 220 of about 97,151 (260)

Human papilloma virus infection and mismatch repair protein expression in sebaceous neoplasms of the genital area. [PDF]

Histopathology
Wiedemeyer K, Al-Shamma Z, Köbel M, Ferreira I, Harms PW, Brenn T.   +5 more
europepmc   +1 more source

Beyond Histology: A Dual-Cohort Genomic Analysis of 2901 Endometrial Carcinomas Reveals Class-Level Mismatch Repair Effects and Refines Molecular Classification. [PDF]

Genes (Basel)
Sertesen Çamöz E, Karabuğa B, Karaçin C, Terzi YK, Yılmaz Çelik Z.   +4 more
europepmc   +1 more source

Neoadjuvant immunotherapy in mismatch-repair-proficient colon cancers. [PDF]

Nature
Tan PB, Verschoor YL, van den Berg JG, Balduzzi S, Kok NFM, Ijsselsteijn ME, Moore K, Jurdi A, Tin A, Kaptein P, van Leerdam ME, Haanen JBAG, Voest EE, de Miranda NFCC, Schumacher TN, Wessels LFA, Chalabi M.   +16 more
europepmc   +1 more source

COX-2 regulates IL-17A-producing γδ T cells to drive mismatch repair-deficient colon cancer

Suzuki T, White M, Leach J, Edwards J, Gilroy K, Porter R, Hong Y, Terradas-Terradas M, Hayman H, Mohamed NE, Lannagan T, Mackey J, Ridgway R, Campbell A, Verbandt S, Kirschner K, Tejpar S, Edwards J, Dunne P, Coffelt S, Sansom O.   +20 more
europepmc   +1 more source

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DNA mismatch repair and cancer

Mutation Research - Reviews in Mutation Research, 2001
Five human DNA mismatch repair genes have been identified that, when mutated, cause susceptibility to hereditary nonpolyposis colorectal cancer (HNPCC). Mutational inactivation of both copies of a DNA mismatch repair gene results in a profound repair defect and progressive accumulation of mutations throughout the genome.
Päivi Peltomaki
exaly   +3 more sources

Mismatch repair and homeologous recombination

DNA Repair, 2016
DNA mismatch repair influences the outcome of recombination events between diverging DNA sequences. Here we discuss how mismatch repair proteins are active in different homologous recombination subpathways and specific reaction steps, resulting in differential modulation of these recombination events, with a focus on the mechanism of heteroduplex ...
Khek-Chian Tham, Roland Kanaar
exaly   +3 more sources

Mismatch Repair

Molecular Biology, 2006
Specific repair systems are activated in response to DNA lesions. Mismatch repair protects the genome of prokaryotic and eukaryotic cells from errors arising during replication or induced by mutagenic factors. The mismatch repair system distinguishes between the newly synthesized and pattern DNA strands by the extent of methylation and checks the ...
N. V. Golyasnaya, N. A. Tsvetkova
  +6 more sources

Ageing and the mismatch repair system

Mechanisms of Ageing and Development, 2001
Age-related accumulation of mutations has been extensively documented, and it has been proposed as one of the prominent causes of malignancies in old age. The present review is focused on the particular case of DNA mismatch repair system (MMR), that has drawn increased attention for its possible relevance to malignancy.
A, Ben Yehuda, A, Globerson, S, Krichevsky, H, Bar On, M, Kidron, Y, Friedlander, G, Friedman, D, Ben Yehuda   +7 more
openaire   +2 more sources

Mismatch repair in mammalian cells

BioEssays, 1990
AbstractA vital process in maintaining a low genetic error rate is the removal of mismatched bases in DNA. The importance of this process in E. coli is demonstrated by the 100–1000 fold increase in mutation frequency observed in cells deficient in this repair system(1).
L A, Heywood, J F, Burke
openaire   +2 more sources