Results 31 to 40 of about 1,149,362 (252)

Research Progress on Combined Immunotherapy for Microsatellite Stable Colorectal Cancer

Zhongliu Fangzhi Yanjiu, 2022
In recent years, immunotherapy has achieved great progress in the treatment of malignant tumors and has enriched the treatment mode of many types of malignant tumors. Colorectal cancer is a common tumor worldwide.
YIN Zhucheng, LIANG Xinjun
doaj   +1 more source

Curcumin Chemosensitizes 5-Fluorouracil Resistant MMR-Deficient Human Colon Cancer Cells in High Density Cultures [PDF]

, 2014
Objective Treatment of colorectal cancer (CRC) remains a clinical challenge, as more than 15% of patients are resistant to 5-Fluorouracil (5-FU)-based chemotherapeutic regimens, and tumor recurrence rates can be as high as 50–60%.
Patricia Kraehe, Kraehe Patricia, Shayan, Parviz, Lueders, Cora, Shayan Parviz, Lueders Cora, Shakibaei Mehdi, Mehdi Shakibaei, Parviz Shayan, Goel Ajay, Buhrmann Constanze, Ajay Goel, Cora Lueders, Shakibaei, Mehdi, Constanze Buhrmann, Buhrmann, Constanze, Goel, Ajay, Kraehe, Patricia   +17 more
core   +1 more source

Mismatch Repair Deficiency as a Predictive Biomarker for Immunotherapy Efficacy [PDF]

, 2017
Immunotherapy has revolutionized cancer treatment. Immune-checkpoint inhibitors, on balance, showed a favorable efficacy/toxicity profile with durable response in different cancer types.
G. Curigliano, G. Viale, D. Trapani
core   +3 more sources

N‐terminus of hMLH1 confers interaction of hMutLα and hMutLβ with hMutSα [PDF]

, 2006
Mismatch repair is a highly conserved system that ensures replication fidelity by repairing mispairs after DNA synthesis. In humans, the two protein heterodimers hMutSα (hMSH2‐hMSH6) and hMutLα (hMLH1‐hPMS2) constitute the centre of the repair reaction ...
Trojan, Jörg, Brieger, Angela, Raedle, Jochen, Plotz, Guido, Zeuzem, Stefan   +4 more
core   +1 more source

Histopathologic Features for Overall Survival in Merkel Cell Carcinoma: A Case Series with Intact Mismatch Repair Protein Expression

Türk Patoloji Dergisi, 2023
Objective: In a study of Merkel cell carcinoma (MCC), a fusion transcript between MLH1 and SPATA4 was identified. This fusion has the potential to generate the inactive or dominant-negative form of the protein.
Selin KESTEL, Betul OGUT, Mehmet Arda INAN, Ozlem ERDEM   +3 more
doaj   +1 more source

Presentation of Acute Lymphoblastic Lymphoma and Colorectal Carcinoma in the Context of Constitutional Mismatch Repair Deficiency Syndrome (CMMRD): a Case Report with Literature Review

Journal of Cancer and Allied Specialties, 2021
Introduction: Constitutional mismatch repair deficiency (CMMRD) is a rare autosomal recessive disease-carrying an increased risk of cancers (pediatric tumors of central nervous system, haemato-lymphoid malignancies along with gastrointestinal (GI) cancer(
Muhammad Irfan Basheer, Iftikhar Ali Rana, Umer Nisar Sheikh, Muhammad Aasim Yusuf, Irfana Ishaq Sindhu, Asif Loya   +5 more
doaj   +1 more source

Pms2 suppresses large expansions of the (GAA·TTC)n sequence in neuronal tissues [PDF]

, 2012
Copyright @ 2012 Bourn et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
De Biase, I, Al-Mahdawi, S, De Biase Irene, Al-Mahdawi Sahar, Pinto Ricardo Mouro, Sandi, C, Pook, MA, Pinto, RM, Sahar Al-Mahdawi, Chiranjeevi Sandi, Sandi Chiranjeevi, Sanjay I Bidichandani, Bourn Rebecka L., Bidichandani, S, Irene De Biase, Bourn, RL, Ricardo Mouro Pinto, Pook Mark A., Rebecka L Bourn, Bidichandani Sanjay I., Mark A Pook   +20 more
core   +2 more sources

Cerebral developmental venous anomalies in children with mismatch repair deficiency

The Turkish Journal of Pediatrics, 2022
Background. Constitutional mismatch repair deficiency (CMMRD) is one of the rare cancer predisposition syndromes. The aim of this study was to evaluate the cerebral developmental venous anomalies in children with central nervous system tumors ...
Buket Kara, Yahya Paksoy, Ahmet Okay Çağlayan, Nusret Seher, Hilal Akbaş, Yavuz Köksal   +5 more
doaj   +1 more source

Eukaryotic DNA Mismatch Repair In Vitro

, 2012
Mismatch repair corrects biosynthetic errors generated during DNA replication. Mismatch repair deficiency causes a mutator phenotype and directly underlies hereditary nonpolyposis colorectal cancer and some sporadic cancers.
Yuan, Fenghua, Liu, Fengsong, Gu, Liya, Song, Limin, Fengsong Liu, Liya Gu, Fenghua Yuan, Yanbin Zhang, Limin Song, Zhang, Yanbin   +9 more
core   +1 more source

Long-term benefit of immunotherapy in a patient with squamous lung cancer exhibiting mismatch repair deficient/high microsatellite instability/high tumor mutational burden: A case report and literature review

Frontiers in Immunology, 2023
Genetic mutations that render mismatch repair defective may result in microsatellite instability, which is common in colorectal carcinomas and gastric cancers as well as Lynch syndrome. Mismatch repair deficiency/high microsatellite instability (dMMR/MSI-
Na Li, Zixuan Wan, Dongyan Lu, Ruilian Chen, Xiaowei Ye   +4 more
doaj   +1 more source