Results 221 to 230 of about 29,309 (251)
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DNA Mismatch Repair Deficiency in Endometrial Carcinoma
International Journal of Gynecological Pathology, 2009Microsatellite instability (MSI) is the hallmark of a molecular pathway to carcinogenesis due to sporadic or inherited abnormalities of DNA mismatch repair genes. Inherited mutations are seen in hereditary nonpolyposis colorectal cancer syndrome. Endometrial carcinoma shows as high an incidence of MSI as does colorectal carcinoma.
Yevgeniy, Karamurzin +1 more
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Therapeutic targeting of mismatch repair-deficient cancers
Nature Reviews Clinical OncologyDNA mismatch repair (MMR) is one of many evolutionarily conserved processes that act as guardians of genomic integrity. MMR proteins recognize errors that occur during DNA replication and initiate countermeasures to rectify those mistakes. MMR deficiency (MMRd) therefore leads to a dramatic accumulation of mutations.
Paul Johannet +4 more
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Autoamputation in Mismatch Repair–Deficient Colon Cancer
JAMA OncologyA woman in her 50s with a history of hemochromatosis, psoriasis, and type 2 diabetes presented with a 3-month history of abdominal pain, weight loss, and a large palpable fixed abdominal mass. What is your diagnosis?
Michael, Flanagan +2 more
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DNA mismatch repair deficiency in conjunctival melanoma
Eye, 2023Aurora Rodriguez +2 more
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Prevalence of Mismatch-Repair Deficiency in Rectal Adenocarcinomas
New England Journal of Medicine, 2022David J. Papke +5 more
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Deficient DNA Mismatch Repair in Carcinogenesis
2003The postreplicative DNA mismatch repair (MMR) system maintains genome integrity by recognizing and repairing mismatched nucleotides that result from misincorporation during DNA synthesis. The genes coding for MMR proteins are highly conserved throughout evolution.
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Harnessing mismatch repair deficiency for therapeutic targeting in cancers
Expert Opinion on Therapeutic TargetsMismatch-repair deficiency (MMRd) is a pan-cancer mechanism resulting in high tumor mutation and microsatellite burden, leading to remarkable therapeutic success using immune checkpoint inhibition (ICI). However, efficacy remains variable. Our goal is to review the existing and emerging literature that provide mechanistic insights on how MMRd diversely
Irem, Yenidogan +2 more
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Prognostic and Predictive Values of Mismatch Repair Deficiency in Non-Metastatic Colorectal Cancer
Cancers, 2021Zhaohui Jin +2 more
exaly
Upregulation of TIGIT and PD-1 in Colorectal Cancer with Mismatch-repair Deficiency
Immunological Investigations, 2021Xiao-Liang Xie +2 more
exaly
Mismatch repair deficiency: The what, how and why it is important
Genes Chromosomes and Cancer, 2022Rondell Graham
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