Accounting for the nuclear and mito genome in dairy cattle breeding—A simulation study [PDF]
JDS CommunicationsMitochondria play a significant role in numerous cellular processes through proteins encoded by both the nuclear genome (nDNA) and mito genome (mDNA), and increasing evidence shows that traits of interest might be affected by mito-nuclear interactions ...
Gabriela Mafra Fortuna +4 more
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Accounting for nuclear- and mito-genome in genetic evaluation and breeding of dairy cattle [PDF]
, 2022 Studies indicate that mito-genome variation impacts phenotypes in a range of species. In dairy cattle up to 5% of phenotypic variation for milk production has been associated to mito-genome variation. Bearing in mind that milk production is a very energy demanding process that inflicts systemic physiological changes, it is logical to expect that it ...
Mafra Fortuna, Gabriela +4 more
core +5 more sources
Gatekeepers of the Germ Line: How Mitochondria Shape Reproductive Evolution in Metazoans [PDF]
BiologyMitochondria play essential roles for animal reproduction, influencing not only cellular energetics but also gamete quality, inheritance and evolutionary patterns.
Yu-Tong Sun, Wan-Xi Yang
doaj +2 more sources
, 2023 AbstractMitochondria play a significant role in numerous cellular processes through proteins encoded by both nuclear genome (nDNA) and mito genome (mDNA). While the variation in nDNA is influenced by mutations and recombination of parental genomes, the variation in mDNA is solely driven by mutations.
Gabriela Mafra Fortuna +4 more
openaire +4 more sources
COMPARATIVE MITO-GENOMIC ANALYSIS OF DIFFERENT SPECIES OF GENUS CANIS BY USING DIFFERENT BIOINFORMATICS TOOLS [PDF]
Journal of Bioresource Management, 2019 In the current study, the mitochondrial genes sequence for COI, Cyt b and 16s rRNA of seven species found in different parts of the world were retrieved from NCBI Gene Bank while, PCR products of COI, Cyt b and 16s rRNA genes obtained from C. lupus and C.aureus present in Pakistan were sequenced and aligned for comparison.
Rumman, Ume +4 more
openaire +4 more sources
Lipid nanoparticle delivery of the CRISPR/Cas9 system directly into the mitochondria of cells carrying m.7778G>T mutation in MtDNA (mt-Atp8) [PDF]
Scientific ReportsMitochondrial genome mutations are associated with various diseases and gene therapy targeted to mitochondria has the potential to effectively treat such diseases.
Kaede Norota +8 more
doaj +2 more sources
Accounting for nuclear and mito genome in dairy cattle breeding - a simulation study [PDF]
Mitochondria play a significant role in numerous cellular processes through proteins encoded by both the nuclear genome (nDNA) and mito genome (mDNA), and increasing evidence shows that traits of interest might be affected by mito-nuclear interactions.
Johnsson, Martin
openaire +3 more sources
PLoS ONE, 2022 The complete mitochondrial genome of Episymploce splendens, 15,802 bp in length, was determined and annotated in this study. The mito-genome included 13 PCGs, 20 tRNAs and 2 rRNAs.
Lin Yan +8 more
doaj +2 more sources
Direct evidence of CRISPR-Cas9-mediated mitochondrial genome editing
The Innovation, 2022 Pathogenic mitochondrial DNA (mtDNA) mutations can cause a variety of human diseases. The recent development of genome-editing technologies to manipulate mtDNA, such as mitochondria-targeted DNA nucleases and base editors, offer a promising way for ...
Rui Bi +12 more
doaj +1 more source
Evolved genetic and phenotypic differences due to mitochondrial-nuclear interactions. [PDF]
PLoS Genetics, 2017 The oxidative phosphorylation (OxPhos) pathway is responsible for most aerobic ATP production and is the only pathway with both nuclear and mitochondrial encoded proteins. The importance of the interactions between these two genomes has recently received
Tara Z Baris +7 more
doaj +1 more source