Results 181 to 190 of about 28,640 (298)

Early detection of central line-associated bloodstream infection in intensive care unit patients using the systemic inflammatory response index (SIRI). [PDF]

GMS Hyg Infect Control
Lahariya R, Anand G.
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

The Case for a Countercyclical Rule-based Fiscal Regime [PDF]

We build a general equilibrium model of a small open economy, with the purpose of analyzing the effects of a countercyclical rule-based fiscal regime, which corresponds to a stylized version of the structural balance in place in Chile.
Jorge Restrepo, Carlos Garcia
core  

Forschung mit Folgen / Rules of Research – [Rezension]

, 2012
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Local Rule Switching Mechanism for Viral Shell Geometry

, 1995
In a previous paper [Berger et al., PNAS 91 7732,1994] a theory of virus shell formation was proposed in which shell assembly is directed by local interactions of the coat ans scaffolding subunits.
Shor, Peter W., Berger, Bonnie
core  

Development of a semi-real-time electrocardiogram monitoring system integrating artificial intelligence and wearable devices for atrial fibrillation screening. [PDF]

Digit Health
Van Nguyen S, Khac Ho M, Vu Nguyen D, Quang Nguyen C, Le Pham A, Thanh Quach H.   +5 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Monetary Policy under Rule-of-Thumb Consumers and External Habits [PDF]

This paper develops and estimates a simple New Keynesian Dynamic Stochastic General Equilibrium (DSGE) model with rule-of-thumb consumers and external habits.
Massimiliano Tancioni, Giovanni Di Bartolomeo, Lorenza Rossi   +2 more
core  

Secure Multi-Directional Independent Transmission Based on Directional Modulated 2D Conformal Phased Array. [PDF]

Sensors (Basel)
Wu F, Zhang P, Qin Y, Gong X, Lu H.
europepmc   +1 more source