Results 21 to 30 of about 1,149,362 (252)

Assessment of mismatch repair deficiency in ovarian cancer

, 2021
BACKGROUND: Hereditary causes of ovarian cancer include Lynch syndrome, which is due to inherited pathogenic variants affecting one of the four mismatch repair genes involved in DNA repair.
Crosbie, Emma J, McVey, Rhona J, Lalloo, Fiona, Clancy, Tara, Crosbie, Emma; id_orcid, Evans, D Gareth, Woodward, Emma R, Bolton, James, McVey, Rhona J., Wallace, Andrew J, Ryan, Neil A J, Bowers, Naomi, Evans, D Gareth; id_orcid, McMahon, Raymond F, Wallace, Andrew J., Ryan, Neil, McMahon, Ray, Woodward, Emma; id_orcid, Green, Kate   +18 more
core   +1 more source

Association of clinicopathological features with DNA mismatch repair status among colorectal cancer patients presenting to a Tertiary Care Cancer Hospital

International Journal of Advanced Medical and Health Research, 2022
Background: About 12%–15% of sporadic colorectal cancers (CRCs) display a defect in the DNA mismatch repair (MMR) system resulting in microsatellite instability (MSI).
Gayathri G Nair, Vijayalakshmi Nair, Usha Mary Abraham   +2 more
doaj   +1 more source

Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair

eLife, 2018
Tumors defective for DNA polymerase (Pol) ε proofreading have the highest tumor mutation burden identified. A major unanswered question is whether loss of Pol ε proofreading by itself is sufficient to drive this mutagenesis, or whether additional factors
Karl P Hodel, Richard de Borja, Erin E Henninger, Brittany B Campbell, Nathan Ungerleider, Nicholas Light, Tong Wu, Kimberly G LeCompte, A Yasemin Goksenin, Bruce A Bunnell, Uri Tabori, Adam Shlien, Zachary F Pursell   +12 more
doaj   +1 more source

Functional Characterization of Excision Repair and RecA-Dependent Recombinational DNA Repair in Campylobacter jejuni [PDF]

, 2009
The presence and functionality of DNA repair mechanisms in Campylobacter jejuni are largely unknown. In silico analysis of the complete translated genome of C.
Dep Infectieziekten Immunologie, de Boer, A.G., Graaf-van Bloois, L., van der, Gaasbeek, E.J., Strategic Infection Biology, van Putten, J.P.M., van der Graaf-van Bloois, L., Boer, P., Wagenaar, J.A., Vermaning, B.J., van der Wal, F.J., Wal, F.J., van der, Putten, J.P.M., van, Boer, A.G., de   +13 more
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A human cancer-associated truncation of MBD4 causes dominant negative impairment of DNA repair in colon cancer cells [PDF]

, 2007
MBD4 binds to methylated DNA and acts as a thymine DNA glycosylase in base excision repair. Deficiency of MBD4 in mice enhances mutation at CpG sites and alters apoptosis in response to DNA damage, but does not increase tumorigenesis in mismatch repair ...
Bader, S A, S A Bader, D J Harrison, M Walker, Harrison, D J, Walker, M   +5 more
core   +1 more source

REPAIRtoire--a database of DNA repair pathways. [PDF]

, 2010
REPAIRtoire is the first comprehensive database resource for systems biology of DNA damage and repair. The database collects and organizes the following types of information: (i) DNA damage linked to environmental mutagenic and cytotoxic agents, (ii ...
Rother, Kristian, K. Poleszak, Papaj, Grzegorz, E. Osinska, Bujnicki, Janusz M, Lesiak, Justyna, G. Papaj, J. Lesiak, Milanowska, Kaja, J. Krwawicz, Kosinski, Jan, K. Rother, Krwawicz, Joanna, K. Milanowska, Poleszak, Katarzyna, Osinska, Ewelina, J. Kosinski, J. M. Bujnicki   +17 more
core   +1 more source

Mismatch repair deficiency as prognostic factor for stage III small bowel adenocarcinoma: A multicentric international study

, 2023
Background: Small bowel adenocarcinoma (SBA) is a rare cancer with an aggressive behavior. No study has specifically addressed the putative prognostic role of mismatch repair status in stage III SBAs. Aims: We aimed to investigate whether mismatch repair
Ferrante M., Fassan M., Camilla, Guerini, Andrea, Casadei Gardini, Gert, De Hertogh, Paulli M., Lenti M. V., Vanoli A., Sessa F., Furlan D., Maria Cristina, Macciomei, Giovanni, Arpa, Marco Vincenzo, Lenti, Alessandro, Vanoli, Fausto, Sessa, Rondell Patrell, Graham, Klersy C., Stefano, Cascinu, Macciomei M. C., Matteo, Fassan, Grillo F., Catherine, Klersy, De Hertogh G., Graham R. P., Marco, Paulli, Antonio, Di Sabatino, Erica, Quaquarini, Guerini C., Moens A., Neri G., Marc, Ferrante, Giuseppe, Neri, Casadei Gardini A., Arpa G., Annick, Moens, Quaquarini E., Di Sabatino A., Daniela, Furlan, Federica, Grillo, Cascinu S.   +39 more
core   +2 more sources

Mismatch repair deficiency in early‐onset duodenal, ampullary, and pancreatic carcinomas is a strong indicator for a hereditary defect

The Journal of Pathology: Clinical Research, 2022
Mismatch repair deficiency (dMMR) is a hallmark of Lynch syndrome (LS), but its prevalence in early‐onset (diagnosed under the age of 50 years) duodenal, ampullary, and pancreatic carcinomas (DC, AC, and PC, respectively) is largely unknown.
Valentyna Kryklyva, Lodewijk AA Brosens, Monica AJ Marijnissen‐van Zanten, Marjolijn JL Ligtenberg, Iris D Nagtegaal   +4 more
doaj   +1 more source

Synthesis and quantitative structure-activity relationship of imidazotetrazine prodrugs with activity independent of O6-methylguanine-DNA-methyltransferase, DNA mismatch repair, and p53 [PDF]

, 2013
YesThe antitumor prodrug temozolomide is compromised by its dependence for activity on DNA mismatch repair (MMR) and the repair of the chemosensitive DNA lesion, O6-methylguanine (O6-MeG), by O6-methylguanine-DNA-methyltransferase (E.C.
Phillips, Roger M., Wheelhouse, Richard T., Li, Li, Pletsas, D, Garelnabi, EAE, Li, L, Phillips, Roger, Garelnabi, Elrashied A.E., Wheelhouse, RT, Pletsas, Dimitrios   +9 more
core   +1 more source

PPARδ status and mismatch repair mediated neoplasia in the mouse intestine

BMC Cancer, 2006
Background Therapeutic regulation of PPARδ activity using selective agonists has been proposed for various disorders. However, the consequences of altered peroxisome proliferator-activated receptor delta (PPARδ) activity in the context of intestinal ...
Peters Jeffrey M, Gescher Andreas J, Hayes Anthony J, Sansom Owen J, Reed Karen R, Clarke Alan R   +5 more
doaj   +1 more source