Results 11 to 20 of about 811,508 (257)

Variation in the risk of colorectal cancer in families with Lynch syndrome: a retrospective cohort study.

, 2022
BACKGROUND: Existing clinical practice guidelines for carriers of pathogenic variants of DNA mismatch repair genes (Lynch syndrome) are based on the mean age-specific cumulative risk (penetrance) of colorectal cancer for all carriers of pathogenic ...
International Mismatch Repair Consortium,
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C-terminal fluorescent labeling impairs functionality of DNA mismatch repair proteins [PDF]

, 2012
The human DNA mismatch repair (MMR) process is crucial to maintain the integrity of the genome and requires many different proteins which interact perfectly and coordinated.
Hinrichsen, Inga Malena, Stefan Zeuzem, Hinrichsen Inga, Sandra Passmann, Plotz Guido, Adam, Ronja Sophia Mercedes, Plotz, Guido, Zeuzem Stefan, Guido Plotz, Passmann, Sandra, Angela Brieger, Ronja Adam, Brieger, Angela, Inga Hinrichsen, Brieger Angela, Passmann Sandra, Adam Ronja, Zeuzem, Stefan   +17 more
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Attaching and effacing Escherichia coli downregulate DNA mismatch repair protein in vitro and are associated with colorectal adenocarcinomas in humans [PDF]

, 2009
Background: Mucosa-associated Escherichia coli are frequently found in the colonic mucosa of patients with colorectal adenocarcinoma, but rarely in healthy controls. Chronic mucosal E. coli infection has therefore been linked to colonic tumourigenesis. E.
Short, Abigail J., Abigail J Short, Maddocks, Oliver D. K., Donnenberg, Michael S., Abigail J. Short, David J Harrison, Oliver D K Maddocks, Bader, Scott, Scott Bader, Michael S. Donnenberg, Michael S Donnenberg, Maddocks, Oliver D.K., Oliver D. K. Maddocks, David J. Harrison, Harrison, David J.   +14 more
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Functional Characterization of Excision Repair and RecA-Dependent Recombinational DNA Repair in Campylobacter jejuni [PDF]

, 2009
The presence and functionality of DNA repair mechanisms in Campylobacter jejuni are largely unknown. In silico analysis of the complete translated genome of C.
Dep Infectieziekten Immunologie, de Boer, A.G., Graaf-van Bloois, L., van der, Gaasbeek, E.J., Strategic Infection Biology, van Putten, J.P.M., van der Graaf-van Bloois, L., Boer, P., Wagenaar, J.A., Vermaning, B.J., van der Wal, F.J., Wal, F.J., van der, Putten, J.P.M., van, Boer, A.G., de   +13 more
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REPAIRtoire--a database of DNA repair pathways. [PDF]

, 2010
REPAIRtoire is the first comprehensive database resource for systems biology of DNA damage and repair. The database collects and organizes the following types of information: (i) DNA damage linked to environmental mutagenic and cytotoxic agents, (ii ...
Rother, Kristian, K. Poleszak, Papaj, Grzegorz, E. Osinska, Bujnicki, Janusz M, Lesiak, Justyna, G. Papaj, J. Lesiak, Milanowska, Kaja, J. Krwawicz, Kosinski, Jan, K. Rother, Krwawicz, Joanna, K. Milanowska, Poleszak, Katarzyna, Osinska, Ewelina, J. Kosinski, J. M. Bujnicki   +17 more
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Preprint: Mutation Rate Evolution Drives Immune Escape In Mismatch Repair-Deficient Cancer

, 2022
SUMMARY Mutation rate optimisation drives evolution and immune evasion of bacteria and lentiviral strains, including HIV. Whether evolving cancer lineages similarly adapt mutation rates to increase tumour cell fitness is unknown.
Daniel Hochhauser, Hamzeh Kayhanian, Panagiotis Barmpoutis, Luis Zapata, Trevor Graham, Andrea Sottoriva, Christopher Steele, Chen Jin, Manuel Rodriguez-Justo, Naomi Guppy, Eszter Lakatos, Daniel Alexander, Marjolijn J.L. Ligtenberg, Kevin Litchfield, Khurum Khan, Iris D. Nagtegaal, Nischalan Pillay, Genomics England Research Consortium, William Waddingham, Giulio Caravagna, Marco Novelli, Kai-Keen Shiu, William Cross, Benjamin Werner, Christopher Ross, Salvatore Milite, Marnix Jansen, Dominic Patel, Ann-Marie Baker, Josep Linares   +29 more
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Synthesis and quantitative structure-activity relationship of imidazotetrazine prodrugs with activity independent of O6-methylguanine-DNA-methyltransferase, DNA mismatch repair, and p53 [PDF]

, 2013
YesThe antitumor prodrug temozolomide is compromised by its dependence for activity on DNA mismatch repair (MMR) and the repair of the chemosensitive DNA lesion, O6-methylguanine (O6-MeG), by O6-methylguanine-DNA-methyltransferase (E.C.
Phillips, Roger M., Wheelhouse, Richard T., Li, Li, Pletsas, D, Garelnabi, EAE, Li, L, Phillips, Roger, Garelnabi, Elrashied A.E., Wheelhouse, RT, Pletsas, Dimitrios   +9 more
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Proofreading deficiency of Pol I increases the levels of spontaneous rpoB mutations in E. coli [PDF]

, 2011
The fidelity role of DNA polymerase I in chromosomal DNA replication in E. coli was investigated using the rpoB forward target. These experiments indicated that in a strain carrying a proofreading-exonuclease-defective form of Pol I (polAexo mutant) the ...
Jonczyk, Piotr, K. Makiela-Dzbenska, P. Jonczyk, Fijalkowska, Iwona J., Schaaper, Roel, R.M. Schaaper, I.J. Fijalkowska, Makiela-Dzbenska, Karolina   +7 more
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The THE FREQUENCY OF MISMATCH REPAIR DEFICIENCY IN COLORECTAL CARCINOMA DETERMINED BY IMMUNOHISTOCHEMISTRY

Pakistan Armed Forces Medical Journal, 2021
Objective: To determine the frequency of mismatch repair deficiency in colorectal carcinoma determined by immunohistochemistry. Study Design: Cross-sectional study.
Maria Naseem, Muhammad Asif, Hafeez Ud Din, Muhammad Tahir Khadim, Ahmed Ahson Khan, Shahid Jamal, Iman Shoaib   +6 more
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N‐terminus of hMLH1 confers interaction of hMutLα and hMutLβ with hMutSα [PDF]

, 2006
Mismatch repair is a highly conserved system that ensures replication fidelity by repairing mispairs after DNA synthesis. In humans, the two protein heterodimers hMutSα (hMSH2‐hMSH6) and hMutLα (hMLH1‐hPMS2) constitute the centre of the repair reaction ...
Trojan, Jörg, Brieger, Angela, Raedle, Jochen, Plotz, Guido, Zeuzem, Stefan   +4 more
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