Results 231 to 240 of about 97,151 (260)
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Pharmacology & Therapeutics, 2018
Microsatellite instability (MSI) refers to the hypermutator phenotype secondary to frequent polymorphism in short repetitive DNA sequences and single nucleotide substitution, as consequence of DNA mismatch repair (MMR) deficiency. MSI secondary to germline mutation in DNA MMR proteins is the molecular fingerprint of Lynch syndrome (LS), while ...
Marina, Baretti, Dung T, Le
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Microsatellite instability (MSI) refers to the hypermutator phenotype secondary to frequent polymorphism in short repetitive DNA sequences and single nucleotide substitution, as consequence of DNA mismatch repair (MMR) deficiency. MSI secondary to germline mutation in DNA MMR proteins is the molecular fingerprint of Lynch syndrome (LS), while ...
Marina, Baretti, Dung T, Le
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Eukaryotic mismatch repair: an update
Mutation Research/DNA Repair, 1998The discovery that mutations in mismatch repair genes segregate with hereditary nonpolyposis colon cancer has awakened a great deal of interest in the study of the process of postreplicative mismatch repair. The characterisation of the principal players involved in this important metabolic pathway has been greatly facilitated by the amino acid sequence
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Prokaryotic DNA Mismatch Repair
2006Publisher Summary There are several scientific reviews available that deal with the multitude of molecular processes involved in repairing various DNA lesions. The chapter discusses prokaryotic DNA mismatch repair pathway. Repair of base mismatches in Escherichia coli and related bacteria is performed by two molecular yet overlapping processes: the ...
Joseph, Nimesh +2 more
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DNA mismatch repair and cancer
Current Opinion in Cell Biology, 1998Mutations in DNA mismatch repair (MMR) genes have been associated with hereditary nonpolyposis colorectal cancer. Studies in bacteria, yeast and mammals suggest that the basic components of the MMR system are evolutionarily conserved, but studies in eukaryotes also imply novel functions for MMR proteins.
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Mismatch repair deficiency: The what, how and why it is important
Genes Chromosomes and Cancer, 2022Maria C Olave, Rondell P Graham
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Mismatch repair deficient colorectal cancer in the era of personalized treatment
Nature Reviews Clinical Oncology, 2010Christopher J Lord +2 more
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DNA mismatch repair and adjuvant chemotherapy in sporadic colon cancer
Nature Reviews Clinical Oncology, 2010Frank A Sinicrope, Sinicrope Frank A
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