Results 121 to 130 of about 702,334 (288)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Die "Canadian Head Rule" für Patienten mit leichtem Schädelhirntrauma
, 2004 Hintergrund: Sensitivität, Spezifität und Anwendbarkeit der Canadian Head Rule (CHR) wurde für Münsteraner Patienten evaluiert. Methoden: Eingeschlossen wurden 122 SHT-Patienten (m=74; w=48; 40.0 +/- 19.0J) der Jahre 1999-2000. Die Indikation zur CCT wurde entsprechend der CHR ermittelt und mit den CCT-Resultaten verglichen. Ergebnisse: 4/122 Patienten
openaire
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Journal of EngineeringThis paper presents an optimal design and simulation of a novel enhanced model reference adaptive proportional–integral–derivative controller (MRAPIDC) for underactuated nonlinear systems with parametric uncertainty.
Ahmed Abduljabbar Mahmood +1 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Machine Learning with ApplicationsPattern detection is one of the essential technologies in computer vision. To solve pattern detection problems, the system needs a vast amount of computational resources.
Hiroshi Kage
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Advanced pH neutralization control using model reference adaptive control (MRAC) with MIT rule
Chemical Industry and Chemical Engineering QuarterlyThis study presents the design and implementation of a Model Reference AdaptiveController (MRAC) using the MIT rule for a pH neutralization process in a continuous reactor.The inherent nonlinearity of acid-base reactions makes conventional PID control insufficient inhandling rapid pH variations.
openaire +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source