Results 11 to 20 of about 97,151 (260)
Postreplicative Mismatch Repair [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 The mismatch repair (MMR) system detects non-Watson-Crick base pairs and strand misalignments arising during DNA replication and mediates their removal by catalyzing excision of the mispair-containing tract of nascent DNA and its error-free resynthesis. In this way, MMR improves the fidelity of replication by several orders of magnitude.
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An Msh3 ATPase domain mutation has no effect on MMR function
BMC Research Notes, 2017 Objective To demonstrate that the Msh3 ATPase domain is required for DNA mismatch repair and tumor suppression in a murine model. Results The DNA mismatch repair proteins are members of the ABC family of ATPases.
Yasmin Edwards
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An end for mismatch repair [PDF]
Proceedings of the National Academy of Sciences, 2010 DNA mismatch repair (MMR) is an important postreplicative repair mechanism that removes DNA polymerization errors and is responsible for increasing the fidelity of genome replication by orders of magnitude. Defects in MMR lead to the most common form of hereditary colon cancer and a variety of sporadic cancers (1–3).
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EcoSal Plus, 2012 DNA mismatch repair (MMR) corrects replication errors in newly synthesized DNA. It also has an antirecombination action on heteroduplexes that contain similar but not identical sequences. This review focuses on the genetics and development of MMR and not on the latest biochemical mechanisms.
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eLife, 2018 Tumors defective for DNA polymerase (Pol) ε proofreading have the highest tumor mutation burden identified. A major unanswered question is whether loss of Pol ε proofreading by itself is sufficient to drive this mutagenesis, or whether additional factors
Karl P Hodel +12 more
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Pakistan Armed Forces Medical Journal, 2021 Objective: To determine the frequency of mismatch repair deficiency in colorectal carcinoma determined by immunohistochemistry. Study Design: Cross-sectional study.
Maria Naseem +6 more
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Escherichia coli frameshift mutation rate depends on the chromosomal context but not on the GATC content near the mutation site. [PDF]
PLoS ONE, 2012 Different studies have suggested that mutation rate varies at different positions in the genome. In this work we analyzed if the chromosomal context and/or the presence of GATC sites can affect the frameshift mutation rate in the Escherichia coli genome.
Mariana A Martina +3 more
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DNA mismatch repair and infertility [PDF]
Current Opinion in Urology, 2010 To highlight the significance of the abnormal DNA repair mechanism in male infertility.DNA repair defects cause a variety of spermatogenic defects in mouse models. Evidence is accumulating to demonstrate the importance of DNA repair defects in human nonobstructive azoospermia.
Sarmistha, Mukherjee +2 more
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Role of mismatch repair in aging [PDF]
International Journal of Biological Sciences, 2021 A common feature of aging is the accumulation of genetic damage throughout life. DNA damage can lead to genomic instability. Many diseases associated with premature aging are a result of increased accumulation of DNA damage. In order to minimize these damages, organisms have evolved a complex network of DNA repair mechanisms, including mismatch repair (
Wen, Jie +7 more
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OncoImmunology, 2018 Purpose: Liver metastasis develops in >50% of patients with colorectal cancer (CRC), and is a leading cause of CRC-related mortality. We aimed to identify which inhibitory immune checkpoint pathways can be targeted to enhance functionality of intra ...
Guoying Zhou +16 more
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