The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
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Wozu Strafrecht? Another View of the Cathedral [PDF]
Der Beitrag befaßt sich mit der Frage, inwieweit dem Strafrecht ein Eigengewicht im staatlichen Sanktionensystem zukommt. Im Kern geht es dabei um die wechselseitige Beziehung zwischen Strafrecht und Zivilrecht, die paradigmatisch durch die Stichworte ...
Schmidtchen, Dieter
core
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
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Journal of EngineeringThis paper presents an optimal design and simulation of a novel enhanced model reference adaptive proportional–integral–derivative controller (MRAPIDC) for underactuated nonlinear systems with parametric uncertainty.
Ahmed Abduljabbar Mahmood +1 more
doaj +1 more source
Machine Learning with ApplicationsPattern detection is one of the essential technologies in computer vision. To solve pattern detection problems, the system needs a vast amount of computational resources.
Hiroshi Kage
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Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Sentence Comprehension: The Integration of Habits and Rules David J. Townsend and Thomas G. Bever (Montclair State University and University of Arizona) Cambridge, MA: MIT Press (Language, speech, and communication series), 2001, xi+445 pp; hardbound, ISBN 0-262-20132-1, $65.00, £44.95; paperbound, ISBN 0-262-70080-8, $24.95, £16.00 [PDF]
, 2002 Matthew W. Crocker
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Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
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