Results 21 to 30 of about 210,406 (304)

DNA Mismatch Repair [PDF]

EcoSal Plus, 2012
DNA mismatch repair (MMR) corrects replication errors in newly synthesized DNA. It also has an antirecombination action on heteroduplexes that contain similar but not identical sequences. This review focuses on the genetics and development of MMR and not on the latest biochemical mechanisms.
openaire   +2 more sources

The THE FREQUENCY OF MISMATCH REPAIR DEFICIENCY IN COLORECTAL CARCINOMA DETERMINED BY IMMUNOHISTOCHEMISTRY

Pakistan Armed Forces Medical Journal, 2021
Objective: To determine the frequency of mismatch repair deficiency in colorectal carcinoma determined by immunohistochemistry. Study Design: Cross-sectional study.
Maria Naseem, Muhammad Asif, Hafeez Ud Din, Muhammad Tahir Khadim, Ahmed Ahson Khan, Shahid Jamal, Iman Shoaib   +6 more
doaj   +1 more source

Endonuclease activities of MutLα and its homologs in DNA mismatch repair. [PDF]

, 2016
MutLα is a key component of the DNA mismatch repair system in eukaryotes. The DNA mismatch repair system has several genetic stabilization functions. Of these functions, DNA mismatch repair is the major one.
Kadyrov, Farid A, Kadyrova, Lyudmila Y
core   +2 more sources

Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair

eLife, 2018
Tumors defective for DNA polymerase (Pol) ε proofreading have the highest tumor mutation burden identified. A major unanswered question is whether loss of Pol ε proofreading by itself is sufficient to drive this mutagenesis, or whether additional factors
Karl P Hodel, Richard de Borja, Erin E Henninger, Brittany B Campbell, Nathan Ungerleider, Nicholas Light, Tong Wu, Kimberly G LeCompte, A Yasemin Goksenin, Bruce A Bunnell, Uri Tabori, Adam Shlien, Zachary F Pursell   +12 more
doaj   +1 more source

Conditional DNA repair mutants enable highly precise genome engineering [PDF]

, 2014
Oligonucleotide-mediated multiplex genome engineering is an important tool for bacterial genome editing. The efficient application of this technique requires the inactivation of the endogenous methyl-directed mismatch repair system that in turn leads to ...
Csorgő, Bálint, Latinovics, Dóra, Nagy, István, Nyerges, Ákos, Pál, Csaba, Pósfai, György, Szamecz, Béla   +6 more
core   +2 more sources

Escherichia coli frameshift mutation rate depends on the chromosomal context but not on the GATC content near the mutation site. [PDF]

PLoS ONE, 2012
Different studies have suggested that mutation rate varies at different positions in the genome. In this work we analyzed if the chromosomal context and/or the presence of GATC sites can affect the frameshift mutation rate in the Escherichia coli genome.
Mariana A Martina, Elisa M E Correa, Carlos E Argaraña, José L Barra   +3 more
doaj   +1 more source

A Strategy for Imidazotetrazine Prodrugs with Anti-cancer Activity Independent of MGMT and MMR [PDF]

, 2012
The imidazotetrazine ring is an acid-stable precursor and prodrug of highly-reactive alkyl diazonium ions. We have shown that this reactivity can be managed productively in an aqueous system for the generation of aziridinium ions with 96% efficiency. The
Garelnabi, EAE, Hartley, JA, Karodia, N, Kiakos, K, Li, L, Phillips, Roger, Pletsas, D, Wheelhouse, RT   +7 more
core   +1 more source

Signalling cell cycle arrest and cell death through the MMR System [PDF]

, 2006
Loss of DNA mismatch repair (MMR) in mammalian cells, as well as having a causative role in cancer, has been linked to resistance to certain DNA damaging agents including clinically important cytotoxic chemotherapeutics.
Brown, R., O'Brien, V.
core   +1 more source

Non-homologous end-joining pathway associated with occurrence of myocardial infarction: gene set analysis of genome-wide association study data [PDF]

, 2013
<p>Purpose: DNA repair deficiencies have been postulated to play a role in the development and progression of cardiovascular disease (CVD). The hypothesis is that DNA damage accumulating with age may induce cell death, which promotes formation of ...
A Choudhury, A Torkamani, AL Dixon, AP Bazo, B Arcidiacono, Bastiaan T. Heijmans, BJ Lamarche, Brendan M. Buckley, C Matthews, CD Ragnauth, Consortium Wellcome Trust Case Control, D Thorne, David J. Stott, E Durand, E Poch, F Gizard, G Bauriedel, G Macintyre, G Perez-Rivero, G Voghel, GJ Williams, GS Stewart, H Gui, H Schunkert, Henk-Jan Guchelaar, HY Shyu, Ian Ford, IS Ockene, J Shepherd, J Shepherd, J. Wouter Jukema, Jeanine J. Houwing-Duistermaat, Jeffrey J. W. Verschuren, Joris Deelen, JR Mercer, K Allen-Brady, K Wang, LS Waters, M Corral-Debrinski, M Durik, M Kanehisa, M Mahmoudi, M Satoh, MA Loizidou, MF Moffatt, MG Andreassi, MK Shimada, ML Rossi, ML Sampietro, Naveed Sattar, NJ Samani, OK Mirzoeva, P. Eline Slagboom, S Furukawa, S Knudsen, S Mahabir, S Ozturk, S Purcell, S Purcell, S Trompet, SC Liu, Sergey Korolev, Stella Trompet, T Minamino, T Zeller, V Borde, V Borde, WR Agema, X Xie, Y Li, YB Park   +70 more
core   +3 more sources

Blockade of LAG3 enhances responses of tumor-infiltrating T cells in mismatch repair-proficient liver metastases of colorectal cancer

OncoImmunology, 2018
Purpose: Liver metastasis develops in >50% of patients with colorectal cancer (CRC), and is a leading cause of CRC-related mortality. We aimed to identify which inhibitory immune checkpoint pathways can be targeted to enhance functionality of intra ...
Guoying Zhou, Lisanne Noordam, Dave Sprengers, Michail Doukas, Patrick P. C. Boor, Adriaan A. van Beek, Remco Erkens, Shanta Mancham, Dirk Grünhagen, Anand G. Menon, Johan F. Lange, Pim J. W. A. Burger, Alexandra Brandt, Boris Galjart, Cornelis Verhoef, Jaap Kwekkeboom, Marco J. Bruno   +16 more
doaj   +1 more source