Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Long Short-Term Memory-GPT-4 Integration for Interpretable Biomedical Signal Classification: Proof-of-Concept Study. [PDF]
JMIR Form ResPoreddy KKR +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Heart disease diagnosis and categorization from ECG signals using hybrid Fuzzy-CNN machine optimized by meta-heuristic algorithms. [PDF]
Sci RepDavani M +3 more
europepmc +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Classification of multi-lead ECG based on multiple scales and hierarchical feature convolutional neural networks. [PDF]
Sci RepZhou F, Fang D.
europepmc +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Autocratic rule in ethnically-diverse societies
Richer and more educated citizens demand better governance than poorer citizens. They participate more in the political process, are more difficult to buy off, and tend to have the financial resources to support a revolt.
Amegashie, J. Atsu
core
Towards Interpretable Seizure Detection: An Excitation/Inhibition Dynamic Polynomial Network Framework for Electroencephalography. [PDF]
Sensors (Basel)Sun X +7 more
europepmc +1 more source
, 2017 Model Reference Adaptive Control (MRAC) strategies find application in flight control because of changes in dynamics of flight conditions. This paper demonstrates an application of Fractional Order Adjustment Rule MRAC (FOAR-MRAC) with the modification of model error dead zone for adaptive control of Twin Rotor Multi-input multi-output System (TRMS ...
Kavuran, Gurkan +3 more
openaire +1 more source