Results 21 to 30 of about 811,508 (257)

Escherichia coli frameshift mutation rate depends on the chromosomal context but not on the GATC content near the mutation site. [PDF]

PLoS ONE, 2012
Different studies have suggested that mutation rate varies at different positions in the genome. In this work we analyzed if the chromosomal context and/or the presence of GATC sites can affect the frameshift mutation rate in the Escherichia coli genome.
Mariana A Martina, Elisa M E Correa, Carlos E Argaraña, José L Barra   +3 more
doaj   +1 more source

Mismatch repair deficiency/microsatellite instability-high as a predictor for anti-PD-1/PD-L1 immunotherapy efficacy

Journal of Hematology & Oncology, 2019
Immunotherapies have led to substantial changes in cancer treatment and have been a persistently popular topic in cancer research because they tremendously improve the efficacy of treatment and survival of individuals with various cancer types.
Pengfei Zhao, Li Li, Xiaoyue Jiang, Qin Li   +3 more
doaj   +1 more source

Pms2 suppresses large expansions of the (GAA·TTC)n sequence in neuronal tissues [PDF]

, 2012
Copyright @ 2012 Bourn et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
De Biase, I, Al-Mahdawi, S, De Biase Irene, Al-Mahdawi Sahar, Pinto Ricardo Mouro, Sandi, C, Pook, MA, Pinto, RM, Sahar Al-Mahdawi, Chiranjeevi Sandi, Sandi Chiranjeevi, Sanjay I Bidichandani, Bourn Rebecka L., Bidichandani, S, Irene De Biase, Bourn, RL, Ricardo Mouro Pinto, Pook Mark A., Rebecka L Bourn, Bidichandani Sanjay I., Mark A Pook   +20 more
core   +2 more sources

Blockade of LAG3 enhances responses of tumor-infiltrating T cells in mismatch repair-proficient liver metastases of colorectal cancer

OncoImmunology, 2018
Purpose: Liver metastasis develops in >50% of patients with colorectal cancer (CRC), and is a leading cause of CRC-related mortality. We aimed to identify which inhibitory immune checkpoint pathways can be targeted to enhance functionality of intra ...
Guoying Zhou, Lisanne Noordam, Dave Sprengers, Michail Doukas, Patrick P. C. Boor, Adriaan A. van Beek, Remco Erkens, Shanta Mancham, Dirk Grünhagen, Anand G. Menon, Johan F. Lange, Pim J. W. A. Burger, Alexandra Brandt, Boris Galjart, Cornelis Verhoef, Jaap Kwekkeboom, Marco J. Bruno   +16 more
doaj   +1 more source

Association of clinicopathological features with DNA mismatch repair status among colorectal cancer patients presenting to a Tertiary Care Cancer Hospital

International Journal of Advanced Medical and Health Research, 2022
Background: About 12%–15% of sporadic colorectal cancers (CRCs) display a defect in the DNA mismatch repair (MMR) system resulting in microsatellite instability (MSI).
Gayathri G Nair, Vijayalakshmi Nair, Usha Mary Abraham   +2 more
doaj   +1 more source

Prevalence and prognostic role of mismatch repair gene defect in endometrial cancer patients

Tumor Biology, 2017
The study was to evaluate the prevalence of mismatch repair gene defect among Thai patients with endometrial cancer and its association with clinico-pathological features and survivals.
Siriwan Tangjitgamol, Thannaporn Kittisiam, Sujitra Tanvanich   +2 more
doaj   +1 more source

A rapid, simple DNA mismatch repair substrate construction method

Frontiers in Oncology, 2011
A more flexible and higher yielding in vitro DNA mismatch repair (MMR) substrate construction method, which was developed initially by Wang and Hays, is described for the construction of a nucleotide-based chemical mismatch (G/IU) and a G/T mismatch. Our
Timothy James Kinsella, Timothy James Kinsella, Weinan eDu   +2 more
doaj   +1 more source

A function of thymine DNA glycosylase-initiated DNA repair in maintaining epigenome stability [PDF]

, 2013
The Thymine DNA Glycosylase (TDG) was initially discovered by its ability to excise the deamination products of cytosine and 5-methylcytosine (5-mC), and therefore thought to initiate base excision repair (BER) of the resulting G•U and G•T mismatches.
Jacobs, Angelika L.
core   +1 more source

Unexplained mismatch repair deficiency: Case closed

HGG Advances, 2023
Summary: To identify Lynch syndrome (LS) carriers, DNA mismatch repair (MMR) immunohistochemistry (IHC) is performed on colorectal cancers (CRCs). Upon subsequent LS diagnostics, MMR deficiency (MMRd) sometimes remains unexplained (UMMRd).
Ellis L. Eikenboom, Sarah Moen, Lotte van Leeuwen, Willemina R.R. Geurts-Giele, Carli M.J. Tops, Tjakko J. van Ham, Winand N.M. Dinjens, Hendrikus J. Dubbink, Manon C.W. Spaander, Anja Wagner   +9 more
doaj   +1 more source

The Eukaryotic Mismatch Recognition Complexes Track with the Replisome during DNA Synthesis.

PLoS Genetics, 2015
During replication, mismatch repair proteins recognize and repair mispaired bases that escape the proofreading activity of DNA polymerase. In this work, we tested the model that the eukaryotic mismatch recognition complex tracks with the advancing ...
Joanna E Haye, Alison E Gammie
doaj   +1 more source