Results 201 to 210 of about 29,309 (251)

Discovery and Engineering of a Rat Endogenous Retrovirus Reverse Transcriptase for Efficient Prime Editing

Advanced Science, EarlyView.
We screened 558 reverse transcriptases and engineered an optimized rat endogenous retrovirus‐derived variant, enRERV‐RT, via structure‐guided engineering and deep mutational scanning. This enhanced prime editor, based on the engineered RT, outperforms conventional M‐MLV‐RT systems across plant and animal cells, particularly at hard‐to‐edit loci ...
Linsha Ma, Pengcheng Yao, Shengqi Wu, Yuanyuan Shi, Lang Qin, Baitao Li, Jiayi Zhu, Minhua Huang, Yichong Zhu, Yuwen Song, Jinhuan Pang, Ziping Guo, Guochuan Wu, Chen Wang, Kewei Xu, Ruihua Huang, Quan Kuang, Liang Qu, Changtian Pan, Xianrong Xie, Qinlong Zhu, Jiaying Huang, Qiupeng Lin   +22 more
wiley   +1 more source

Automated Extraction of Multicomponent Alloy Data Using Large Language Models for Sustainable Design

Advanced Science, EarlyView.
A large language model (LLM) based pipeline is developed to automatically extract a comprehensive and accurate multicomponent alloy database from literature corpus. The extracted dataset is integrated with sustainability indicators to identify potential alloys that outperform existing industrial benchmark materials in terms of both performance and ...
Aravindan Kamatchi Sundaram, Mohit Chakraborty, Sai Mani Kumar Devathi, B. Pabitramohan Prusty, Rohit Batra   +4 more
wiley   +1 more source

Correction for Hao et al., Synthetical lethality of Werner helicase and mismatch repair deficiency is mediated by p53 and PUMA in colon cancer. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

Radiomic model for preoperative prediction of mismatch repair deficiency in gastric cancer: a multicenter study integrating tumor sub-region radiomics and transcriptomics. [PDF]

Cancer Biol Med
Pan S, Li E, Zheng G, You Y, Zhang Y, Cao M, Zhang R, Yang Q, Wei Y, Zhu W, Shen K, Huang C, Xu J, Wang L, Ye Z, Xu Z, Hu C.   +16 more
europepmc   +1 more source

Entropy Decoding the Fundamental Law of Phase Competition in Glass Formation

Advanced Science, EarlyView.
We validate the integration of intermetallic and eutectic phases as initial phases for composition design. The phase competition mechanism in glass formation is quantitatively clarified based on the melting entropy of competing phases. Glass‐forming ability is modulated by tuning phase competition via the melting entropy of initial phases.
Benke Huo, Zhengqing Cai, Bingtao Wang, Zhenqiang Song, Shi‐Dong Feng, Zijing Li, Xingjun Liu, Li‐Min Wang   +7 more
wiley   +1 more source

Stress Accumulation Induced by Ion Exchange for Synchronous Modulation of Mode and Wavelength in Microlasers

Advanced Science, EarlyView.
This work demonstrates a paradigm‐shifting strategy to simultaneously achieve broadband wavelength tunability and single‐mode control within a single perovskite microwire structure. Using a facile heating‐assisted solid–solid anion‐exchange strategy, we synthesized phase‐pure CsPbClxBr3‐x microwires that exhibit the widest reported continuous lasing ...
Bingwang Yang, Lingling Sun, Jinhui Wang, Jitao Li, Peng Wan, Daning Shi, Caixia Kan, Mingming Jiang   +7 more
wiley   +1 more source

MMRNet: Ensemble deep learning models for predicting mismatch repair deficiency in endometrial cancer from histopathological images. [PDF]

Cell Rep Med
Liu LL, Jing BZ, Liu X, Li RG, Wan Z, Zhang JY, Ouyang XM, Kong QN, Kang XL, Wang DD, Chen HH, Zhao ZH, Liang HY, Huang MY, Zheng CY, Yang X, Zheng XY, Zhang XK, Wei LJ, Cao C, Gao HY, Luo RZ, Cai MY.   +22 more
europepmc   +1 more source

PRMT5 Inhibitor Synergizes with Chemotherapy to Induce Resembling Mismatch Repair Deficiency and Enhance Anti-TIGIT Therapy in Microsatellite-Stable Colorectal Cancer. [PDF]

Adv Sci (Weinh)
Zhu J, Fu S, Zou X, Zeng H, Cui G, Peng Y, Tang D, Zhang F, Shen H, Zeng S, Han Y.   +10 more
europepmc   +1 more source

Constitutional mismatch repair deficiency: a case on a commonly misinterpreted mutation in colon cancer. [PDF]

Clin J Gastroenterol
C K, H E, E T, M A, A C, A P, J S.
europepmc   +1 more source

Case Report: Metastatic small bowel adenocarcinoma with DNA mismatch repair deficiency in an organ transplant recipient treated with anti-PD-1 immunotherapy. [PDF]

Front Oncol
Phung QH, Tsai AK, Park BU, Schat R, Spong R, Tsai LJ, Kulkarni AA, Antonarakis ES, Gupta A.   +8 more
europepmc   +1 more source