Results 41 to 50 of about 811,508 (257)

Immunhistokjemisk påvisning av mismatch repair-proteiner [PDF]

, 2019
Bakgrunn: Immunhistokjemisk farging av vevssnitt kan påvise mismatch repair (MMR)- proteinene MLH1, PMS2, MSH2 og MSH6, som normalt uttrykkes i cellekjernen. Tap av en eller flere av disse kan indikere Lynch syndrom.
Amundlien, Eirin, Wålberg, Lise Eid, Sandberg, Renate   +2 more
core   +1 more source

Intratumoral budding as a potential parameter of tumor progression in mismatch repair-proficient and mismatch repair-deficient colorectal cancer patients

, 2011
In colorectal cancer, tumor budding at the invasive front (peritumoral budding) is an established prognostic parameter and decreased in mismatch repair-deficient tumors.
Patsouris, Efstratios S, Karamitopoulou, Eva, Patsouris, Efstratios S., Zlobec, Inti, Alessandro Lugli, Vlajnic, Tatjana, Peros, George, Luigi M. Terracciano, Terracciano, Luigi M, Inti Zlobec, Giger, Olivier, Eva Karamitopoulou, Tatjana Vlajnic, George Peros, Lugli, Alessandro, Olivier Giger, Efstratios S. Patsouris, Terracciano, Luigi M.   +17 more
core   +1 more source

Bibliometric analysis of immune dysregulation and immunotherapy in mismatch repair-deficient colon cancer

Discover Oncology
Background Mismatch repair deficiency (dMMR) is observed in 12–15% of sporadic colon carcinomas. dMMR tumors have unique genetic characteristics, with mutation rates 10 to 100 times higher than those of tumors with intact mismatch repair functions ...
Xingtao Jin, Hao Wang, Ye Han, Min Yang, Qianqian Ye, Qingming Wang, De Zheng, Zubing Mei   +7 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Fruits, vegetables, and hMLH1 protein-deficient and -proficient colon cancer: The Netherlands cohort study. [PDF]

, 2005
BACKGROUND: Clinical and pathologic differences exist between colon carcinomas deficient and proficient in the mismatch repair protein hMLH1. Animal and in vitro studies suggest that fruits, vegetables, folate, and antioxidants are associated with ...
Brandt, P.A. van den, van Wijhe, G., van Muijen, Goos NP, Goldbohm, R.A., van Wijhe, Gerda, Goldbohm, R Alexandra, Muijen, G.N.P. van, van den Brandt, Piet A, Wijhe, G. van, Wark, Petra A.; id_orcid, Goldbohm, R. Alexandra, Van Muijen, Goos N P, Van Den Brandt, Piet A., Veer, P. van 't, van 't Veer, Pieter, Weijenberg, Matty P., Weijenberg, Matty P, de Goeij, Anton FPM, Wark, P.A., De Goeij, Anton F P M, van Muijen, G.N.P., van 't Veer, P., van den Brandt, P.A., Luchtenborg, M., Goeij, A.F.P.M. de, Goeij, A.F. de, Weijenberg, M.P., Wark, Petra A, Lüchtenborg, Margreet, de Goeij, A.F., de Goeij, A.F.P.M., Van't Veer, Pieter   +31 more
core   +3 more sources

Colonic Adenocarcinoma at Advanced Stage in Adolescence: Report of 2 Cases

Case Reports in Pathology, 2020
Background. Carcinoma of colon is rare in children and adolescents. The staging criteria of the carcinoma is the same as those for adults. However, the pathogenetic background in pediatric cases is different from adults and usually involves mismatch ...
Divya S. Vundamati, Xiuxu Chen, Vivekanand Singh   +2 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Biallelic Mismatch Repair Deficiency in Children and Adolescents: A Review of Published and Unpublished Data from India—Need for an Indian Consortium

Indian Journal of Medical and Paediatric Oncology
Introduction Biallelic mismatch repair deficiency or constitutional mismatch repair deficiency (CMMRD) is a rare and aggressive pediatric cancer predisposition syndrome that occurs as a result of homozygous (biallelic) pathogenic variants in ...
Gazel Sainulabdin, Purva Kanvinde, Ritika Khurana, Sangeeta Mudaliar, Vasudeva Bhat K, Anju Shukla, V. P. Krishnan, Yamini Krishnan   +7 more
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source