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Annual Review of Genetics, 1999
▪ Abstract DNA mismatch repair (MMR) is one of multiple replication, repair, and recombination processes that are required to maintain genomic stability in prokaryotes and eukaryotes. In the wake of the discoveries that hereditary nonpolyposis colorectal cancer (HNPCC) and other human cancers are associated with mutations in MMR genes, intensive ...
A B, Buermeyer +3 more
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▪ Abstract DNA mismatch repair (MMR) is one of multiple replication, repair, and recombination processes that are required to maintain genomic stability in prokaryotes and eukaryotes. In the wake of the discoveries that hereditary nonpolyposis colorectal cancer (HNPCC) and other human cancers are associated with mutations in MMR genes, intensive ...
A B, Buermeyer +3 more
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Constitutioneel 'mismatch repair'-deficientiesyndroom
Nederlands Tijdschrift voor Geneeskunde, 2015Constitutional mismatch repair deficiency (CMMRD) syndrome is characterised by a significantly increased risk for developing cancer in childhood. It arises when both parents have a mutation in the same mismatch repair gene and pass it on to their child.
Jongmans, M.C. +5 more
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Prokaryotic DNA Mismatch Repair
2006Publisher Summary There are several scientific reviews available that deal with the multitude of molecular processes involved in repairing various DNA lesions. The chapter discusses prokaryotic DNA mismatch repair pathway. Repair of base mismatches in Escherichia coli and related bacteria is performed by two molecular yet overlapping processes: the ...
Joseph, Nimesh +2 more
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1998
Studies of human mismatch repair were stimulated by the finding that mutations in genes encoding mismatch repair factors underlie the inherited predisposition to colorectal and other cancers in the hereditary non-polyposis colorectal carcinoma (HNPCC) syndrome and occur quite commonly in apparently sporadic tumours.
M. O’Driscoll, O. Humbert, P. Karran
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Studies of human mismatch repair were stimulated by the finding that mutations in genes encoding mismatch repair factors underlie the inherited predisposition to colorectal and other cancers in the hereditary non-polyposis colorectal carcinoma (HNPCC) syndrome and occur quite commonly in apparently sporadic tumours.
M. O’Driscoll, O. Humbert, P. Karran
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1998
An important property of DNA in all living cells is its ability to form an antiparallel double helix that is stabilized by Watson-Crick pairing between complementary bases. This structural concept provides the basis for templatedirected DNA dynamic processes such as replication, repair and recombination.
P. Schär, J. Jiricny
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An important property of DNA in all living cells is its ability to form an antiparallel double helix that is stabilized by Watson-Crick pairing between complementary bases. This structural concept provides the basis for templatedirected DNA dynamic processes such as replication, repair and recombination.
P. Schär, J. Jiricny
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Nature Genetics, 2000
The DNA repair picture in humans becomes more complete with the identification of MLH3, a homologue of MutL and a heterodimeric partner of MLH1.
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The DNA repair picture in humans becomes more complete with the identification of MLH3, a homologue of MutL and a heterodimeric partner of MLH1.
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2010
The genome is subject to multiple forms of stress and damage that can lead to alterations in the integrity of DNA. The cell nucleus possesses several complex, integrated enzyme systems that identify altered DNA and repair it or, in the case of overwhelming damage, trigger cell death, which prevents the passage of a mutation to the next generation of ...
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The genome is subject to multiple forms of stress and damage that can lead to alterations in the integrity of DNA. The cell nucleus possesses several complex, integrated enzyme systems that identify altered DNA and repair it or, in the case of overwhelming damage, trigger cell death, which prevents the passage of a mutation to the next generation of ...
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DNA mismatch repair: MutS structures bound to mismatches
Current Opinion in Structural Biology, 2001When DNA mismatch repair fails, the result is a mutator phenotype, which can lead to cancer in humans. Functional repair is dependent on the recognition of mismatches by a dimeric MutS protein, a homodimer in bacteria but a heterodimer in humans. Recent crystal structures of Thermus aquaticus and Escherichia coli MutS have revealed the structural ...
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DNA mismatch repair and cancer
Mutation Research/Reviews in Mutation Research, 2001Five human DNA mismatch repair genes have been identified that, when mutated, cause susceptibility to hereditary nonpolyposis colorectal cancer (HNPCC). Mutational inactivation of both copies of a DNA mismatch repair gene results in a profound repair defect and progressive accumulation of mutations throughout the genome.
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